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Ethyl trifluoroacetate383-63-1

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Unit Price:

$33-34/MT FOB

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CAS No.:

383-63-1

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

上海

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-07-17

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Detail

Ethyl trifluoroacetate Basic information

Product Name:	Ethyl trifluoroacetate
Synonyms:	RARECHEM AL BI 0416;ETHYL 2,2,2-TRIFLUOROACETATE;ETHYL TRIFLUOROACETATE;TIMTEC-BB SBB008466;TRIFLUOROACETIC ACID ETHYL ESTER;Threetrifluoroacetic acid ethyl ester;cb1020;fd06h11
CAS:	383-63-1
MF:	C4H5F3O2
MW:	142.08
EINECS:	206-851-6
Product Categories:	top;organofluorine compounds;Building Blocks;C2 to C5;Carbonyl Compounds;Chemical Synthesis;Fluoro-Aliphatics;Acetics acid and esters;Organic Fluorides;Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Synthetic Organic Chemistry;Esters;Organic Building Blocks;Pharmaceutical intermediates;383-63-1;bc0001;K00001
Mol File:	383-63-1.mol

Ethyl trifluoroacetate Chemical Properties

Melting point	-78 °C
Boiling point	60-62 °C(lit.)
density	1.194 g/mL at 25 °C(lit.)
vapor pressure	18.5kPa at 20℃
refractive index	n20/D 1.307(lit.)
Fp	30 °F
storage temp.	2-8°C
solubility	4g/l
pka	0.43[at 20 ℃]
form	Liquid
color	Clear
Specific Gravity	1.194
PH	4 (4g/l, H2O, 20℃)
Water Solubility	HYDROLYSIS
Sensitive	Moisture Sensitive
BRN	1761411
Henry's Law Constant	8.9×10^-4 mol/(m³Pa) at 25℃, Burkholder et al. (2019)
Stability:	Hygroscopic, Moisture Sensitive, Volatile
InChI	1S/C4H5F3O2/c1-2-9-3(8)4(5,6)7/h2H2,1H3
InChIKey	STSCVKRWJPWALQ-UHFFFAOYSA-N
SMILES	CCOC(=O)C(F)(F)F
LogP	0.79-1.032 at 25℃
CAS DataBase Reference	383-63-1(CAS DataBase Reference)
NIST Chemistry Reference	Acetic acid, trifluoro-, ethyl ester(383-63-1)
EPA Substance Registry System	Ethyl trifluoroacetate (383-63-1)

Safety Information

Hazard Codes	F,Xn,C
Risk Statements	11-22-37/38-41-34
Safety Statements	9-16-26-36/39-45-36/37/39
RIDADR	UN 1993 3/PG 2
WGK Germany	1
Hazard Note	Flammable/Corrosive
TSCA	TSCA listed
HazardClass	3
PackingGroup	II
HS Code	29159080
Storage Class	3 - Flammable liquids
Hazard Classifications	Acute Tox. 4 Oral Eye Dam. 1 Flam. Liq. 2 Skin Irrit. 2 STOT SE 3

MSDS Information

Provider	Language
Ethyl trifluoroacetate	English
SigmaAldrich	English
ACROS	English
ALFA	English

Ethyl trifluoroacetate Usage And Synthesis

Chemical Properties	Colorless to yellow liquid
Uses	Widely used in the synthetic process of medicine, pesticides and organic intermediate.
Uses	Ethyl Trifluoroacetate is an intermediate used in the synthesis of various pharmaceutically active molecules and agricultural products. Ethyl Trifluoroacetate is also useful for the preparation of tri fluoroacylated compounds.
Uses	Ethyl trifluoroacetate is used as an intermediate in organic synthesis to prepare organic fluorine compounds like 3-ethyl-1-methylimidazolium trifluoroacetate (EMITA). It is involved in the syntheses of various pharmaceutically active molecules and agricultural products. It is also useful for the preparation of tri fluoroacylated compounds.
Definition	ChEBI: TRIFLUOROACETIC ACID ETHYL ESTER is an organohalogen compound. It is functionally related to a carboxylic acid.
Preparation	Trifluoroacetic acid and ethanol were used as starting materials with strong-acid cation exchange resin as catalysts at 40 ~ 50 she℃. Add ethanol drop and temperature rising reflux divides the mixture of water and ethanol. After that, collect the mix of thick product ethanol and Ethyl trifluoroacetate. The crude product collected is added a small amount of water, and layering can obtain a content of more than 99.5%. The qualified product Ethyl trifluoroacetate, whose moisture is less than 0.1%, yields more than 95%.
Synthesis Reference(s)	Journal of the American Chemical Society, 72, p. 3527, 1950 DOI: 10.1021/ja01164a056
Flammability and Explosibility	Highly flammable
Purification Methods	Fractionate it through a long Vigreux column (p 11). IR has max at 1800 (CO2) and 1000 (OCO) cm-1 [Fuson et al. J Chem Phys 20 1627 1952, Bergman J Org Chem 23 476 1958]. [Beilstein 2 IV 463.]

Ethyl trifluoroacetate Preparation Products And Raw materials

Raw materials

Trifluoroacetic acid-->Ethyl trifluoromethanesulfonate

Preparation Products

6,7-DIMETHOXY-3-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE-->HEXAFLUOROACETYLACETONE-->METHYL5,5,5-TRIFLUORO-4-OXOPENTANOATE-->2-AMINO-6-T-BUTYL-4-(TRIFLUOROMETHYL)PYRIMIDINE-->2-AMINO-4-PHENYL-6-(TRIFLUOROMETHYL)PYRIMIDINE-->2-[1-METHYL-5-(TRIFLUOROMETHYL)PYRAZOL-3-YL]-THIOPHENE-5-CARBOXALDEHYDE-->EUROPIUM D-3-TRIFLUOROACETYLCAMPHORATE-->3-TRIFLUOROACETYL-D-CAMPHOR-->Efavirenz-->1,1,1-Trifluoro-2-hexanone-->8-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE-4-CARBONITRILE-->4-(TRIFLUOROMETHYL)-ALPHA,ALPHA,ALPHA-TRIFLUOROACETOPHENONE-->4,4,4-Trifluoro-1-phenyl-1,3-butanedione-->BENZALDEHYDE DIETHYL ACETAL-->1,1,1-TRIFLUORO-5,5-DIMETHYL-2,4-HEXANEDIONE-->2-(TRIFLUOROMETHYL)PYRIMIDINE-4,6-DIOL-->3'-METHOXY-2,2,2-TRIFLUOROACETOPHENONE-->3-PHENYL-1,1,1-TRIFLUOROPROPAN-2-ONE-->1-(2-AMINO-5-CHLOROPHENYL)-2,2,2-TRIFLUOROETHANONE

Shop 3-Chloro-1-propene107-05-1-Detailed Image 2

Basic Info

Product Name:

Ethyl trifluoroacetate

Other Name:

Acetic acid,2,2,2-trifluoro-,ethyl ester;Acetic acid,trifluoro-,ethyl ester;Ethyl trifluoroacetate;Ethyl perfluoroacetate;Trifluoroacetic acid ethyl ester;NSC 220215;Ethyl α,α,α-trifluoroacetate;Ethyl 2,2,2-trifluoroacetate;7: PN: WO2007101224 PAGE: 36 claimed sequence

CAS No.:

383-63-1

Molecular Formula:

C4H5F3O2

InChIKeys:

InChIKey=STSCVKRWJPWALQ-UHFFFAOYSA-N

Molecular Weight:

142.07700

Exact Mass:

142.08

EC Number:

206-851-6

UNII:

A6TZK6X11X

NSC Number:

220215

DSSTox ID:

DTXSID8041959

HScode:

2915900090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

26.30000

XLogP3:

1.11180

Appearance:

Liquid

Density:

1.1952 g/cm³ @ Temp: 16.7 °C

Melting Point:

-78ºC

Boiling Point:

61 °C

Flash Point:

-1ºC

Refractive Index:

1.306-1.308

Water Solubility:

HYDROLYSIS

Storage Conditions:

2-8ºC

See More Ethyl trifluoroacetate Properties 

Hazard Identification

Classification of the substance or mixture

Flammable liquids, Category 2

Eye irritation, Category 2

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H225 Highly flammable liquid and vapour H319 Causes serious eye irritation H412 Harmful to aquatic life with long lasting effects
Prevention	P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P264 Wash ... thoroughly after handling. P273 Avoid release to the environment.
Response	P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage	P403+P235 Store in a well-ventilated place. Keep cool.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Ethyl trifluoroacetate Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

4 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Ethyl trifluoroacetate	20 MT	May 20, 2024
India	Ethyl Trifluoroacetate	1.00 KG	Apr 3, 2025
India	Ethyl trifluoro acetate	5 MT	Jul 12, 2024
India	Ethyl Trifluoroacetate	1 KG	Apr 2, 2025

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