TSM | Peptides for Advanced Research| 99% Lyophilized Powder for Weight Loss

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This compound operates through selective engagement with cell surface receptors that modulate intracellular second messenger systems. Upon binding, it initiates downstream signaling cascades that promote cellular repair processes and regulate inflammatory mediators. Research indicates that TSM enhances mitochondrial function and supports protein synthesis pathways, thereby facilitating tissue regeneration and maintaining physiological equilibrium during periods of stress or metabolic challenge.

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Triple Agonist Design :

GLP-1 receptor: Retatrutide delays gastric emptying, suppress appetite, and promote secretion.

GIP receptor: Retatrutide enhances sensitivity and regulate central satiety signals.

Glucagon receptor (GCGR): Retatrutide activates liver energy metabolism, promote lipolysis and glycogenolysis, and increase basal metabolic rate.

The triple synergistic effect increases energy consumption while reducing energy intake, significantly improving weight loss effects.

Mechanism of Action and Molecular Structure of Retatrutide:

1)Triple Agonist Design
- GLP-1 receptor: Retatrutide delays gastric emptying, suppress appetite, and promote secretion.
- GIP receptor: Retatrutide enhances insulin sensitivity and regulate central satiety signals.
- Glucagon receptor (GCGR): Retatrutide activates liver energy metabolism, promote lipolysis and glycogenolysis, and increase basal metabolic rate.
The triple synergistic effect increases energy consumption while reducing energy intake, significantly improving weight loss effects.

2) Structural Optimization
- Based on the GIP skeleton modification, non-natural amino acids (such as α-methylleucine at position 13) are introduced to enhance receptor affinity.
- The half-life is extended to 7 days through fatty acid side chain modification