4-ETHOXYPHENYLACETIC ACID.

Uses: p-Ethoxyphenylacetic acid is an important intermediate in the synthesis of pesticides, pharmaceuticals, and liquid crystal materials, and it is also a widely used fuel additive internationally. Main synthesis routes: The documented synthesis routes for p-ethoxyphenylacetic acid mainly include three methods: (1) Using phenethyl ether as the raw material, it undergoes chloromethylation, cyanation, hydrolysis, and acidification to obtain the product; (2) p-Cresol reacts with diethyl sulfate through Williamson etherification, then goes through chlorination, cyanation, hydrolysis, and acidification to yield the product; (3) p-Ethoxyphenylacetone reacts with elemental sulfur and amine compounds through the Willgerodt amide rearrangement, followed by hydrolysis to obtain the product. Among these, routes 1 and 2 have long processes, intermediate products are difficult to separate, and both use the highly toxic sodium cyanide; route 3 has fewer steps but requires a long reaction time and has a low yield.

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