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AkebiasaponinD

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Unit Price:

$1100-1200/G EXW

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CAS No.:

39524-08-8

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Packaging:

20mg

Price valid (until):

2026-07-23

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Description
Seller Information
Inquiry History

Description

Akebiasaponin D (also known as asperosaponin VI) is a major bioactive triterpenoid saponin extracted primarily from the roots of Dipsacus asper (Xu Duan / Japanese Teasel), a foundational herb in traditional medicine.

In modern clinical pharmacology, it acts as a multitargeting agent that preserves bone architecture, counters neuroinflammation, shields the liver, and fights obesity.

Primary Biological and Pharmacological Functions

Anti-Osteoporotic and Bone Fracture Repair: Reflecting its traditional use to "strengthen muscles and bones," Akebiasaponin D is widely utilized as a potent anti-osteoporosis agent. It accelerates bone fracture healing and preserves bone microarchitecture by inhibiting osteoclastic (bone-resorbing) activity and preventing bone destruction.
Potent Anti-Inflammatory Effects: In conditions like rheumatoid arthritis, it curtails the M1 macrophage inflammatory response. It downregulates the STAT3 signaling pathway and blocks high levels of DNA methyltransferase 3b (DNMT3b). This significantly suppresses key inflammatory cytokines, including nitric oxide (NO), TNF-α, and IL-6.
Neuroprotection and Anti-Alzheimer's Activity: It guards central nervous tissues against neurodegenerative damage. Research shows it protects brain cells against amyloid-beta (Aβ) cytotoxicity and curbs neuroinflammation by blocking Akt, IKK, and NF-κB pathways. This prevents memory dysfunction and slows down cognitive deficits.
Anti-Obesity and Thermogenesis Activation: It functions as a metabolic activator to treat high-fat diet-induced obesity. By targeting the USP4 enzyme, it deubiquitinates and stabilizes PPARγ, avoiding its degradation. This triggers brown adipose tissue thermogenesis and upgrades mitochondrial quality to burn fat.
Hepatoprotection Against Fatty Liver: It blocks lipid accumulation and counters Non-Alcoholic Fatty Liver Disease (NAFLD). It helps mitigate hepatic steatosis and prevents liver cell death (apoptosis) by modulating cellular autophagic flux.
Skeletal Muscle Insulin Sensitivity: It reduces skeletal muscle insulin resistance triggered by high-fat diets. It stabilizes blood sugar and assists in regulating glucose-lipid metabolism balance.

Basic Info

Product Name:

Asperosaponin VI

Other Name:

Olean-12-en-28-oic acid,3-(α-L-arabinopyranosyloxy)-23-hydroxy-,6-O-β-D-glucopyranosyl-β-D-glucopyranosyl ester,(3β,4α)-;Akebia saponin D;Tauroside St-G0-1;Hederagenin 3-O-α-L-arabinopyranosyl-28-β-D-glucopyranosyl(1→6)-β-D-glucopyranoside;Asperosaponin VI;3-O-α-L-Arabinopyranosylhederagenin 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside;Leiyemudanoside A

CAS No.:

39524-08-8

Molecular Formula:

C47H76O18

InChIKeys:

InChIKey=CCRXMHCQWYVXTE-HMRSNRLKSA-N

Molecular Weight:

929.099

Exact Mass:

929.10

DSSTox ID:

DTXSID60856146

HScode:

29389090

Categories:

Chinese Herbs

Characteristics

PSA:

294.98000

XLogP3:

-0.24800

Density:

1.43

Melting Point:

234-235 °C

Flash Point:

282.1±27.8 °C

Refractive Index:

1.627

See More Asperosaponin VI Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Asperosaponin VI Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Saponin	400 KG	Jan 24, 2024

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