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Triple Agonist Design :

GLP-1 receptor: Retatrutide delays gastric emptying, suppress appetite, and promote secretion.

GIP receptor: Retatrutide enhances sensitivity and regulate central satiety signals.

Glucagon receptor (GCGR): Retatrutide activates liver energy metabolism, promote lipolysis and glycogenolysis, and increase basal metabolic rate.

The triple synergistic effect increases energy consumption while reducing energy intake, significantly improving weight loss effects.

Mechanism of Action and Molecular Structure of Retatrutide:

1)Triple Agonist Design
- GLP-1 receptor: Retatrutide delays gastric emptying, suppress appetite, and promote secretion.
- GIP receptor: Retatrutide enhances insulin sensitivity and regulate central satiety signals.
- Glucagon receptor (GCGR): Retatrutide activates liver energy metabolism, promote lipolysis and glycogenolysis, and increase basal metabolic rate.
The triple synergistic effect increases energy consumption while reducing energy intake, significantly improving weight loss effects.

2) Structural Optimization
- Based on the GIP skeleton modification, non-natural amino acids (such as α-methylleucine at position 13) are introduced to enhance receptor affinity.
- The half-life is extended to 7 days through fatty acid side chain modification