 Home > Organic Chemistry > Carboxylic Acids and Derivatives > Ethyl cyanoacetate for Sale > Ethyl cyanoacetate105-56-6C5H7NO2

Ethyl cyanoacetate105-56-6C5H7NO2 buy - large image1

Ethyl cyanoacetate105-56-6C5H7NO2 buy - image1

Ethyl cyanoacetate105-56-6C5H7NO2 buy - image2

Ethyl cyanoacetate105-56-6C5H7NO2 buy - image3

Ethyl cyanoacetate105-56-6C5H7NO2 buy - image4

Ethyl cyanoacetate105-56-6C5H7NO2

1 Inquiries

Unit Price:

$33-34/MT FOB

Get Latest Price 

CAS No.:

105-56-6

Grade:

Industrial Grade

Content:

99.5%

Port:

上海

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-07-17

Contact Supplier

 Chat Now

Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

 Visit Store

Product Description
Seller Information
Inquiry History

Description

Product Detail

Ethyl cyanoacetate Basic information

Product Name:	Ethyl cyanoacetate
Synonyms:	2-cyano-aceticacidethylester;Acetic acid,2-cyano-, ethyl ester;Aceticacid,cyano-,ethylester;Cyanacetate ethyle;cyanacetateethyle;ethylcyanacetate;Ethylcyanoacetat;Ethylester kyseliny kyanoctove
CAS:	105-56-6
MF:	C5H7NO2
MW:	113.11
EINECS:	203-309-0
Product Categories:	C2 to C5;Carbonyl Compounds;Esters;Alpha Sort;Chemical Class;E;Pharmaceutical Intermediates;E-LAlphabetic;EQ - EZAnalytical Standards;EstersAnalytical Standards;Nitriles;Volatiles/ Semivolatiles;organic chemical;Halogenated Heterocycles;1
Mol File:	105-56-6.mol

Ethyl cyanoacetate Chemical Properties

Melting point	-22 °C (lit.)
Boiling point	208-210 °C (lit.)
density	1.063 g/mL at 25 °C (lit.)
vapor density	3.9 (vs air)
vapor pressure	1 mm Hg ( 67.8 °C)
refractive index	n20/D 1.418(lit.)
Fp	>230 °F
storage temp.	Store below +30°C.
solubility	20g/l
pka	3.19±0.10(Predicted)
form	Liquid
color	Clear
Water Solubility	20 g/L (20 ºC)
Merck	14,3786
BRN	605871
Henry's Law Constant	3.4×10¹ mol/(m³Pa) at 25℃, Duchowicz et al. (2020)
Dielectric constant	26.9（20℃）
InChI	1S/C5H7NO2/c1-2-8-5(7)3-4-6/h2-3H2,1H3
InChIKey	ZIUSEGSNTOUIPT-UHFFFAOYSA-N
SMILES	CCOC(=O)CC#N
LogP	-0.119-1.05 at 23-25℃ and pH6.1
Surface tension	70.2mN/m at 1.034g/L and 23℃
CAS DataBase Reference	105-56-6(CAS DataBase Reference)
NIST Chemistry Reference	Acetic acid, cyano-, ethyl ester(105-56-6)
EPA Substance Registry System	Ethyl cyanoacetate (105-56-6)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	20/21/22-36/38
Safety Statements	36/37-37/39-26
RIDADR	3276
WGK Germany	1
RTECS	AG4110000
F	10
Autoignition Temperature	460 °C
TSCA	TSCA listed
HS Code	2926 90 70
Storage Class	10 - Combustible liquids
Hazard Classifications	Eye Irrit. 2
Hazardous Substances Data	105-56-6(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: > 2000 mg/kg

MSDS Information

Provider	Language
Ethyl 2-cyanoacetate	English
SigmaAldrich	English
ACROS	English
ALFA	English

Ethyl cyanoacetate Usage And Synthesis

Description	Ethyl cyanoacetate is the ethyl ester of cyanoacetic acid. Ethyl cyanoacetate hydrolizes rapidly under neutral and alkaline conditions to cyanoacetic acid and ethanol (and so it does under most physiological and environmental conditions), while in acid pH the half life is considerably longer. Knoevenagel condensation of ethyl cyanoacetate with aldehyde is reported. Microwave enhanced Knoevenegal condensation reaction of ethyl cyanoacetate with an aldehyde, P2O5, piperidine and chlorobenzene is reported.
Chemical Properties	Ethyl cyanoacetate is a colorless to straw colored liquid with a mild pleasant odor
Uses	Ethyl cyanoacetate may be used in the synthesis of ethyl glyoxylate. It was used to investigate the Knoevenagel condensation reactions in microreactor using zeolite catalysts obtained by grafting amino groups onto NaX and CsNaX zeolites.
Uses	Reagent used in labelled pyrimidine and purine synthesis. Ethyl cyanoacetate is an ester. It may be used in the synthesis of ethyl glyoxylate.It was used to investigate the Knoevenagel condensation reactions in microreactor using zeolite catalysts obtained by grafting amino groups onto NaX and CsNaX zeolites.
Preparation	Ethyl cyanoacetate can be prepared by the action of sodium or potassium cyanide on ethyl chloroacetate, and by the action of sodium cyanide on sodium chloroacetate, followed by esterification.
General Description	A colorless liquid. Denser than water. Contact may irritate skin, eyes and mucous membranes. Flash point 210°F. May be toxic by ingestion. Used to make other chemicals.
Air & Water Reactions	Slightly soluble in water.
Reactivity Profile	Ethyl cyanoacetate is both a nitrile and an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.
Hazard	Toxic by ingestion and inhalation.
Health Hazard	TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard	Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
Safety Profile	oison by ingestion. Moderately toxic by intraperitoneal and subcutaneous routes. Combustible when exposed to heat or flame; can react with oxidzing materials. Wdl react with water or steam to produce toxic and flammable vapors. To fight fire, use CO2, dry chemical. When heated to decomposition or on contact with acid or acid fumes it emits highly toxic fumes of CN-. See also NITRILES.
Potential Exposure	A nitrile used to manufacture dyes, pharmaceuticals, and other chemicals.
First aid	If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit
storage	re poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area away from oxidizers, strong bases, strongacids, reducing agents, moisture, and sources of ignition.Where possible, automatically pump liquid from drums orother storage containers to process containers
Shipping	UN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5).
Purification Methods	Shake the ester several times with aqueous 10% Na2CO3, wash it well with water, dry with Na2SO4 and fractionally distil it. [Beilstein 2 IV 1889.]
Incompatibilities	Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, and reducing agents. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids. Reacts with moisture, water, and steam, forming toxic fumes.
Toxics Screening Level	The ITSL for ethyl cyanoacetate has been changed from 0.04 μg/m3 to 0.1 μg/m3 based on an annual averaging time.
Waste Disposal	Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
References	[1] Wohlfarth, C. “Viscosity of ethyl cyanoacetate.” 1900. 0.、 [2] A. C. Cope, E. M. Hancock. “Ethyl (1‐Ethylpropylidene)cyanoacetate.” Organic Syntheses 38 1 (2003): 46–46. [3] Ismailov, V.M. et al. “SYNTHESIS BASED ON ETHYL CYANOACETATE.” Kimya problemlri 86 1 (2023): 0. [4] T.R. Kasturi, A. Srinivasan. “A revised structure for the condensation product of 2-carbethoxycyclopentanone and ethyl cyanoacetate.” Tetrahedron 22 8 (1966): Pages 2575-2580. [5] Akram Ranjbar Derranji, Mohammad Anary-Abbasinejad. “An efficient synthesis of 4,5-disubstituted 1,2,3-triazoles by three-component reaction between sodium azide, ethyl cyanoacetate or malonitrile and arylglyoxals.” Synthetic Communications 54 6 (2024): Pages 471-477.

Ethyl cyanoacetate Preparation Products And Raw materials

Raw materials

Ethanol-->Hydrochloric acid-->Sulfuric acid-->Sodium cyanide-->Chloroacetic acid-->Ethyl chloroacetate-->Sodium chloroacetate-->Cyanoacetic acid

Preparation Products

Ethyl 4-amino-2-(ethylthio)-5-pyrimidinecarboxylate-->2-AMINO-5-ISOPROPYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER-->2-AMINO-4-ETHYL-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER-->Dacarbazine-->Triamterene-->2-AMINO-4,6-DIMETHYL-3-PYRIDINECARBOXAMIDE-->Allopurinol-->5-AMINO-4-CYANO-3-METHYL-THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER-->6-AMINO-2-MERCAPTO-PYRIMIDIN-4-OL-->3-AMINO-2,2-DIMETHYL-1-PROPANOL-->ETHYL 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXYLATE-->1-Cyclohexyl-1,2,3,4-tetrahydro-2,4-dioxopyrimidine-5-carbonitrile ,97%-->6-AMINO-3-METHYLURACIL-->2-AMINO-6-METHYL-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER-->1,2,3,5-TETRAHYDRO-8-THIA-5,7-DIAZA-CYCLOPENTA[A]INDENE-4-ONE-->5,6-Diamino-1-methyluracil-->6-AMINO-2-METHYLTHIO-3-METHYLURACIL-->5-CYANO-6-HYDROXY-4-METHOXYMETHYL-2-METHYLPYRIDINE-->GUANINE SULFATE-->6-AMINO-1-METHYL-5-NITROSOURACIL-->6-CHLORO-5-CYANO-4-METHOXYMETHYL-3-NITRO-2-PICOLINE-->Ethyl α-cyanoacrylate instantaneous adhesive-->2-CHLORO-4-METHYLQUINOLINE-3-CARBONITRILE-->ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE-->6-Amino-1-methyluracil-->2-Amino-4-trifluoromethylbenzonitrile-->ETHYL 5-AMINO-1-PYRIDIN-2-YL-1H-PYRAZOLE-4-CARBOXYLATE-->2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER-->2-(4,6-diamino-1,3,5-triazin-2-yl)acetic acid-->5-AMINO-3-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER-->1-ETHYL-1-METHYLSUCCINIC ACID-->6-Aminouracil-->Disperse Yellow S-3GL-->Amiloride hydrochloride-->ETHYL 2-CYANO-3-METHYL-2-PENTENOATE-->ETHYL(Z)-2-CYANO-3-ETHOXY-2-PROPENOATE-->4-Amino-6-hydroxy-2-mercaptopyrimidine monohydrate

Shop 3-Chloro-1-propene107-05-1-Detailed Image 2

Basic Info

Product Name:

Ethyl cyanoacetate

Other Name:

Acetic acid,2-cyano-,ethyl ester;Acetic acid,cyano-,ethyl ester;Cyanoacetic acid ethyl ester;Cyanoacetic ester;Ethyl cyanoacetate;Ethyl cyanoethanoate;Malonic acid ethyl ester nitrile;Ethyl cyanacetate;Ethyl 2-cyanoacetate;Ethyl α-cyanoacetate;NSC 8844;(Ethoxycarbonyl)acetonitrile;3-Ethoxy-3-oxopropanenitrile;2-Cyanoacetic acid ethyl ester;1427280-50-9

CAS No.:

105-56-6

Molecular Formula:

C5H7NO2

InChIKeys:

InChIKey=ZIUSEGSNTOUIPT-UHFFFAOYSA-N

Molecular Weight:

113.11

Exact Mass:

113.11

BRN:

605871

EC Number:

203-309-0

UNII:

X9N006U0F8

NSC Number:

8844

UN Number:

3276|2666

DSSTox ID:

DTXSID9026718

Color/Form:

Colorless liquid|Colorless to pale straw-colored liquid

HScode:

2926 90 70

Categories:

Carboxylic Acids and Derivatives

Characteristics

PSA:

50.1

XLogP3:

0.06

Appearance:

Clear Liquid

Density:

1.0560 g/cm³ @ Temp: 25 °C

Melting Point:

-22 °C

Boiling Point:

206.0 °C @ Press: 760 Torr

Flash Point:

>230 °F

Refractive Index:

n 20/D 1.418(lit.)

Water Solubility:

H2O: 20 g/L (20 ºC)

Storage Conditions:

Store below +30°C.

Vapor Pressure:

1 mm Hg ( 67.8 °C)

Vapor Density:

3.9 (vs air)

Toxicity:

Oral-rat LDL0: 400 mg/kg

Flammability characteristics:

Open flame is flammable; emits toxic cyanide gas when exposed to heat or acid; emits toxic and flammable gas when exposed to water

Odor:

Slight, pleasant odor

Henrys Law Constant:

Henry's Law constant = 2.89X10-7 atm-cu m/mol at 25 °C (est)

Experimental Properties:

Specific gravity: 1.0560 at 25 °C/4 °C; 1.0306 at 50 °C/4 °C; 1.0110 at 70 °C/|Hydroxyl radical reaction rate constant = 1.72X10-12 cu cm/molecule-sec at 25 °C (est)

Air and Water Reactions:

Slightly soluble in water.

Reactive Group:

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

Reactivity Profile:

ETHYL CYANOACETATE is both a nitrile and an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.

See More Ethyl cyanoacetate Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Acute toxicity - Category 4, Dermal

Acute toxicity - Category 4, Inhalation

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H312 Harmful in contact with skin H332 Harmful if inhaled
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P317 Get medical help. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Ethyl cyanoacetate Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	ethyl cyano acetate	1000 KG	Jan 7, 2026

Post an enquiry for this product

More Choices Find All Products for Sale 

Product Name	Grade / Content	Supplier Name	Details
High Quality 99% Purity of Ethyl cyanoacetate CAS NO 105-56-6 ISO 9001:2005 REACH Verified Producer	Industrial Grade/99	Shaanxi Dideu Medichem Co. Ltd	Inquiry
Ethyl cyanoacetate Cas:105-56-6 organic chemical Factory Supply 99% High Quality	Industrial Grade/99	NANTONG REFORM PETRO-CHEMICAL CO.,LTD	Inquiry
Ethyl cyanoacetate105-56-6	Industrial Grade/99	Shandong Ranhang Biotechnology Co., Ltd.	Inquiry

Ethyl cyanoacetate105-56-6C5H7NO2

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

Related Products

More Choices Find All Products for Sale 

Ethyl cyanoacetate Market Price

Related Searches

Hot Related Products