I. Drug Class and Positioning
Mazdutide belongs to a new generation of:
👉 “Dual incretin receptor agonists”
It simultaneously activates two receptors:
GLP-1 receptor (GLP-1R)
Glucagon receptor (GCGR)
👉 Therefore, it is classified as a:
GLP-1 / Glucagon dual receptor agonist (dual agonist)
🧪 II. Mechanism of Action (Core Section)
1️⃣ GLP-1 Effects (“reducing intake”)
Suppresses appetite (acts on the central nervous system)
Delays gastric emptying
Enhances glucose-dependent insulin secretion
Lowers postprandial blood glucose
👉 Result: reduced food intake + improved glycemic control
2️⃣ Glucagon Effects (“increasing expenditure”)
Increases basal metabolic rate
Promotes fat oxidation
Enhances hepatic energy expenditure
👉 Result:
“The fat-burning engine” is activated
Weight Loss Efficacy
In the Phase II clinical trial of Mazdutide, patients in the 3mg, 4.5mg, and 6mg Mazdutide groups (administered once weekly) achieved an average weight reduction of 7.2%, 10.6%, and 11.6% respectively after 24 weeks of treatment. Results from the Phase III GLORY-1 trial showed that during the 48-week treatment period, the 6mg Mazdutide group had an average weight loss of 14.01%, while the placebo group only had a weight loss of 0.30%.
Improvement of Metabolic Indicators
Mazdutide not only effectively reduces weight but also comprehensively improves metabolic indicators. For example, in the Phase III clinical trial, the 6mg Mazdutide group saw an average reduction of 8.56mmHg in systolic blood pressure, a decrease of 0.65mmol/L in triglycerides, and a significant reduction in uric acid levels. Additionally, it showed a significant improvement effect on fatty liver, which can effectively reduce the pressure on the cardiovascular system and lower the risk of obesity-related complications.
Target Population
It is suitable for patients with simple obesity (BMI ≥ 28) and patients with a BMI of ≥ 24 who have one or more comorbidities, such as hyperglycemia, hypertension, dyslipidemia, fatty liver, and obstructive sleep apnea.
Q&A
Q: When can I receive the package?
A: It will be shipped as soon as possible after payment, and the shipping time is generally 7 to 15 days.
Q: What is the minimum amount I can order?
A: The minimum quantity we can order is 1 box, which contains 10 vials.
Q:How about the price? Can you make it cheaper?
A:We always take the customer's benefit as the top priority. Price is negotiable under different conditions, we are assuring you to get the most competitive price.
Q: How do i keep the peptides when i receive it ?
A: Peptides in the form of lyophilized powder can be transported at room temperature by vacuum packaging, while polypeptides in the dissolved state need to be refrigerated at 2°C - 8°C. For long-term storage, peptides should be stored in the form of lyophilized powder store at -20°C or -80°C in a sealed container with desiccant, which can avoid the degradation of peptides to the greatest extent.
Company Profile
HKX is a reliable manufacturer and exporter of peptide raw materials.
We have strong R&D capabilities and advanced production facilities. Our products cover various synthetic peptides and related raw materials, which are widely used in scientific research and pharmaceutical development. Every batch of goods undergoes rigorous laboratory testing to meet international quality standards.
We have years of international trade experience and a complete logistics system. Neutral packaging is used for all goods to comply with international shipping regulations. We provide flexible order solutions for customers, from small trial orders to large bulk purchases.
Sticking to the philosophy of Quality Priority and Customer Oriented, we sincerely welcome customers from all over the world to negotiate business and create win-win cooperation.
Why Choose Us
·Ultra-High Purity Each batch is synthesized and purified to >99% purity (HPLC), ensuring reliable and reproducible results in sensitive experiments.
·Accurate Dosing & Consistency Our peptides are precisely weighed and vacuum-sealed under sterile conditions. Batch-to-batch consistency is rigorously maintained.
·Endotoxin-Free & Sterile Processing Manufactured in a cleanroom environment, our peptides are free from endotoxins, microbial contamination, and other impurities that could interfere with cell-based or in vivo studies.
·Retail and bulk orders are accepted.
·Neutral packaging with full sealing for safe international shipping.
·Fast dispatch within 1-3 working days after payment confirmation.
Contact Us
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We provide dedicated service for all clients.