Quality Forged, Efficacy Inherited | Trustworthy TB500 for Global Health Innovation
1 Inquiries
1566590-77-9
Pharmaceutical Grade
99%
Guangzhou
Chunqiao
5mg 10mg 10vials
2026-07-04
peptide
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceAfamelanotide, a synthetic α-melanocyte stimulating hormone analog and first-in-class melanocortin-1 receptor agonist, has been approved in the EU for the prevention of phototoxicity in adults with erythropoietic protoporphyria (EPP)[1].Basic Info
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Product Name:
Afamelanotide acetate
Other Name:(Nle4,D-Phe7)-α-MSHAfaMelanotide, NDP-MSH, Melanotan 1, CUV1647;Afamelanotide acetate;Afamelanotide acetate, 10 mM in DMSO;Melanotan I acetate :Melanotan I;Melanotan 1 acetate
CAS No.:1566590-77-9
Molecular Formula:C80H115N21O21
InChIKeys:LBIUKNXYUXOWFF-CRYSLBJVSA-N
Molecular Weight:1706.93
Exact Mass:1705.85763976
EC Number:590-177-9
Categories:
Research-
Class:
Actin-sequestering protein / 43-amino-acid peptide
Status:Research compound — Not FDA approved (investigational: RGN-259 for dry eye / neurotrophic keratitis)
Mechanism:A naturally occurring 43-amino-acid peptide (Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH) that binds G-actin (sequesters monomeric actin), preventing F-actin polymerization. Promotes cell migration, angiogenesis, wound healing, and anti-inflammatory responses via integrin-linked kinase (ILK) and HIF-1α/VEGF pathways. TB-500 is the synthetic fragment Ac-LKKTETQ (MW ~895) often sold under this CAS.
Activity note:Thymosin Beta-4 is an actin-binding protein, not a receptor agonist. Functional activity is measured by actin sequestration (Kd ~0.7–1 μM) and cell migration assays, not EC₅₀.
Source:Goldstein AL, et al. Vitam Horm. 2003;66:257–296. RegeneRx RGN-259 clinical program.DOI
Clinical Development:
References-
DrugBank:PubChem:UNII:Disclaimer:
Thymosin Beta-4 (TB-500) is NOT FDA-approved for human therapeutic use. RGN-259 (Tβ4 ophthalmic solution) is an investigational drug not yet approved. TB-500 sold on research-chemical marketplaces is a synthetic fragment and is not an approved medicine. This listing is for industrial and laboratory research use only. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
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Seller Information
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Business Type:
Trader
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Main Products:
peptide
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Location:
Unit 1-B2141, 19B-F1, 81-1 Nonglinxia Road, Yuexiu District, Guangzhou, China
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Payment Terms:
100% TT in advance
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Year of Establishment:
2026
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted
Pakistan
Afamelanotide CAS1566590-77-9
1 G Jan 27, 2025 Post an enquiry for this product
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