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Isotaxiresinol

Name: Isotaxiresinol
Brand: Cuicheng Bio
SKU: pr2606081149
Price: 200000 USD
Availability: InStock

Unit Price:

$200000-220000/G FOB

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CAS No.:

26194-57-0

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

5mg

Price valid (until):

2026-07-08

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Description
Seller Information

Description

Isotaxiresinol is a naturally occurring aryltetralin-type lignan found primarily in the heartwood and xylem of plants within the Taxus genus, such as the Yunnan yew (Taxus yunnanensis). Its primary functions include preventing and treating osteoporosis, providing potent hepatoprotection, mitigating inflammatory responses, and acting as a strong free radical scavenger.

1. Anti-Osteoporotic Activity and Bone Protection

Prevention of Bone Loss: In postmenopausal osteoporosis models (ovarietomized / OVX rats), isotaxiresinol functions as a promising anti-osteoporotic drug candidate. It significantly increases total bone mineral density (BMD) and cortical bone mineral content.
Inhibition of Bone Resorption: Its main mechanism of action involves selectively suppressing osteoclast-mediated bone resorption while slightly supporting osteoblast-mediated bone formation, thereby preserving the structural and mechanical integrity of the bone matrix.
No Uterine Side Effects: Unlike traditional estrogen replacement therapy (ERT), isotaxiresinol exerts its anti-bone-loss functions without causing undesirable stimulatory or hypertrophic side effects on uterine tissues.

2. Potent Hepatoprotection and Anti-Apoptotic Activity

Blocking Hepatocyte Apoptosis: Isotaxiresinol exhibits exceptional liver-protective functions. It suppresses the production of tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) in lipopolysaccharide (LPS)-activated macrophages, directly blocking the TNF-α-dependent pathway of hepatocyte apoptosis. This unique mechanism makes it a key target of interest for treating viral hepatitis, severe acute liver injury, and inflammatory hepatic complications.

3. Antioxidant and Anti-Inflammatory Properties

Free Radical Scavenging: Packed with multiple phenolic hydroxyl groups, isotaxiresinol displays outstanding DPPH free radical scavenging activity. It acts as a powerful antioxidant that reduces intracellular oxidative stress and significantly inhibits LPS-induced nitric oxide (NO) production in murine macrophage cells, calming systemic inflammatory cascades.

4. Botanical Defense and Synthetic R&D Utility

Plant Chemical Defense Matrix: Within Taxus species, isotaxiresinol behaves as a secondary metabolite functioning as a natural phytoalexin. Concentrated heavily in the heartwood, it protects the tree against wood-decaying fungi, pathogenic bacteria, and wood-boring insects.
Substrate for Enzymatic Modification: In medicinal chemistry, its stable structure and natural abundance make it an ideal acceptor molecule for enzymatic transgalactosylation reactions mediated by enzymes like β-galactosidase.

Basic Info

Product Name:

ISOTAXIRESINOL

Other Name:

ISOTAXIRESINOL

CAS No.:

26194-57-0

Molecular Formula:

C19H22O6

InChIKeys:

GQLVRVYXAHDDLB-PJFSTRORSA-N

Molecular Weight:

346.37438

Exact Mass:

346.142

Categories:

Lignans

Characteristics

PSA:

110

XLogP3:

1.7

Density:

1.348±0.06 g/cm3(Predicted)

Melting Point:

171 °C

See More ISOTAXIRESINOL Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More ISOTAXIRESINOL Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

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Product Name	Grade / Content	Price	Supplier Name	Details
Isotaxiresinol	Pharmaceutical grad/99	$100/KG EXW	Wuhan Pnq Int Trade Co., Ltd	Inquiry