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Phthalic anhydride85-44-9

Name: Phthalic anhydride85-44-9
Brand: OORENT
SKU: pr2606171662
Price: 33 USD
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CAS No.:

85-44-9

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

上海

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-07-17

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Description

Product Detail

Phthalic anhydride Basic information

Product Name:	Phthalic anhydride
Synonyms:	AKOS BBS-00004337;2-Benzofuran-1,3-dione;Anhydrid kyseliny ftalove;Anhydride phtalique;anhydridephtalique;anhydridephtalique(etatvitreux);anhydridephtalique(french);1,2-Benzenedicarboxylic Anhydride
CAS:	85-44-9
MF:	C8H4O3
MW:	148.12
EINECS:	201-607-5
Product Categories:	Building Blocks;Carbonyl Compounds;pharmacetical;Carboxylic Acid Anhydrides;Chemical Synthesis;Organic Building Blocks;ACS GradeOrganic Building Blocks;Carbonyl Compounds;Carboxylic Acid Anhydrides;Essential Chemicals;Routine Reagents;Organic Building Blocks;85-44-9
Mol File:	85-44-9.mol

Phthalic anhydride Chemical Properties

Melting point	131-134 °C(lit.)
Boiling point	284 °C(lit.)
bulk density	500-700kg/m3
density	1,53 g/cm³
vapor density	5.1 (vs air)
vapor pressure	<0.01 mm Hg ( 20 °C)
refractive index	1.4500 (estimate)
Fp	152 °C
storage temp.	Store below +30°C.
solubility	6g/l (slow decomposition)
form	Flaky Crystals
pka	2.97[at 20 ℃]
color	White
Odor	Characteristic choking odor
PH	2 (6g/l, H2O, 20℃)
PH Range	2 at 6 g/l at 20 °C
explosive limit	1.7-10.5%(V)
Water Solubility	6 g/L (20 ºC)
Sensitive	Moisture Sensitive
Merck	14,7372
BRN	118515
Henry's Law Constant	6.29 at 20 °C (approximate - calculated from water solubility and vapor pressure)
Exposure limits	ACGIH:TLV-TWA 0.002 mg/m3 (0.0003 ppm),Inhalable fraction and vapor; TLV-STEL 0.005 mg/m3 (0.0009 ppm),Inhalable fraction and vapor OSHA:PEL-TWA 2 ppm (12 mg/m3) NIOSH:REL-TWA 6 mg/m3
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, moisture, strong acids. Dust may form an explosive mixture with air.
Cosmetics Ingredients Functions	NOT REPORTED
InChI	1S/C8H4O3/c9-7-5-3-1-2-4-6(5)8(10)11-7/h1-4H
InChIKey	LGRFSURHDFAFJT-UHFFFAOYSA-N
SMILES	O=C1OC(=O)c2ccccc12
LogP	2.07 at 20℃
CAS DataBase Reference	85-44-9(CAS DataBase Reference)
NIST Chemistry Reference	Phthalic anhydride(85-44-9)
EPA Substance Registry System	Phthalic anhydride (85-44-9)

Safety Information

Hazard Codes	Xn
Risk Statements	22-37/38-41-42/43
Safety Statements	23-24/25-26-37/39-46-22
RIDADR	UN 2214 (PHTHALIC ANHYDRIDE with more than 0.05 % of maleic anhydride)
OEB	B
OEL	TWA: 6 mg/m3 (1 ppm)
WGK Germany	1
RTECS	TI3150000
F	10-21
Autoignition Temperature	580 °C
TSCA	TSCA listed
HazardClass	8
PackingGroup	III
HS Code	29173500
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Dam. 1 Resp. Sens. 1 Skin Irrit. 2 Skin Sens. 1 STOT SE 3
Hazardous Substances Data	85-44-9(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: 1530 mg/kg LD50 dermal Rabbit > 3160 mg/kg
IDLH	60 mg/m3

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

Phthalic anhydride Usage And Synthesis

Description	Phthalic anhydride is the organic compound with the formula C6H4(CO)2O. It is the anhydride of phthalic acid. This colourless solid is an important industrial chemical, especially for the large-scale production of plasticizers for plastics. Phthalic anhydride is an important chemical intermediate in the plastics industry from which are derived numerous phthalate esters that function as plasticizers in synthetic resins. Phthalic anhydride itself is used as a monomer for synthetic resins such as glyptal, the alkyd resins, and the polyester resins. Phthalic anhydride is also used as a precursor of anthraquinone, phthalein, rhodamine, phthalocyanine, fluorescein, and xanthene dyes. Phthalic anhydride is used in the synthesis of primary amines, the agricultural fungicide phaltan, and thalidomide. Other reactions with phthalic anhydride yield phenolphthalein, benzoic acid, phthalylsulfathiazole (an intestinal antimicrobial agent), and orthophthalic acid.
Chemical Properties	Phthalic Anhydride is moderately flammable, white solid (flake) or a clear, colorless, mobile liquid (molten) Characteristic, acrid, choking odor. It is very slightly soluble in H2O, soluble in alcohol, and slightly soluble in ether.
Physical properties	Colorless to pale cream crystals with a characteristic, choking odor. Moisture sensitive. Odor threshold concentration is 53 ppb (quoted, Amoore and Hautala, 1983).
Uses	Phthalic anhydride is used in the manufacture of unsaturated polyesters and as a curing agent for epoxy resins. When used as a pigment, it can be responsible for sensitization in ceramic workers.
Definition	ChEBI: Phthalic anhydride is the cyclic dicarboxylic anhydride that is the anhydride of phthalic acid. It has a role as an allergen. It is a cyclic dicarboxylic anhydride and a member of 2-benzofurans.
Preparation	The most important modifying component used in the manufacture of linear unsaturated polyesters is phthalic anhydride. The anhydride is generally obtained by the oxidation of o-xylene: The reaction is carried out in the vapour phase by passing a mixture of o-xylene and air over a catalyst such as vanadium pentoxide supported on silica and promoted with titanium dioxide at about 400C. The exit gases are cooled and the phthalic anhydride is collected and purified by distillation under reduced pressure.
Synthesis Reference(s)	The Journal of Organic Chemistry, 25, p. 616, 1960 DOI: 10.1021/jo01074a035 Synthesis, p. 612, 1973 Tetrahedron Letters, 20, p. 2301, 1979 DOI: 10.1016/S0040-4039(01)93957-7
General Description	A colorless to white lustrous solid in the form of needles with a mild distinctive odor. Moderately toxic by inhalation or ingestion and a skin irritant. Melting point 64°F Flash point 305°F. Forms a corrosive solution when mixed with water. Used in the manufacture of materials such as artificial resins.
Air & Water Reactions	Reacts, usually slowly with water to form phthalic acid and heat [Merck 11th ed. 1989]. The phthalic acid is somewhat soluble in water.
Reactivity Profile	Phthalic anhydride reacts exothermically with water. The reactions are sometimes slow, but can become violent when local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases. Undergoes exothmeric nitration with fuming nitric acid-sulfuric acid and may give mixtures of the potentially explosive phthaloyl nitrates or nitrites or their nitro derivatives [Chem. & Ind. 20:790. 1972]. Phthalic anhydride reacts violently with CuO at elevated temperatures [Park, Chang-Man, Richard J. Sheehan. hthalic Acids and Other Benzenepolycarboxylic Acids Kirk-Othmer Encyclopedia of Chemical Technology. John Wiley & Sons, Inc. 2005]. Mixtures of Phthalic anhydride and anhydrous CO2 explode violently if heated [eaflet No. 5, Inst. of Chem., London, 1940].
Health Hazard	Solid irritates skin and eyes, causing coughing and sneezing. Liquid causes severe thermal burns.
Fire Hazard	Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
Pharmaceutical Applications	Phthalic anhydride reacted with cellulose acetate forms cellulose acetate phthalate (CAP), a common enteric coating excipient that has also been shown to have antiviral activity. Phthalic anhydride is a degradation product of CAP.
Contact allergens	Phthalic anhydride is used in the manufacture of unsaturated polyesters and as a curing agent for epoxy resins. When used as a pigment, it can be responsible for sensitization in ceramic workers. Phthalic anhydride per se is not responsible for the sensitization to the resin used in nail varnishes phthalic anhydride/trimellitic anhydride/ glycols copolymer.
Safety Profile	Poison by ingestion. Experimental teratogenic effects. A corrosive eye, skin , and mucous membrane irritant. A common air contaminant. Combustible when exposed to heat or flame; can react with oxidzing materials. Moderate explosion hazard in the form of dust when exposed to flame. The production of ths material has caused many industrial explosions. Mixtures with copper oxide or sodium nitrite explode when heated. Violent reaction with nitric acid + sulfuric acid above 80℃. To fight fire, use CO2, dry chemical. Used in plasticizers, polyester resins, and alkyd resins, dyes, and drugs. See also ANHYDRIDES.
Synthesis	Phthalic anhydride is a precursor to a variety of reagents useful in organic synthesis. Important derivatives include phthalimide and its many derivatives. Chiral alcohols form half-esters (see above), and these derivatives are often resolvable because they form diastereomeric salts with chiral amines such as brucine. A related ring - opening reaction involves peroxides to give the useful peroxy acid: C₆H₄(CO)₂O + H₂O₂ → C₆H₄(CO₃H)CO₂H.
Potential Exposure	Phthalic anhydride is used in plasticizers; in the manufacture of phthaleins; benzoic acid; alkyd and polyester resins; synthetic indigo; and phthalic acid;which is used as a plasticizer for vinyl resins. To a lesser extent, it is used in the production of alizarin, dye, anthranilic acid; anthraquinone, diethyl phthalate; dimethyl phthalate; erythrosine, isophthalic acid; methylaniline, phenolphthalein, phthalamide, sulfathalidine, and terephthalic acid. It has also found uses as a pesticide intermediate.
Shipping	UN2214 Phthalic anhydride with＞.05 % maleic anhydride, Hazard class: 8; Labels: 8-Corrosive material.
Purification Methods	Distil the anhydride under reduced pressure. Purify it from the acid by extracting with hot CHCl3, filtering and evaporating. The residue is crystallised from CHCl3, CCl4 or *benzene, or sublimed. Fractionally crystallise it from its melt. Dry it under vacuum at 100o. [Saltiel J Am Chem Soc 108 2674 1986, Beilstein 17/11 V 253.]
Toxicity evaluation	Phthalic anhydride modulates lipid mediator release and cytokine formation and has sensitizing effects on the respiratory tract. The local irritating effect particularly on the mucous membranes probably depends on the hydrolysis to phthalic acid.
Incompatibilities	Dust forms an explosive mixture with air. Phthalic anhydride reacts exothermically with water. The reactions are sometimes slow, but can become violent when local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases. Converted to phthalic acid in hot water. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. caustics, ammonia, amines, water. Reacts violently with copper oxide or sodium nitrite 1 heat.
Toxics Screening Level	The initial threshold screening level (ITSL) for phthalic anhydride (CAS # 85-44-9) is 20 μg/m 3 with an annual averaging time.
Waste Disposal	Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

Phthalic anhydride Preparation Products And Raw materials

Raw materials

Benzene-->Maleic anhydride-->Naphthalene-->o-Xylene-->Vanadium(V) oxide-->Motor benzol-->Lubricating oil-->Technical naphthalene-->Storage sump

Preparation Products

2,3,4,5-Tetrafluorobenzoic acid-->2-Methyl anthraquinone-->2-Bibenzylcarboxylic acid-->2-Benzoylbenzoic acid-->DIPHENYL PHTHALATE-->1,2,5-OXADIAZOLE-3-CARBOXYLIC ACID-->CYCLOOCTENE-->Fluorescein-->Dioctyl phthalate-->Dicapryl Phthalate-->3-METHYL-1,2,5-OXADIAZOLE-->Amino resin varnish-->Indobufen-->Folpet-->Didecyl phthalate-->2',7'-dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one-->Diallyl phthalate-->Alkyd resin insulating paint-->N-(Hydroxymethyl)phthalimide-->2-(MORPHOLINE-4-CARBONYL)-BENZOIC ACID-->N-(2-Bromoethyl)phthalimide-->2,3-DIHYDRO-2-PHENYL-1H-ISOINDOL-1-OXO-ISOINDOLINE-->DI-ISO-DECYL PHTHALATE-->Diisobutyl phthalate-->2-Ethylanthraquinone-->2-Chloroanthraquinone-->5-(2-Carboxybenzoyl)-2-chlorobenzenesulfonyl chloride-->DI-N-PENTYL PHTHALATE-D4-->Dicyclohexyl phthalate-->BENZALPHTHALIDE-->C.I. 564100-->2-BENZOYLBENZOYL CHLORIDE-->N-PHENYLPHTHALIMIDE-->Diisononyl phthalate-->1-CHLORO-4-METHOXYPHTHALAZINE-->Potassium hydrogen phthalate-->N-PHTHALOYL-DL-GLUTAMIC ANHYDRIDE-->Solvent Red 49-->Dinonyl phthalate-->Diisooctyl phthalate

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Basic Info

Product Name:

Phthalic anhydride

Other Name:

1,3-Isobenzofurandione;Phthalic anhydride;ESEN;Phthalandione;1,3-Phthalandione;Phthalic acid anhydride;Retarder AK;Retarder ESEN;Retarder PD;1,2-Benzenedicarboxylic anhydride;Vulkalent B/C;TGL 6525;Araldite HT 901;HT 901;Phthalanhydride;Sconoc 7;Retarder B-C;NSC 10431;Sconoc 5;2-Benzofuran-1,3-dione;Rikacid PA;OP 392;ADP 1200;1,3-Dihydro-2-benzofuran-1,3-dione;39363-63-8

CAS No.:

85-44-9

Molecular Formula:

C8H4O3

InChIKeys:

InChIKey=LGRFSURHDFAFJT-UHFFFAOYSA-N

Molecular Weight:

148.116

Exact Mass:

148.016

HScode:

2917350000

Categories:

Alcohols, Phenols, Phenol Alcohols

Characteristics

PSA:

43.37

XLogP3:

0.9972

Appearance:

white crystalline solid with choking odour

Density:

1.53

Melting Point:

129-132ºC

Boiling Point:

284ºC

Flash Point:

152ºC

Refractive Index:

1.646

Water Solubility:

6 g/L (20 ºC)

Storage Conditions:

Store at RT.

Vapor Pressure:

<0.01 mm Hg ( 20 °C)

Vapor Density:

5.1 (vs air)

See More Phthalic anhydride Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Skin irritation, Category 2

Serious eye damage, Category 1

Skin sensitization, Category 1

Specific target organ toxicity â single exposure, Category 3

Respiratory sensitization, Category 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H302 Harmful if swallowed H315 Causes skin irritation H318 Causes serious eye damage H317 May cause an allergic skin reaction H335 May cause respiratory irritation H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P271 Use only outdoors or in a well-ventilated area. P284 [In case of inadequate ventilation] wear respiratory protection.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P317 Get medical help. P333+P317 If skin irritation or rash occurs: Get medical help. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell. P342+P316 If experiencing respiratory symptoms: Get emergency medical help immediately.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Separated from combustible substances, reducing agents, strong oxidants, strong bases, strong acids and food and feedstuffs. See Chemical Dangers. Ventilation along the floor. Dry. Well closed.Chemical stability: Stable under recommended storage conditions.

See More Phthalic anhydride Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

124 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Factory Supply Phthalic Anhydride/PA 99.9% CAS: 85-44-9	25 MT	Oct 27, 2023
India	Phthalic Anhydride	26 MT	Aug 29, 2024
Germany	Phthalic Anhydride	230 TON	Jul 22, 2024
Ireland	Phthalic Anhydride	20 TON	Apr 25, 2025
India	Phthalic Anhydride	20.00 MT	Feb 18, 2024
Qatar	Phthalic Anhydride	60.00 TON	May 23, 2024
United Kingdom	Phthalic Anhydride	100 MT	May 21, 2026
India	Phthalic Anhydride	600 MT	Dec 17, 2025
Saudi Arabia	Phthalic Anhydride	1.00 KG	Nov 4, 2025
South Korea	Phthalic anhydride	1 40' Fcl	Apr 30, 2025
United States	Phthalic Anhydride	100 MT	Apr 14, 2025
Zambia	Phthalic Anhydride (PA)	1 MT	Mar 31, 2025
Kuwait	phthalic anhydride	20.00 MT	Feb 20, 2025
Argentina	Anhídrido Ftálico (PA)	1 MT	Jan 29, 2025
Egypt	Phthalic Anhydride	1000.00 KG	Jan 24, 2025
Pakistan	Phthalic Anhydride	1 MT	Dec 17, 2024
Egypt	Phthalic Anhydrate	2 20' Fcl	Dec 4, 2024
Germany	pthalic anhydride	200 TON	Aug 21, 2024
United States	Phthalic anhydride	300000 KG	Jul 19, 2024
India	Phthalic anhydride	20.00 TON	Jul 10, 2024

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Phthalic anhydride85-44-9

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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