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Home > Food Additives > Nutrition Supplements > Calciuml-5-Methyltetrahydrofolate for Sale > Top quality L-5-Methyltetrahydrofolate Calcium
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Top quality L-5-Methyltetrahydrofolate Calcium

TDS 6 Inquiries

Unit Price:

$990-1200/KG FOB

Get Latest Price
CAS No.:

151533-22-1

Grade:

Food Grade

Content:

98%

Port:

Shenzhen

Brand:

JaYoo

Packaging:

25kg per drum

Price valid (until):

2026-12-31

Company Type:
Trader
Location:
China
Qualification:
Main Products:

Fisetin,Coenzyme PQQ,S-Acetyl L-Glutathione,D-Glucosamine Hydrochloride Powder Glucosamine Sulfate Potassium Chloride Powder,MSM Powder,Sodium Hyaluronate Powder

  • Product Description

  • Seller Information

  • Inquiry History

  • Description


    What is L-5-Methyltetrahydrofolate Calcium?  


    L-5-Methyltetrahydrofolate Calcium (L-5-MTHF-Ca) is the natural active form of folic acid (vitamin B9). Regular folic acid requires multiple metabolic steps to convert into 5-methyltetrahydrofolate before it can function, whereas L-5-Methyltetrahydrofolate Calcium can be directly absorbed and utilized by the body without the need for MTHFR enzyme metabolism or hepatic metabolic activation. It is suitable for individuals with MTHFR gene metabolic disorders, middle-aged and elderly populations, as well as those requiring cardiovascular maintenance. It serves as an upgraded alternative to conventional folic acid.


    Product name: L-5-Methyltetrahydrofolate Calcium

    CAS # 151533-22-1

    Formula C20H23CaN7O6

    Formula Weight 497.5 2

    EINECS # 691-636-3

    Purity 9 8 %

    Package size 25KG/drum

    Shop Top quality L-5-Methyltetrahydrofolate Calcium-Detailed Image 1

    Test Items

    Specification

    Appearance

    White to Light yellow powder

    Purity

    98%

    Identification

    The infrared absorption spectrum of the sample is consistent with the infrared absorption spectrum of the reference material.

    Water

    6.0-17.0%

    Calcium

    7.0%-8.5%

    Chloride

    0.5%

    Elemental impurities

    Platinum 10ppm

    Elemental impurities

    Boron 20ppm

    Elemental impurities

    Arsenic   1.5ppm

    Elemental impurities

    Cadmium  0.5ppm

    Elemental impurities

    Lead    1. ppm

    Elemental impurities

    Mercury 1.5ppm

    Enantiomeric purity

    D-5-methyltetrahydrofolate 1.0%

    Related compounds

    4a-Hydroxy-5-methyltetrahydrofolic acid  1.0%

    Related compounds

    Single impurity 0.5%

    Related compounds

    Total impurities 2.5%




      Product Mechanism of  MTHF 


    L-5-methyltetrahydrofolate calcium, as the active form of folate, does not need to be catalyzed by MTHFR enzyme after entering the human body. It can directly participate in the metabolism of one carbon unit in the body, participate in nucleic acid and protein synthesis to promote red blood cell production, improve megaloblastic anemia, and promote the conversion of homocysteine , reducing the level of homocysteine in the blood and reducing the risk of cardiovascular and cerebrovascular damage; At the same time, it can assist in the normal differentiation and development of neural tubes during embryonic development, avoid fetal congenital defects.


    Advantage of MTHF


    1) High utilization rate: Ordinary folic acid needs to be converted into its active form by liver MTHFR enzyme before it can be utilized; L-5-MTHF Ca does not require metabolism and is directly absorbed by the intestine, making it particularly suitable for individuals with MTHFR gene metabolic disorders.

    2) Higher safety: It does not produce 'unmetabolized folate' and does not mask the risk of vitamin B12 deficiency.

    3) Good stability:stability is better than ordinary active folic acid, increasing  the shelf life of the finished products.


    What food contains methyltetrahydrofolate


    1. 5- methyltetrahydrofolate (active folate) is present in various natural foods, including green leafy vegetables such as spinach, amaranth, rapeseed, lettuce, and kale; Beans/bean products such as soybeans, black beans, soybean milk; Nuts such as sunflower seeds, walnuts, cashews, and almonds; Grains such as oats, brown rice, and whole wheat bread; Fruits such as oranges, strawberries, cherries, and avocados; Animal liver, beef liver, eggs, and meat products all contain methyltetrahydrofolate.


     What product could be used with MTHF for better result


    1) L-5-methyltetrahydrofolate combined with vitamins B6 and B12 synergistically metabolizes homocysteine, doubling the effectiveness of maternal and infant care and vascular protection.

    2) L-5-methyltetrahydrofolate calcium combined with iron element can double improve anemia.

    3) L-5-methyltetrahydrofolate calcium, combined with betaine, fish oil, and coenzyme Q10, provides multidimensional protection for vascular health.

    4) L-5-methyltetrahydrofolate calcium complex with magnesium, theanine, and B vitamins can soothe emotions and care for mental health.


     Potentical efficacy of MTH 


    Some studies suggest that L-5-methyltetrahydrofolate calcium has the following potential benefits:

    1) Preventing birth defects: Supplementing in early pregnancy can participate in the development of the fetal nervous system, reduce the risk of fetal neural tubes, and is a key nutrient for women preparing for pregnancy and during pregnancy.

    2) Cardiovascular and cerebrovascular health: reducing homocysteine levels to prevent stroke and coronary heart disease.

    3) Improving anemia: Participate in hemoglobin synthesis to prevent megaloblastic anemia.

    4) Neurological and emotional health: synthesizes serotonin and dopamine, relieves anxiety and depression, and protects cognition.


     Jayoo Advantage


    • Low MOQ, flexible support for small-scale trial orders
    • Customization package to meet diverse needs
    • Strict control of quality, supporting free samples
    • Support authoritative third-party testing, such as SGS and Eurofins.etc


      Application of MTHF  


    Dietary supplements: active folic acid tablets, multivitamins.

    Food & beverage : Blended Milk Powder, Solid Beverages

    Skincare products: participate in amino acid metabolism, improve skin barrier

    Shop Top quality L-5-Methyltetrahydrofolate Calcium-Detailed Image 2


      How to purchase L-5-methyltetrahydrofolate calcium?


    As a high-quality producer of L-5-methyltetrahydrofolate calcium in China, we can provide stable and reliable L-5-methyltetrahydrofolate calcium raw materials for industries such as health products, cosmetics, and food production. We have a highly competitive pricing system and can provide exclusive quotes based on your bulk orders, providing cost-effective solutions for enterprises of all sizes. Simultaneously supporting formula and packaging customization to meet your personalized production needs. We are willing to become your trusted long-term partner of L-5-methyltetrahydrofolate calcium. Welcome to call or write to discuss cooperation and place orders.

    Shop Top quality L-5-Methyltetrahydrofolate Calcium-Detailed Image 3
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    Certificates

    Basic Info
    Product Name:

    Calciuml-5-Methyltetrahydrofolate

    Other Name:

    levomefolate calcium;metafolin;N-(4-(((2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid calcium salt;safyral;Calcium levomefolate;Levomefolate (calcium);UNII-A9R10K3F2F;LMCA;Levomefolinate calcium

    CAS No.:

    151533-22-1

    Molecular Formula:

    C40H48CaN14O12

    InChIKeys:

    VWBBRFHSPXRJQD-QNTKWALQSA-L

    Molecular Weight:

    95697372

    Exact Mass:

    497.133575

    HScode:

    29339900

    Categories:

    Nutrition Supplements

    Characteristics
    PSA:

    204 Ų

    Melting Point:

    >300°C

    Storage Conditions:

    -20°C Freezer

    Hazard Identification

    Classification of the substance or mixture

    Acute toxicity - Category 4, Oral

    Skin irritation, Category 2

    Eye irritation, Category 2

    Specific target organ toxicity – single exposure, Category 3

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Warning

    Hazard statement(s)

    H302 Harmful if swallowed

    H315 Causes skin irritation

    H319 Causes serious eye irritation

    H335 May cause respiratory irritation

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P271 Use only outdoors or in a well-ventilated area.

    Response

    P301+P317 IF SWALLOWED: Get medical help.

    P330 Rinse mouth.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P321 Specific treatment (see ... on this label).

    P332+P317 If skin irritation occurs: Get medical help.

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    P319 Get medical help if you feel unwell.

    Storage

    P403+P233 Store in a well-ventilated place. Keep container tightly closed.

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Fisetin,Coenzyme PQQ,S-Acetyl L-Glutathione,D-Glucosamine Hydrochloride Powder Glucosamine Sulfate Potassium Chloride Powder,MSM Powder,Sodium Hyaluronate Powder

    Location:

    7C92B, Building 213, Tairan Science and Technology Park, No. 113 Tairan 4th Road, Tian'an Community, Shatou Subdistrict, Futian District, Shenzhen City

    Payment Terms:

    TT against copy of documents,100% TT in advance

    Average lead Time:

    10

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    5-10

    Year of Establishment:

    2025

    Shenzhen Jayoo Biotech Co., Ltd. is an emerging high-tech enterprise dedicated to the field of biological health. We are committed to delivering natural, safe, and highly effective health products and solutions to global markets.

    Our core strength lies in a professional team with over a decade of deep industry experience in the bio-health sector. Composed of seasoned R&D specialists and market-driven professionals, our team combines strong technical expertise with innovative thinking and commercial insight. In parallel, we have established preliminary collaborations with leading domestic universities and research institutions, leveraging their advanced scientific resources to accelerate product development and technology commercialization—injecting strong momentum into our long-term growth.

    Jayoo Biotech focuses on innovation in natural active ingredient extraction and biosynthesis technologies. Guided by our R&D philosophy of “Natural, Safe, and Effective,” we integrate modern biotechnology with advanced plant extraction processes to build differentiated technological advantages. Our product development spans multiple health-related sectors, including natural active ingredients, functional raw materials, and nutritional supplements, with continuous innovation driving enhanced product competitiveness.

  • Inquiry History
    6 Inquiries
    Country Product Purchase Quantity Date Posted
    Paraguay

    calcium l-5-methyltetrahydrofolate

    100 G Feb 25, 2026
    United States

    Methyl folate , L methyle folate

    500 KG Mar 7, 2024
    United States

    L-5-Methyltetrahydrofolate Calcium

    200 KG Apr 27, 2026
    India

    levomefolate calcium

    100 KG Apr 9, 2026
    Pakistan

    CALCIUM L-5-METHYLTETRAHYDROFOLATE

    10 G Oct 9, 2024
    India

    inositol

    10.00 G Jul 21, 2025
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