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H-Lys(Me)-OH

Name: H-Lys(Me)-OH
Brand: Cuicheng Bio
SKU: pr2606081178
Price: 5000 USD
Availability: InStock

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CAS No.:

1188-07-4

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

Price valid (until):

2026-07-08

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Description
Seller Information

Description

H-Lys(Me)-OH (also known as $N^{\epsilon }$-methyl-L-lysine or N⁶-methyl-L-lysine; CAS 1188-07-4) functions primarily as a histone code mimic, a metabolic probe for epigenetic enzymes, and a specialized building block in peptide synthesis and drug discovery.

It is the naturally occurring derivative of L-lysine where the side-chain ε-amino group is monomethylated.

Core Functions and Research Applications

Epigenetics and Chromatin Remodeling: Methylation of lysine residues on histone tails (e.g., H3K4me1, H3K9me1) is a fundamental post-translational modification (PTM) that directly regulates gene transcription and chromatin structure. H-Lys(Me)-OH is widely utilized to synthesize artificial histone peptides, functioning as a biomimetic probe to study how downstream "reader" proteins recognize and bind specific methylated states.
Substrate for Methylation Enzymes: It serves as a vital tool in biochemical assays to profile the activity of lysine methyltransferases (KMTs) and lysine demethylases (KDMs). Because dysregulation of these enzymes is linked to oncogenesis, this compound helps screen and optimize small-molecule epigenetic inhibitors in cancer research.
Study of Non-Histone Methylation: Many critical non-histone proteins (such as the p53 tumor suppressor) undergo lysine monomethylation, which alters their stability and cellular localization. Researchers use H-Lys(Me)-OH as a reference standard to track and map these non-histone signaling pathways.
Building Block for Solid-Phase Peptide Synthesis (SPPS): Once properly protected (for instance, converted into derivatives like Fmoc-Lys(Me)(Boc)-OH), it functions as a highly precise chiral monomer. It allows synthetic chemists to site-specifically introduce a monomethylated lysine into therapeutic peptides or macrocycles, often enhancing their metabolic stability against proteolysis.

ECHEMI Editorial Reference

Solid
N(6)-methyl-L-lysine is an L-lysine derivative that is L-lysine in which one of the hydrogens attached to N(6) is substituted by a methyl group. It is a L-lysine derivative and a non-proteinogenic L-alpha-amino acid. It is a conjugate base of a N(6)-methyl-L-lysinium(1+).

Basic Info

Product Name:

ε-Methyl-L-lysine

Other Name:

L-Lysine,N6-methyl-;Lysine,N6-methyl-,L-;Lysine,N6-methyl-;N6-Methyl-L-lysine;Nε-Methyllysine;ε-N-Methyllysine;N6-Methyllysine;ε-Methyl-L-lysine;ε-N-Methyl-L-lysine;Monomethyllysine;Nε-Methyl-L-lysine;ε-Methyllysine;6-N-Methyllysine;16105-95-6

CAS No.:

1188-07-4

Molecular Formula:

C7H16N2O2

InChIKeys:

InChIKey=PQNASZJZHFPQLE-LURJTMIESA-N

Molecular Weight:

160.21

Exact Mass:

160.21

DSSTox ID:

DTXSID70152242

Categories:

Bulk Drug Intermediates

Characteristics

Collision Cross Section:

132.5 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|134.21 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More ε-Methyl-L-lysine Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

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H-Lys(Me)-OH

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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