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Praeruptorin A

Name: Praeruptorin A
Brand: Cuicheng Bio
SKU: pr2606011574
Price: 18000 USD
Availability: InStock

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CAS No.:

73069-25-7

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

g/kg

Price valid (until):

2026-07-03

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Description
Seller Information

Description

Praeruptorin A (PA) is a major, naturally occurring angular pyranocoumarin primarily extracted from the dried roots of Peucedanum praeruptorum Dunn (known as White-flower Qianhu in Traditional Chinese Medicine). Its fundamental functions in the body center on calcium channel blockade, relaxing smooth muscles, suppressing airway hyperresponsiveness, and relieving bone-resorption disorders. [1, 2, 3]

While it shares an herbal origin with its sibling isomer, Praeruptorin B, Praeruptorin A is uniquely recognized as a potent, dual-enantiomer calcium antagonist.

Core Health Functions

Acts as a Calcium Channel Blocker (CCB): It functions as a novel calcium influx blocker. By obstructing calcium ions from flooding into smooth muscle cells, it prevents sustained muscle contractions and promotes direct vasorelaxation. [1, 2, 3]
Alleviates Asthma and Airway Hyperresponsiveness: It effectively relaxes tracheal smooth muscles and reduces allergic airway inflammation. Preclinical trials show it downregulates asthma-triggering cytokines (like IL-4, IL-5, and IL-13), helping clear pulmonary congestion and ease breathing spasms. [1, 2, 3, 4, 5]
Lowers Blood Pressure & Protects the Heart: Thanks to its calcium-blocking pathways, it dilates blood vessels, reduces arterial pressure, and improves myocardial systolic and diastolic compliance. It also shields the heart muscle from ischemia-reperfusion injuries. [1, 2, 3, 4]
- Inhibits Bone Erosion: It targets bone-resorption disorders by suppressing the RANKL-induced migration and fusion of preosteoclasts. It accomplishes this by binding to calcium/calmodulin complex proteins, thereby shutting down the downstream NFATc1 signaling pathway that triggers bone breakdown. [1]
- Suppresses Systemic Inflammation: It halts acute cellular inflammation by blocking the NF-κB signaling pathway and suppressing the expression of pro-inflammatory factors (such as IL-1$\beta $ and PTGS2/COX-2). [1, 2, 3]
- Reverses Multidrug Resistance (MDR) in Tumors: In oncology studies, Praeruptorin A serves as a potent modulator of P-glycoprotein (P-gp). P-gp is an efflux pump that tumor cells overexpress to pump out chemotherapy drugs; by blocking this pump, Praeruptorin A keeps anticancer therapies trapped inside target cells at cytotoxic concentrations. [1, 2, 3, 4, 5]

Basic Info

Product Name:

Praeruptorin A

Other Name:

PRAERUPTORIN A;2-Butenoicacid, 2-methyl-, (9S, 10S)-10-(acetyloxy)-;9,10-dihydro-8,8-dimethyl-2-oxo-2H, 8H-;DL-Praeruptorin A;Praeruptorin ADL-Praeruptorin A

CAS No.:

73069-25-7

Molecular Formula:

C21H22O7

Molecular Weight:

386.398

Exact Mass:

386.136566

HScode:

29329990

Categories:

Plant Extracts

Characteristics

PSA:

92.04000

XLogP3:

4.18

Density:

1.3±0.1 g/cm3

Boiling Point:

486.8±45.0 °C at 760 mmHg

Flash Point:

211.5±28.8 °C

Refractive Index:

1.574

See More Praeruptorin A Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Praeruptorin A Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

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Praeruptorin A

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

More Choices Find All Products for Sale 

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