High-quality Dihexa Hexanoyl-Tyr-Ile-Ahx-NH2 Modified Angiotensin IV Analog Widely Used in Neural Cell Culture
TDS 4 Inquiries
12020-86-9
Pharmaceutical Grade
99%
guangzhou
band
2mg/vial 10vials/box
2026-07-15
Tirzepatide,Retatrutide,Semaglutide,GHK-Cu
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceMGF stands for Mechano Growth Factor. MGF is a peptide for tissue repair that promotes the expansion of tissue stem cells. It is an insulin-like growth factor-1 (IGF-1) splice variant. Research suggests MGF promotes healthy tissue regeneration, wound repair, cardiac repair, and skeletal muscle recovery.Certificates
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TDS
Basic Info-
Product Name:
MGF
Other Name:MGF;Anti-STAT5A, C-Terminal antibody produced in rabbit;Mammary gland factor;STA5A;Anti-STAT5A antibody produced in rabbit;STAT5, His tagged human;STAT5A;MGF(5MG)
CAS No.:12020-86-9
Molecular Formula:FKLiMgO5Si2+
InChIKeys:URDVXLJHPPPBHL-UHFFFAOYSA-M
Molecular Weight:225.51
EC Number:200-001-8
Categories:
Characteristics-
Density:
2.85 g/cm3
Critical Temperature & Pressure:-20°C
Research-
Class:
Angiotensin IV-derived oligopeptide / HGF-c-Met potentiator
Status:Research compound — Not FDA approved
Mechanism:A synthetic, orally active, blood-brain-barrier-permeable oligopeptide (Hexanoyl-Tyr-Ile-Ahx-NH₂) derived from angiotensin IV. Dihexa binds hepatocyte growth factor (HGF) with high affinity (Kd = 65 pM) and allosterically potentiates HGF activity at its receptor c-Met, promoting dendritic spinogenesis and synaptogenesis. In preclinical models it was reported to be seven orders of magnitude more potent than BDNF at promoting synapse formation. Note: the foundational 2014 paper (McCoy AT, et al. Neurobiol Learn Mem. 2014) was retracted in 2025.
EC50 (HGF Binding KD):65 pM
Activity note:Dihexa is an HGF potentiator, not a direct receptor agonist. It does not activate c-Met alone but markedly augments HGF-induced c-Met activation at low nanomolar HGF concentrations. Functional synaptogenic activity was reported at 10⁻¹°–10⁻⁻ M (original data now subject to retraction).
Source:Original report: McCoy AT, et al. Neurobiol Learn Mem. 2014;115:112-120 (retracted 2025). Benoist CC, et al. J Pharmacol Exp Ther. 2014;351(3):628-637.
Clinical Development:
References-
PubChem:UNII:Literature:
Benoist CC, et al. J Pharmacol Exp Ther. 2014 — HGF/c-Met mechanism; McCoy AT, et al. Neurobiol Learn Mem. 2014 — Synaptogenesis data (Retracted 2025); Athira Pharma: Fosgonimeton (prodrug) pipeline status
Disclaimer:Dihexa is NOT FDA-approved or EMA-approved as a medicine. It is a research compound only. The foundational 2014 paper describing its synaptogenic potency was retracted in 2025. Its phosphate prodrug fosgonimeton failed a Phase 2/3 Alzheimer’s trial (LIFT-AD, 2024). This listing is for industrial and laboratory research use only. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
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Seller Information
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Business Type:
Trader
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Main Products:
Tirzepatide,Retatrutide,Semaglutide,GHK-Cu
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Location:
RM 701, UNIT 108, 7/F, TWR B NEW MANDARIN PLAZA 14 SCIENCE MUSEUM RD TSIM SHA TSUI HONG KONG
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Year of Establishment:
2026
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Inquiry History4 Inquiries
Country Product Purchase Quantity Date Posted
Australia
MGF
50 Dec 22, 2023
Philippines
MGF
10 MG May 26, 2026
United States
MGF POWDER (not vials)
1 G Mar 16, 2026
United States
factory hot sale MGF,Mechano grow factor 98% Powder IGF-1 EC 99% White powder with good price
1000 MT Nov 3, 2023 Post an enquiry for this product