BMN 673 CAS1207456-01-6
1207456-01-6
Industrial Grade
99%
SHANGHAI
Dideu
25kg/Cardboard Drum
2026-07-15
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
-
Product Description
-
Seller Information
-
DescriptionECHEMI Editorial ReferenceTalazoparib (BMN 673) is a novel PARP inhibitor with IC50 of 0.58 nM in a cell-free assay. It is also a potent inhibitor of PARP-2, but does not inhibit PARG and is highly sensitive to PTEN mutation. Phase 3.
Talazoparib was approved by the FDA for use in germline BRCA mutated, HER2 negative, locally advanced or metastatic breast cancer on October 16, 2018 under the trade name Talzenna. Talzenna was granted approval based on the results of the EMBRACA trial in which talazoparib resulted in a mean 8.6 months progression-free survival time versus physician's choice chemotherapy which resulted in 5.6 months progression-free survival.|Talazoparib is a Poly(ADP-Ribose) Polymerase Inhibitor. The mechanism of action of talazoparib is as a Poly(ADP-Ribose) Polymerase Inhibitor.|Talazoparib is an orally available small molecule inhibitor of the DNA repair enzyme poly ADP-ribose polymerase (PARP) which is used as an antineoplastic agent in the treatment of selected cases of breast cancer. Talazoparib is associated with a moderate rate of serum aminotransferase elevations during therapy and is suspected to cause rare instances of clinically apparent acute liver injury.|Talazoparib is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Talazoparib selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks.Basic Info-
Product Name:
Talazoparib
Other Name:3H-Pyrido[4,3,2-de]phthalazin-3-one,5-fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-,(8S,9R)-;(8S,9R)-5-Fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazin-3-one;Talazoparib;BMN 673;Talzenna
CAS No.:1207456-01-6
Molecular Formula:C19H14F2N6O
InChIKeys:InChIKey=HWGQMRYQVZSGDQ-HZPDHXFCSA-N
Molecular Weight:380.3508664
Exact Mass:380.35
UNII:9QHX048FRV
NCI Thesaurus Code:C95733
ATC Code:L01XX|L - Antineoplastic and immunomodulating agents
Categories:
Characteristics-
PSA:
84.2
XLogP3:1.4
Density:1.63
Refractive Index:1.775
Hazard IdentificationClassification of the substance or mixture
Germ cell mutagenicity, Category 2
Reproductive toxicity, Category 1B
Specific target organ toxicity â repeated exposure, Category 1
GHS label elements, including precautionary statements
Pictogram(s)
Signal word Danger
Hazard statement(s) H341 Suspected of causing genetic defects
H360 May damage fertility or the unborn child
H372 Causes damage to organs through prolonged or repeated exposure
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P318 IF exposed or concerned, get medical advice.
P319 Get medical help if you feel unwell.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Manufactory
-
Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
-
Location:
https://www.dideu.com/en/
-
Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
-
Average lead Time:
7 days
-
Total Annual Revenue:
Above $100 million
-
Total Employees:
Above 1000
-
Year of Establishment:
2016
Company Certificates-
ISO Certificate
-
REACH
">Company Profile -
-
Country Product Purchase Quantity Date Posted Post an enquiry for this product
More from this Seller
-
-
-
Bis(2-ethylhexyl) phthalate 99% Liquid Dideu
Industrial Grade / 99%
-
-
-
-
High Quality Sodium diacetate 99% powder 126-96-5-Shaanxi Dideu Medichem Co.Ltd
Chemical Grade / 99%
$1/KG FOB
-
-
-
-
High Quality Erdafitinib 99% powder 1346242-81-6-Shaanxi Dideu Medichem Co.Ltd
Chemical Grade / 99%
$1/G FOB
-
-
-
-
3-[[[(3,4-DICHLOROBENZOYL)AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID
Industrial Grade / 99.0%
-
-
-
-
Donepzil HCl,Donepezil Hydrochloride,120011-70-3
Industrial Grade / 99%
-