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p-Anisidine104-94-9C7H9NO

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CAS No.:

104-94-9

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

上海

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-07-17

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Qingdao Orient Chemical Co.,LTD

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Trader

Location:

China

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Product Description
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Inquiry History

Description

Product Detail

p-Anisidine Basic information

Anisidine value

Product Name:	p-Anisidine
Synonyms:	P-AMINOANISOLE;4-[4-(4-Aminophenyl)phenyl]aniline;p,p'-Diaminoterphenyl;1,4-Anisidine;p-Anisidine,95%,pract.;1-Methoxy-4-amino-benzen (p-anisidin);1-Methoxy-4-amino-benzene / p-anisidine;4-Methoxy-1-aminobenzene
CAS:	104-94-9
MF:	C7H9NO
MW:	123.15
EINECS:	203-254-2
Product Categories:	Thiophenes;amine;Intermediates of Dyes and Pigments;Intermediates;Anilines (Building Blocks for Liquid Crystals);Building Blocks for Liquid Crystals;Functional Materials;104-94-9;bc0001;K00001
Mol File:	104-94-9.mol

p-Anisidine Chemical Properties

Melting point	56-59 °C(lit.)
Boiling point	240-243 °C(lit.)
bulk density	700kg/m3
density	1.06
vapor density	4.28
vapor pressure	0.02 hPa (20 °C)
refractive index	1.5559
Fp	122 °C
storage temp.	Store below +30°C.
solubility	21g/l
pka	5.34(at 25℃)
form	crystalline
color	dark gray to brown
Specific Gravity	1.07
PH	7.7 (1g/l, H2O, 20℃)
Water Solubility	21 g/L (20 ºC)
Merck	14,667
BRN	471556
Henry's Law Constant	(x 10^-8 atmm³/mol): 6.62 at 25 °C (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999)
Exposure limits	ACGIH TLV-TWA:0.5 mg/m3 (0.1 ppm) OSHA PEL-TWA:0.5 mg/m3 NIOSH REL-TWA:0.5 mg/m3;IDLH:50 mg/m3
Dielectric constant	8.8399999999999999
Stability:	Hygroscopic, Material Darkens In Storage With No Loss In Purity
InChI	1S/C7H9NO/c1-9-7-4-2-6(8)3-5-7/h2-5H,8H2,1H3
InChIKey	BHAAPTBBJKJZER-UHFFFAOYSA-N
SMILES	COc1ccc(N)cc1
LogP	0.950
CAS DataBase Reference	104-94-9(CAS DataBase Reference)
IARC	3 (Vol. 27, Sup 7) 1987
NIST Chemistry Reference	Benzenamine, 4-methoxy-(104-94-9)
EPA Substance Registry System	p-Anisidine (104-94-9)

Safety Information

Hazard Codes	T+,N,Xi
Risk Statements	45-26/27/28-33-50
Safety Statements	53-28-36/37-45-61-28A
RIDADR	UN 2811 6.1/PG 3
OEB	C
OEL	TWA: 0.5 mg/m3 [skin]
WGK Germany	2
RTECS	BZ5450000
F	8
Autoignition Temperature	959 °F
TSCA	TSCA listed
HazardClass	6.1
PackingGroup	III
HS Code	29222200
Storage Class	6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
Hazard Classifications	Acute Tox. 1 Dermal Acute Tox. 2 Inhalation Acute Tox. 2 Oral Aquatic Acute 1 Aquatic Chronic 3 Carc. 1B STOT RE 2
Hazardous Substances Data	104-94-9(Hazardous Substances Data)
Toxicity	Acute oral LD₅₀ for rats 1,400 mg/kg, mice 810 mg/kg, rabbits 2,900 mg/kg (quoted, RTECS, 1985).
IDLH	50 mg/m3

MSDS Information

Provider	Language
4-Methoxybenzeneamine	English
SigmaAldrich	English
ACROS	English
ALFA	English

p-Anisidine Usage And Synthesis

Anisidine value	Anisidine value (AV) is a measure of the aldehyde levels in an oil or fat, in particular those that are unsaturated (and principally the 2–alkenals). To determine AV, a solution of the oil or fat in iso-octane is reacted with p-anisidine in glacial acetic acid to form yellowish reaction proucts. The AV is then determined from the absorbance measured at 350 nm, both before and after reaction.
Chemical Properties	Anisidine exists as ortho-, meta-, and paraisomers. They have characteristic amine (fishy) odors. releases toxic nitrogen oxides when heated to decomposition (Sax and Lewis, 1987).
Physical properties	Yellow to light brown powder, leaflets, solid or crystals with a characteristic amine or ammonialike odor. soluble in ethanol and ether, slightly soluble in water.
Uses	p-Anisidine is used mostly for producing dyes, and some smaller quantities are employed in making pharmaceuticals and liquid crystals.
Definition	ChEBI: P-anisidine is a substituted aniline that is aniline in which the hydrogen para to the amino group has been replaced by a methoxy group. It is used as a reagent for the detection of oxidation products such as aldehydes and ketones in fats and oils. It has a role as a reagent and a genotoxin. It is a member of methoxybenzenes, a substituted aniline and a primary amino compound.
Application	p-Anisidine is used as a reagent to indicate the secondary stage of the oxidation, it is one of the three possible isomers of the Anisidine or methoxyaniline. The other two isomers are o-Anisidine (2-methoxyaniline) and m-Anisidine (3-methoxyaniline). The p-anisidine is widely used as an intermediate in the production of numerous azo and triphenylmethane dyes, and pigments. It is also used in the production of pharmaceuticals including the guaiacol expectorant, as an antioxidant for polymercaptan resins, and as a corrosion inhibitor for steel. Apart from the beneficial use of p-anisidine, it is toxic for human beings. The acute exposure may cause skin irritation, whereas the chronic exposure may cause headaches, vertigo, and blood complications like sulfhemoglobin, and methemoglobin. The oral exposure to anisidine hydrochloride resulted in cancer of the urinary bladder in male and female rats. https://www.longdom.org/open-access/physicochemical-and-spectroscopic-characterization-of-biofield-energytreated-panisidine-paco-1000102.pdf
Preparation	p-Anisidine is an important intermediate for synthesis of dye, medicine and perfume. Traditional preparation of p-Anisidine uses iron powder or sodium sulfide as reductant, which produces a large amount of waste and results in serious environment pollution problem. Liquid phase catalytic hydrogenation is not only an environmentally benign technique but also of high yield. Synthesis of p-Anisidine by Hydrogenation with Raney-RuNiC as Catalyst
Synthesis Reference(s)	Journal of the American Chemical Society, 99, p. 98, 1977 DOI: 10.1021/ja00443a018 The Journal of Organic Chemistry, 49, p. 1434, 1984 DOI: 10.1021/jo00182a023 Tetrahedron Letters, 21, p. 2603, 1980 DOI: 10.1016/S0040-4039(00)92816-8
General Description	P-anisidine appears as brown crystals or dark brown solid. Characteristic amine odor. (NTP, 1992)
Air & Water Reactions	Insoluble in water.
Reactivity Profile	p-Anisidine may be sensitive to heat, light and moisture. Reacts with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents. Incompatible with alkaline materials. Incompatible with aldehydes, ketones and nitrates.
Hazard	Strong irritant. Toxic when absorbed through the skin. Questionable carcinogen.
Fire Hazard	p-Anisidine is flammable.
Safety Profile	Moderately toxic by several routes. A mild sensitizer. May cause a contact dermatitis. Mutation data reported. Questionable carcinogen. See also ANILINE. When heated to decomposition it emits toxic fumes of Nox
Potential Exposure	Anisidines are used in the manufacture of azo dyes; pharmaceuticals; textile-processing chemicals Incompatibilities: Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine,bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Attacks some coatings and some forms of plastic and rubber.
Carcinogenicity	Available data were inadequate to evaluate the carcinogenicity of p-anisidine.
Shipping	UN2431 Anisidines, Hazard Class: 6.1; Labels: 6.1-Poisonous materials
Purification Methods	Crystallise p-anisidine from H2O or aqueous EtOH. Dry it in a vacuum oven at 35o for 6hours and store it in a dry box. [More et al. J Am Chem Soc 108 2257 1986.] Purify it also by vacuum sublimation [Guarr et al. J Am Chem Soc 107 5104 1985]. [Beilstein 13 IV 1015.]
Waste Disposal	Dissolve in combustible solvent (alcohols, benzene, etc.) and spray solution into furnace equipped with afterburner and scrubber, or burn spill residue on sand and soda ash absorbent in a furnace.

p-Anisidine Preparation Products And Raw materials

Raw materials

Sodium hydroxide-->Methanol-->Water-->Sodium sulfide-->4-Chloronitrobenzene-->4-Nitroanisole

Preparation Products

beta-Methyl vinyl phosphate (MAP)-->4-Aminopyrimidine-->Disperse Blue 79-->2-Cyano-6-methoxybenzothiazole-->6-Methoxyquinoline-->6-Quinolinol-->2-Amino-6-methoxybenzothiazole-->Azoic Diazo Component 1-->Butylated hydroxyanisole-->5-METHOXYBENZIMIDAZOLE-->5-Methoxy-3-indazolecarboxylic acid-->Basic Blue 54-->2-CARBOMETHOXY-6-METHOXYBENZOTHIAZOLE-->1-(4-Methoxyphenyl)piperazine dihydrochloride-->6-METHOXYBENZOTHIAZOLE-2-CARBOXYLIC ACID-->1-(4-Methoxyphenyl)piperazine-->5-Methoxyisatin-->6-Methoxyquinaldine-->4-METHOXYPHENYLTHIOUREA-->4-CHLORO-2-(4-METHOXY-PHENYLAMINO)-BENZOIC ACID-->cleaner LS-->4-chloro-1'-(4-methoxyphenyl)benzohydrazide-->Methacetin-->2-(4-METHOXYPHENYL)HYDRAZINESULFONIC ACID SODIUM SALT MONOHYDRATE-->VARIAMINE BLUE B DIAZONIUM SALT-->4-METHOXYBENZENEDIAZONIUM TETRAFLUOROBORATE-->Pigment Red 190-->Indometacin-->4-Methoxyphenyl isocyanate-->Catonic Yellow X-8GL-->2-Hydroxy-N-(4-methoxyphenyl)-11H-benzo[a]carbazole-3-carboxamide-->6-METHOXY-4-METHYLQUINOLINE-->Anisonitrile-->6-METHOXY-2-METHYLBENZOTHIAZOLE-->4-Amino-2,5-dichlorophenol-->BASIC YELLOW 28-->3-Hydroxy-4'-methoxy-2-naphthanilide-->Reactive Red Violet X-2R-->4-[(4-methoxyphenyl)amino]benzenediazonium-->Reactive Violet 8

Shop Fluorobenzene462-06-6C6H5F-Detailed Image 2

Basic Info

Product Name:

4-Methoxyaniline

Other Name:

Benzenamine,4-methoxy-;p-Anisidine;4-Methoxybenzenamine;p-Aminoanisole;4-Aminoanisole;p-Methoxyphenylamine;p-Anisylamine;4-Methoxyaniline;p-Anisidine;p-Methoxyaniline;1-Amino-4-methoxybenzene;p-Aminomethoxybenzene;4-Methoxyphenylamine;1,4-Anisidine;4-Aminomethoxybenzene;4-Methoxylaniline;Methyl 4-aminophenyl ether;Anisidine;NSC 7921;4-Methoxy-1-aminobenzene;1619933-04-8

CAS No.:

104-94-9

Molecular Formula:

C7H9NO

InChIKeys:

InChIKey=BHAAPTBBJKJZER-UHFFFAOYSA-N

Molecular Weight:

123.15

Exact Mass:

123.15

BRN:

471556

EC Number:

203-254-2

UNII:

575917SNR4

ICSC Number:

0971

NSC Number:

7921

UN Number:

2431

DSSTox ID:

DTXSID7024532

Color/Form:

White solid|Fused crystalline mass|Crystals, plates from aqueous solution|Yellow to brown, crystalline solid

HScode:

29222200

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

35.2

XLogP3:

0.95

Appearance:

dark gray to brown crystalline

Density:

1.071 g/cm³ @ Temp: 57 °C

Melting Point:

57.2 °C

Boiling Point:

243 °C

Flash Point:

122 °C

Refractive Index:

1.5559

Water Solubility:

H2O: 21 g/L (20 ºC)

Storage Conditions:

2-8°C

Vapor Pressure:

Vapour pressure, Pa at 20°C: 2

Vapor Density:

4.25

Toxicity:

Oral-rat LD50: 1320 mg/kg; Oral-Mouse LD50: 1410 mg/kg

Flammability characteristics:

Open flame is flammable; heat releases toxic aniline, nitrogen oxide gas

Explosive limit:

Finely dispersed particles form explosive mixtures in air.

Odor:

Amine-like odor

Henrys Law Constant:

6.60e-08 atm-m3/mole|Henry's Law constant = 6.60X10-8 atm-cu m/mol at 25 °C

Dissociation Constants:

pKa = 5.36 at 25 °C

Experimental Properties:

Hydroxyl radical reaction rate constant = 9.39X10-11 cu cm/molec-sec at 25 °C (est)

Air and Water Reactions:

Insoluble in water.

Reactive Group:

Ethers

Reactivity Profile:

P-ANISIDINE may be sensitive to heat, light and moisture. Reacts with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents. Incompatible with alkaline materials. Incompatible with aldehydes, ketones and nitrates. (NTP, 1992)

Autoignition Temperature:

515 °C

Ionization Potential:

7.44 eV

Flammable Limits:

Combustible Solid

Physical Dangers:

As a result of flow, agitation, etc., electrostatic charges can be generated. Dust explosion possible if in powder or granular form, mixed with air.

See More 4-Methoxyaniline Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 2, Oral

Acute toxicity - Category 1, Dermal

Acute toxicity - Category 2, Inhalation

Specific target organ toxicity â repeated exposure, Category 2

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H300 Fatal if swallowed H310 Fatal in contact with skin H330 Fatal if inhaled H373 May cause damage to organs through prolonged or repeated exposure H400 Very toxic to aquatic life
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P262 Do not get in eyes, on skin, or on clothing. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P284 [In case of inadequate ventilation] wear respiratory protection. P273 Avoid release to the environment.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P316 Get emergency medical help immediately. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P320 Specific treatment is urgent (see ... on this label). P319 Get medical help if you feel unwell. P391 Collect spillage.
Storage	P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames. Prevent deposition of dust. Closed system, dust explosion-proof electrical equipment and lighting. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Separated from strong oxidants, strong bases, acids, chloroformates and food and feedstuffs. Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access.Store in tightly closed containers in a cool, dark, well-ventilated area. Protect against sunlight and strong oxidizers. Metal containers involving the transfer of this chemical should be grounded and bonded. Where possible, automatically pump liquid from drums or other storage containers to process containers. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only non-sparking tools and equipment, especially when opening and closing containers of this chemical. Sources of ignition, such as smoking and open flames, are prohibited where this chemical is used, handled, or stored in a manner that could create a potential fire or explosion hazard. A regulated, marked area should be established where this chemical is handled, used, or stored ... Anisidines

See More 4-Methoxyaniline Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

10 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	p-Anisidine	500.00 KG	Oct 9, 2023
India	PARA ANSIDINE	5000.00 KG	Aug 29, 2023
India	P-ANISIDINE	4 MT	Aug 26, 2024
India	Para Anisidine 3,6 Di Sulfonic Acid (PA 3 6 DSA)	1.00 KG	Jul 3, 2023
Russia	p-Anisidine	1 MT	Jun 26, 2023
Philippines	p-anisidine	100 G	Feb 25, 2026
India	Para Anisidine	25.00 MT	Sep 28, 2023
India	N,N-DIMETHYL CARBAMOYL CHLORIDE	5000.00 KG	Aug 29, 2023
India	ETHYL FORMATE	8000.00 KG	Aug 29, 2023
India	RESORCINOL	5000.00 KG	Aug 29, 2023

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