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pharmaceutical raw materials BMN 673 CAS 1207456-01-6 Talazoparib

Name: pharmaceutical raw materials BMN 673 CAS 1207456-01-6 Talazoparib
Brand: arshine
SKU: pr2311071318
Price: 32500 USD
Availability: InStock

Unit Price: Get Latest Price 

CAS No.:

1207456-01-6

Grade:

Pharmaceutical Grade

Content:

99.3%

Port:

SHANGHAI

Brand:

arshine

Packaging:

25KG

Price valid (until):

2023-12-07

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Arshine Group Co., Ltd.

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

cosmetic additives,Veterinary APIs,Feed additives,medical and pharmaceutical packaging materials,pharmaceutical equipment,Natural Nutrition Ingredients

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Product Description
Seller Information

Description

Shop Pharmaceutical Raw Materials CAS 864731-61-3 Fluralaner-Detailed Image 1

Talazoparib (BMN 673) is a novel PARP inhibitor with IC50 of 0.58 nM in a cell-free assay. It is also a potent inhibitor of PARP-2, but does not inhibit PARG and is highly sensitive to PTEN mutation. Phase 3.

Talazoparib was approved by the FDA for use in germline BRCA mutated, HER2 negative, locally advanced or metastatic breast cancer on October 16, 2018 under the trade name Talzenna. Talzenna was granted approval based on the results of the EMBRACA trial in which talazoparib resulted in a mean 8.6 months progression-free survival time versus physician's choice chemotherapy which resulted in 5.6 months progression-free survival.|Talazoparib is a Poly(ADP-Ribose) Polymerase Inhibitor. The mechanism of action of talazoparib is as a Poly(ADP-Ribose) Polymerase Inhibitor.|Talazoparib is an orally available small molecule inhibitor of the DNA repair enzyme poly ADP-ribose polymerase (PARP) which is used as an antineoplastic agent in the treatment of selected cases of breast cancer. Talazoparib is associated with a moderate rate of serum aminotransferase elevations during therapy and is suspected to cause rare instances of clinically apparent acute liver injury.|Talazoparib is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Talazoparib selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks.

Product Name	Talazoparib		Batch number	230901
CAS Number	1207456-01-6		Batch weight	210g
Molecular Formula	C1 9H 14F2N₆O		Mfg date	Sep,22,2023
Molecular Weight	380.36		Retest date	Sep,21,2025

TEST ITEMS		SPECIFICATION			RESULT
Descrption		White to off-white crystal powder			white crystal powder
Identification		BY HPLC			Complies
Melting point		247~249℃			247.5~248.5℃
Loss on drying		N.M.T 0.5%			0.2%
Residue on ignition		N.M.T 0.1%			0.03%
Purity (HPLC)		N.L.T 98.0%			99.3%
CONCLUSION		The product complies with the requirements of enterprise standard

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Basic Info

Product Name:

Talazoparib

Other Name:

3H-Pyrido[4,3,2-de]phthalazin-3-one,5-fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-,(8S,9R)-;(8S,9R)-5-Fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazin-3-one;Talazoparib;BMN 673;Talzenna

CAS No.:

1207456-01-6

Molecular Formula:

C19H14F2N6O

InChIKeys:

InChIKey=HWGQMRYQVZSGDQ-HZPDHXFCSA-N

Molecular Weight:

380.3508664

Exact Mass:

380.35

UNII:

9QHX048FRV

NCI Thesaurus Code:

C95733

ATC Code:

L01XX|L - Antineoplastic and immunomodulating agents

Categories:

Antineoplastic Agents

Characteristics

PSA:

84.2

XLogP3:

1.4

Density:

1.63

Refractive Index:

1.775

See More Talazoparib Properties 

Hazard Identification

Classification of the substance or mixture

Germ cell mutagenicity, Category 2

Reproductive toxicity, Category 1B

Specific target organ toxicity â repeated exposure, Category 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H341 Suspected of causing genetic defects H360 May damage fertility or the unborn child H372 Causes damage to organs through prolonged or repeated exposure
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray. P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P318 IF exposed or concerned, get medical advice. P319 Get medical help if you feel unwell.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Talazoparib Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
cosmetic additives,Veterinary APIs,Feed additives,medical and pharmaceutical packaging materials,pharmaceutical equipment,Natural Nutrition Ingredients

Location:
Block 14, No.100, Luyun Road,Changsha 410205,China.

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
15

Total Annual Revenue:
Above $100 million

Total Employees:
201-300

Year of Establishment:
2012

Certifications:
FAMI-QS,AEO,ISO9001

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Arshine Group Co., Ltd. (Arshine Group for short) was founded in Shenzhen in 2007. Over the decades, Arshine has maintained sound development and rapid global expansion with an average annual growth rate of over 30%. Based on China and looking at the world, the Group has become a first-class and industry-leading professional health industry chain service group in China, with an annual turnover of over $150million.
Arshine Group supplies more than 2,000 kinds of products, covering the whole field of health industry, including human APIs, veterinary APIs, food additives, natural nutrition ingredients, feed additives, cosmetic additives, intermediates, pharmaceutical equipment, medical and pharmaceutical packaging materials, medical devices, etc. With global sourcing advantages, the group is fully capable of meeting the one-stop sourcing needs of global customers. Today, Arshine's marketing network has spread over more than 100 countries and regions on five continents, providing professional service for global customers.
Arshine Group has been highly recognized by all sectors of society since its establishment! Arshine is an AA Grade customer of Sinosure in Hunan Province and an AEO-accredited enterprise of China Customs. It has been certified by ISO9001 and EU FAMI-QS, and has obtained Class III Medical Device Trading Permit. As a member of the Board of Directors of the China Chamber of Commerce for Import & Export of Medicines & Health Products, Arshine has been awarded the title of "Quality Supplier and Partner in the International Market" by the Chamber in recent years. As the best human resource management company in Hunan Province, the Group has been awarded as Employer of the Year for several successive years.
In the future, Arshine Group will expand its business in the health industry, increase investment in R&D and production, and gradually become a trading, service and investment integrated group enterprise with trading business as its core. Arshinees will stay true to the mission of serving the global health industry and helping create a win-win situation.
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