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(-)-EGCG-3''-O-ME

Unit Price:

$6000-6500/G EXW

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CAS No.:

83104-87-4

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Packaging:

20mg

Price valid (until):

2026-07-23

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Description
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Description

(-)-Epigallocatechin-3-(3''-O-methyl) gallate, commonly abbreviated as (-)-EGCG-3''-O-Me, is a naturally occurring methylated derivative of EGCG (the main antioxidant found in green tea). It is isolated from specialized green tea cultivars, such as Benifuki tea.

The addition of the methyl group slightly modifies its chemical structure, granting it a significantly higher bioavailability and greater metabolic stability than standard EGCG. In biochemical and pharmacological research, its primary functions include:

Primary Biological and Pharmacological Functions

Potent Antiallergic Activity: (-)-EGCG-3''-O-Me is highly regarded for its anti-allergic properties. It works by suppressing FcεRI expression (the high-affinity IgE receptor) on the surface of mast cells and basophils. This action effectively prevents histamine release and dampens the allergic response.
Enhanced Bioavailability and Stability: Traditional EGCG degrades rapidly in the gut and is poorly absorbed. Because (-)-EGCG-3''-O-Me is methylated, it resists rapid enzymatic breakdown in the liver, resulting in an estimated 2.5 times higher bioavailability in plasma and tissues.
Anti-Inflammatory Effects: It acts as a powerful anti-inflammatory agent. It downregulates pro-inflammatory cytokines and signaling molecules (like the NF-κB pathway), minimizing systemic inflammation and tissue irritation.
Strong Antioxidant and Lipid Protection: It functions as a potent free radical scavenger. Research shows it inhibits lipid oxidation (including the oxidation of oils and fats), shielding cells from oxidative stress and protecting cell membranes from lipid peroxidation.
Cytotoxic and Anti-Cancer Potential: It displays selective cytotoxic activity against various cancer cell lines. It works by modulating cellular energy pathways and prompting apoptosis (programmed cell death) in mutated or malignant cells.
Cell and Tissue Preservation: In specialized cellular research, (-)-EGCG-3''-O-Me has demonstrated the unique ability to assist in the cold preservation of primary rat hepatocytes (liver cells), helping maintain cell viability during storage.

Basic Info

Product Name:

Epigallocatechin 3-O-(3-O-methyl)gallate

Other Name:

Benzoic acid,3,4-dihydroxy-5-methoxy-,(2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester;Benzoic acid,3,4-dihydroxy-5-methoxy-,3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester,(2R-cis)-;(-)-Epigallocatechin 3-O-(3-O-methylgallate);Epigallocatechin 3-O-(3-O-methyl)gallate;(-)-Epigallocatechin 3-(3′′-O-methyl)gallate;EGCG3′′Me

CAS No.:

83104-87-4

Molecular Formula:

C23H20O11

InChIKeys:

InChIKey=WVRDOLPMKOCJRJ-DENIHFKCSA-N

Molecular Weight:

472.4

Exact Mass:

472.40

EC Number:

2017-001-1

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

186

XLogP3:

2.03

Density:

1.77

Melting Point:

221-223 °C (decomp)

Boiling Point:

856.1±65.0 °C at 760 mmHg

Flash Point:

298.9±27.8 °C

Refractive Index:

1.796

See More Epigallocatechin 3-O-(3-O-methyl)gallate Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Epigallocatechin 3-O-(3-O-methyl)gallate Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

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(-)-EGCG-3''-O-ME

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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