Gemfibrozil CAS 25812-30-0 Gemfibrozil for Treatment of Hyperlipidemia
COA TDS 2 Inquiries
25812-30-0
Pharmaceutical Grade
99%
shenzhen
HS
25kg drum
2026-07-10
Ivermectin,Active pharmaceutical ingredients,Cosmetics material,Chemical intermediate,Nootropic,Food additive
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceGemfibrozil is an activator of PPAR-α, used as a lipid-lowering drug; Gemfibrozil is also a nonselective inhibitor of several P450 isoforms, with Ki values for CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, respectively.
Gemfibrozil is a peroxisome proliferator-activated receptor α (PPARα) and PPARγ agonist (EC50s = 193.3 and 147.8 μM, respectively, in transactivation assays).In vivo, gemfibrozil (50 mg/kg, p.o.) reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil (100 mg/kg per day) reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif ligand 2 (CCL2) inApoE-/-mice. Formulations containing gemfibrozil have been used in the treatment of high cholesterol.
White Crystalline Powder
ChEBI: Gemfibrozil is an aromatic ether. It has a role as an antilipemic drug. It is functionally related to a valeric acid.
Gemfibrozil, 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid (Lopid), is a congener of clofibratethat was used first in the treatment of hyperlipoproteinemia inthe mid-1970s. Its mechanism of action and use are similar tothose of clofibrate. Gemfibrozil reduces plasma levels ofVLDL triglycerides and stimulates clearance of VLDL fromplasma. The drug has little effect on cholesterol plasma levelsbut does cause an increase of HDL.Gemfibrozil is absorbed quickly from the gut and excretedunchanged in the urine. The drug has a plasma half-life of1.5 hours, but reduction of plasma VLDL concentration takesbetween 2 and 5 days to become evident. The peak effect of its hypolipidemic action may take up to 4 weeks to becomemanifest.CertificatesBasic Info-
Product Name:
Gemfibrozil
Other Name:PENTANOIC ACID, 5-(2,5-DIMETHYLPHENOXY)-2,2-DIMETHYL-;5-(2,5-DIMETHYLPHYLPHENOXY)-2,2-DIMETHYLPENTANOIC ACID;5-(2,5-DIMETHYL-PHENOXY)-2,2-DIMETHYL-PENTANOIC ACID;2,2-DIMETHYL-5-[2,5-DIMETHYL-PHENOXY]PENTANOIC ACID;2,2-DIMETHYL-5-(2,5-XYLYLOXY) VALERIC ACID;GEMFIBROZIL;Gemcitabine intermediates;5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic Acid, CI-719, Decrelip, Genlip, Gevilon, Lipozid, Lpur, Lopid
CAS No.:25812-30-0
Molecular Formula:C15H22O3
InChIKeys:HEMJJKBWTPKOJG-UHFFFAOYSA-N
Molecular Weight:250.33
Exact Mass:250.33
EC Number:247-280-2
Color/Form:White to Off-White
HScode:2918992090
Categories:
Characteristics-
PSA:
46.5
XLogP3:3.8
Appearance:Solid
Density:1.1109 (rough estimate)
Melting Point:61-63°C
Boiling Point:158-159 C
Flash Point:141.6±18.1 °C
Refractive Index:1.5020 (estimate)
Water Solubility:>0.5g/L(temperature not stated)
Storage Conditions:-20°C Freezer
Vapor Pressure:3.1X10-5 mm Hg at 25 deg C (est)
Toxicity:LD50 in mice, rats (mg/kg): 3162, 4786 orally (Kurtz)
PKA:4.75±0.45(Predicted)
Critical Temperature & Pressure:2-8°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Carcinogenicity, Category 1B
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s)
Signal word Danger
Hazard statement(s) H302 Harmful if swallowed
H350 May cause cancer
H361 Suspected of damaging fertility or the unborn child
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Commercially available gemfibrozil tablets should be stored in tight containers at a temperature less than 30 deg C.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Ivermectin,Active pharmaceutical ingredients,Cosmetics material,Chemical intermediate,Nootropic,Food additive
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Location:
6 floor Baoyilongji Building B Weiyang Area, Fengcheng 8 Road, Xi'an city, Shaanxi, 710000, China
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Payment Terms:
L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7 days
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Total Annual Revenue:
$5 million-$10 million
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Total Employees:
51-100
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Year of Establishment:
2017
Company Certificates-
ISO
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ISO
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Inquiry History2 Inquiries
Country Product Purchase Quantity Date Posted
Vietnam
Gemfibrozil
1 MT Jun 10, 2026
Pakistan
Gemfibrozil
500 KG Oct 21, 2025 Post an enquiry for this product
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