Mazdutide 10mg Raw Powder CAS Number 2259884-03-0 Door To Door Service...

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Mazdutide is an innovative therapeutic agent with the following details:
English name: Mazdutide CAS number: 2259884-03-0 Mazdutide is a GLP-1R/GCGR dual receptor agonist developed by Innovent Biologics, intended for the long-term weight management of adult patients with obesity or overweight. Mechanism of Action Mazdutide innovatively adopts a dual receptor agonist mechanism. On one hand, it activates GLP-1R to promote insulin secretion, suppress appetite, and delay gastric emptying, thereby reducing food intake. On the other hand, it activates GCGR to promote fat oxidation and energy expenditure. This two-pronged approach enhances the ability to reduce weight and regulate metabolism. Weight Loss Efficacy In the Phase II clinical trial of Mazdutide, patients in the 3mg, 4.5mg, and 6mg Mazdutide groups (administered once weekly) achieved an average weight reduction of 7.2%, 10.6%, and 11.6% respectively after 24 weeks of treatment. Results from the Phase III GLORY-1 trial showed that during the 48-week treatment period, the 6mg Mazdutide group had an average weight loss of 14.01%, while the placebo group only had a weight loss of 0.30%. Improvement of Metabolic Indicators Mazdutide not only effectively reduces weight but also comprehensively improves metabolic indicators. For example, in the Phase III clinical trial, the 6mg Mazdutide group saw an average reduction of 8.56mmHg in systolic blood pressure, a decrease of 0.65mmol/L in triglycerides, and a significant reduction in uric acid levels. Additionally, it showed a significant improvement effect on fatty liver, which can effectively reduce the pressure on the cardiovascular system and lower the risk of obesity-related complications. Target Population It is suitable for patients with simple obesity (BMI ≥ 28) and patients with a BMI of ≥ 24 who have one or more comorbidities, such as hyperglycemia, hypertension, dyslipidemia, fatty liver, and obstructive sleep apnea.

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