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Cytisinicline

Name: Cytisinicline
Brand: Cuicheng Bio
SKU: pr2606081167
Price: 40 USD
Availability: InStock

3 Inquiries

Unit Price:

$40-50/G FOB

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CAS No.:

485-35-8

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

250mg

Price valid (until):

2026-07-08

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Description
Seller Information
Inquiry History

Description

Cytisinicline (also known as cytisine) is a plant-based alkaloid that primarily functions as a highly selective partial agonist of α₄β₂ nicotinic acetylcholine receptors (nAChRs). Its core clinical purpose is to act as a first-line prescription pharmacotherapy for smoking cessation and nicotine de-escalation.

Natively derived from the seeds of the golden rain tree (Cytisus laburnum), cytisinicline utilizes a dual-action biochemical mechanism to break nicotine dependence:

1. Dual-Action Biochemical Mechanism

Partial Agonist Action (Easing Withdrawal): Cytisinicline binds directly to the α₄β₂ nicotinic receptors in the brain—the same primary receptors targeted by nicotine. It stimulates these receptors at a lower baseline intensity than nicotine does, triggering a moderate release of dopamine. This sustained, low-level stimulation significantly reduces the physical cravings and severe withdrawal symptoms that occur when quitting smoking or vaping.
- Antagonist Action (Blocking the Reward): Because cytisinicline possesses an exceptionally high binding affinity, it physically blocks nicotine from attaching to the nicotinic receptors. If a patient experiences a lapse and smokes a cigarette or uses an e-cigarette during treatment, the inhaled nicotine cannot reach the blocked receptors. Consequently, the individual does not experience the usual dopamine "rush" or reinforcing satisfaction, helping to extinguish the addictive behavior over time.
2. Clinical Indications and Development Status
- Smoking Cessation: The principal indication for cytisinicline is treating severe tobacco dependence. Large-scale Phase 3 clinical trials (such as the ORCA-2 and ORCA-3 trials) have demonstrated that a standardized regimen (typically 3 mg three times daily for 6 to 12 weeks) significantly elevates continuous smoking abstinence rates compared to placebos.
- Vaping (E-Cigarette) Cessation: Cytisinicline has been granted a Breakthrough Therapy designation by the FDA to address the lack of authorized prescription options for nicotine e-cigarette users. It functions identically to lower vaping urges and ease cessation in young adults and long-term vapers.
- COPD-Specific Intervention: Post hoc trial data show that cytisinicline is uniquely functional for individuals with Chronic Obstructive Pulmonary Disease (COPD), offering a safe path to smoke cessation in a high-risk group vulnerable to standard stimulant-like cessation drugs.

Basic Info

Product Name:

Cytisine

Other Name:

1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one,1,2,3,4,5,6-hexahydro-,(1R,5S)-;Cytisine;1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one,1,2,3,4,5,6-hexahydro-,(1R)-;(1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one;Baptitoxin;Baptitoxine;Cytiton;Cytitone;Sophorine;Ulexine;Tabex;Ulexin;Laburnin;Sophorin;(-)-Cytisine;Cytisin;Tsitafat;Cytisinicline;3728-36-7;1267572-93-9;1932311-41-5;1933793-08-8;2308481-87-8

CAS No.:

485-35-8

Molecular Formula:

C11H14N2O

InChIKeys:

InChIKey=ANJTVLIZGCUXLD-UHFFFAOYSA-N

Molecular Weight:

190.24

Exact Mass:

190.24

EC Number:

207-616-0

UNII:

53S5U404NU

NSC Number:

407282

Color/Form:

Orthorhombic prisms from acetone|Solid

ATC Code:

N - Nervous system

HScode:

2933990090

Categories:

Plant Extracts

Characteristics

PSA:

32.3

XLogP3:

0.2

Appearance:

light yellow powder

Density:

1.2±0.1 g/cm3

Melting Point:

152-153 °C

Boiling Point:

218 °C @ Press: 2 Torr

Flash Point:

203.6±25.7 °C

Refractive Index:

1.623

Water Solubility:

439g/L(16 ºC)

Storage Conditions:

Store at RT

Vapor Pressure:

7.61X10-6 mm Hg at 25 deg C (est)

Toxicity:

LD50 in mice (mg/kg): 1.73 i.v.; 9.4 i.p.; 101 orally (Barlow, McLeod)

Specific rotation:

D17 -120°

Henrys Law Constant:

Henry's Law constant = 4.01X10-12 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

pK1 = 6.11; pK2 = 13.08

Collision Cross Section:

137.9 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Experimental Properties:

Deliquescent crystals, soluble in water and alchol. pH of 0.1 molar aqueous solution = 4.3 /Cytisine hydrochloride/|Hydroxyl radical reaction rate constant = 8.59X10-11 cu cm/molec-sec at 25 °C (est)

See More Cytisine Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

In original packages, in dry, and light-protected premises at temperature of 15 deg C to 25 deg C (60 - 75 deg F)

See More Cytisine Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Year of Establishment:
2019

Inquiry History

3 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Cytisine	5	Feb 1, 2024
Switzerland	Cytisin	1000 KG	Jun 28, 2023
Switzerland	Cytisin powder	1 MT	Jun 26, 2023

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