Methanol Basic information
Introduction Chemical Properties Uses Methanol poisoning and First Aid Measures Reactivities of Methanol Production Toxicity evaluation Methanol gasoline
Product Name:
Methanol
Synonyms:
METHYL RED MIXED SOLUTION;METHYL RED, NEUTRAL;METHYL RED MIXED SOLUTION R;METHYL RED INDICATOR;METHYL RED ETHANOL;METHYL RED, WATER SOLUBLE;METHYL RED, SPIRIT SOLUBLE;METHYL RED SOLUTION R
CAS:
67-56-1
MF:
CH4O
MW:
32.04
EINECS:
200-659-6
Product Categories:
Solvents for GC applications;Solvents for LC-ICP-MS;Solvents for Metal Speciation Analysis;Solvents for Speciation Analysis (LC-ICP-MS);Spectroscopy;Toxins (other than pesticide/drug residues);Trace Analysis Reagents &;Purge &;Purge and Trap Solvents;Trap Solvents;Carbohydrates (sugars;Dietary Fiber;Non-Nutritional In;saccharides);Amber Glass Bottles;Blends - CHROMASOLV for HPLCSemi-Bulk Solvents;Amino Acids;and Triglycerides;Artificial Sweeteners;Di;Food Dyes;Mono;Mycotoxins;Anhydrous;Anhydrous Solvents;Sure/Seal Bottles;CHROMASOLV Gradient;Composite Drums;HPLC Gradient Grade Solvents (CHROMASOLV);NOWPak Products;Blends- CHROMASOLV for HPLCSolvents;CHROMASOLV Solvents (HPLC, LC-MS);CHROMASOLV(R) HPLC Grade SolventsSolvents;Pre-Blended Mobile Phase Solvents;Solvent Bottles;VerSA-Flow? Products;HPLC &;HPLC Grade Solvents (CHROMASOLV);HPLC/UHPLC Solvents (CHROMASOLV);Pre-Blended Mobile Phase Solvents;Products;Returnable Containers;Semi-Bulk Solvents;Solvent by Application;UHPLC Solvents (CHROMASOLV);Allium cepa (Onion);ACS and Reagent Grade Solvents;Carbon Steel Flex-Spout Cans;Citrus aurantium (Seville orange);Nutrition Research;Phytochemicals by Plant (Food/Spice/Herb);Reagent;ReagentPlus;ReagentPlus Solvent Grade Products;ACS Grade;ACS Grade Solvents;Closed Head Drums;Drums Product Line;META - METH;Alcohols;Aliphatic;Alpha Sort;Chemistry;&;Buffers and Reagents;Core Bioreagents;Hematology and Histology Lab Accessories;Life Science Reagents for Immunohistochemistry (IHC);Organic Solvents;Protein Electrophoresis;Solvent by Type;Western Blotting;Buffers;Fixatives;Hematology and Histology;Methanol;Proteomics;Reagents;Research Essentials;Solvents;Stains;Aluminum Bottles;Solvent Bottles;Solvent Packaging Options;Blends - CHROMASOLV for HPLC;Blends- CHROMASOLV for HPLC;VerSA-Flow Products;Amber Glass Bottles;Analytical Reagents;Analytical/Chromatography;Chromatography Reagents &;Alphabetic;Analytical Standards;Chemical Class;Chromatography;Environmental Standards;M;Volatiles/ Semivolatiles;Apoptosis and Cell Cycle;Other Apoptosis Related Reagents;Cell Biology;Cell Signaling and Neuroscience;General Reagents;Life Science Reagents for Western Blotting;NMR;Spectrophotometric Grade;Spectrophotometric Solvents;Spectroscopy Solvents (IR;UV/Vis);CHROMASOLV Plus;HPLC Plus Grade Solvents (CHROMASOLV);PVC Coated Bottles;CHROMASOLV for HPLC;Plastic Bottles;3-MCPD;Acrylamide;Adulterants;Allergens;and NOGE;Applications;BADGE;Benzene;Beverage Analysis;Beverages;BFDGE;Algicide, bactericide, deodorant, fungicide, in sugar refining, oxidizing agent, bleaching agent, disinfectant.;Organics;1-Alkanols;Analytical Chemistry;Monofunctional & alpha,omega-Bifunctional Alkanes;Monofunctional Alkanes;Solvents for HPLC & Spectrophotometry;Solvents for Spectrophotometry;HPLC Solvents;LEDA HPLC;Bisphenol A (BPA);Derivatization of Fatty Acids to FAMEs;Dioxins/Furans/PCBs;Disinfection Product Residues and Solvents;Edible Oils;Essential Oils;FAMEs;FAMEs by Boiling Point Elution;FAMEs by Degree of Unsaturation;Fats (fatty acids;Flavors &;Food &;Fractionation of FAMEs Using Silver-Ion SPE;Fragrances;Free Fatty Acids;Furans;GC Solvents;glycerides);Honey;Melamine;Sterols;GC-MS Solvents;Heavy Metals;ICP-OES/-MS;Reagents for Inorganic Trace Analysis;67-56-1;1;A
Mol File:
67-56-1.mol

Methanol Chemical Properties
Melting point
-98 °C(lit.)
Melting point
-97,8°C
Boiling point
64,7°C
Boiling point
65.4 °C(lit.)
density
0.791 g/mL at 25 °C
density
d = 0,89
vapor density
1.11 (vs air)
vapor pressure
410 mm Hg ( 50 °C)
refractive index
n20/D 1.329(lit.)
Fp
52 °F
storage temp.
2-8°C
solubility
benzene: miscible(lit.)
pka
15.2(at 25℃)
form
Liquid Free From Particulates
color
<10(APHA)
Specific Gravity
0.793 (20/20℃)
Relative polarity
0.762
PH
6.8 (20°C in H2O)
Odor
Faint alcohol odor detectable at 4 to 6000 ppm (mean = 160 ppm)
Flame Color
Pale blue
explosive limit
5.5-44%(V)
Odor Threshold
33ppm
Water Solubility
miscible
Thermal Conductivity
0.2002 W/(m·K) at 25 ℃
λmax
λ: 210 nm Amax: 0.50
λ: 220 nm Amax: 0.30
λ: 230 nm Amax: 0.15
λ: 235 nm Amax: 0.10
λ: 240 nm Amax: 0.05
λ: 260 nm Amax: 0.01
λ: 400 nm Amax: 0.01
Merck
14,5957
BRN
1098229
Henry's Law Constant
4.99 at 25 °C (headspace-GC, Gupta et al., 2000)
Exposure limits
ACGIH TLV-TWA:(200 ppm)
OSHA PEL-TWA:200 ppm (260 mg/m³)
NIOSH REL-TWA:200 ppm;REL-STEL:250 ppm;REL-IDLH:25,000 ppm
Dielectric constant
33.6（20℃）
Cosmetics Ingredients Functions
SOLVENT
FRAGRANCE
DENATURANT
Cosmetic Ingredient Review (CIR)
Methanol (67-56-1)
InChI
1S/CH4O/c1-2/h2H,1H3
InChIKey
OKKJLVBELUTLKV-UHFFFAOYSA-N
SMILES
CO
LogP
-0.770
Surface tension
22.22mN/m at 298.15K
Surface tension
22.7mN/m at 20°C
CAS DataBase Reference
67-56-1(CAS DataBase Reference)
NIST Chemistry Reference
Methyl alcohol(67-56-1)
EPA Substance Registry System
Methanol (67-56-1)
Absorption
in accordance
Safety Information
Hazard Codes
Xn,T,F
Risk Statements
10-20/21/22-68/20/21/22-39/23/24/25-23/24/25-11-40-36-36/38-23/25
Safety Statements
36/37-7-45-16-24/25-23-24-26
RIDADR
UN 1230
OEB
A
OEL
TWA: 200 ppm (260 mg/m3), STEL: 250 ppm (325 mg/m3) [skin]
WGK Germany
1
RTECS
PC1400000
F
3-10
Autoignition Temperature
385 °C
TSCA
TSCA listed
HS Code
2905 11 00
HazardClass
3
PackingGroup
II
Storage Class
3 - Flammable liquids
Hazard Classifications
Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Flam. Liq. 2
STOT SE 1
Hazardous Substances Data
67-56-1(Hazardous Substances Data)
Toxicity
LD50 oral (rat)
5628 mg/kg
LD50 skin (rabbit)
15,840 mg/kg
LC50 inhal (rat)
>145,000 ppm (1 h)
PEL (OSHA)
200 ppm (260 mg/m3)
TLV-TWA (ACGIH)
200 ppm (260 mg/m3)—skin
STEL (ACGIH)
250 ppm (328 mg/m3)
IDLH
6,000 ppm

MSDS Information
Provider
Language
Carbinol
English
SigmaAldrich
English
ACROS
English
ALFA
English
Methanol Usage And Synthesis

Introduction
Methanol is the simplest fatty alcohol. It is a colorless, flammable, irritating liquid with a boiling point of 64.7°C, a melting point of -93.90°C, and a relative density of 0.7913. Soluble in water and most organic solvents. Its severe toxicity can damage the optic nerve. Once swallowed, it can make the eyes blind and even cause death.
Methanol has the general properties of a primary aliphatic alcohol. The three hydrogen atoms on a carbon atom with a hydroxyl group can be oxidized, orderly generating formaldehyde, formic acid, and carbon dioxide. Therefore, it is largely used in the synthesis of formaldehyde. Methanol is easily converted into important organic synthesis intermediates such as methyl carboxylate, methyl chloride and it is also applied as important organic solvents, extraction agents and alcohol denaturants.
Chemical Properties
Methanol is a clear, colorless liquid with a characteristic pungent odor (NTP NIEHS web accessed 2/16/2013). The air odor threshold has been reported as 1500 ppm (approximately 2000mg/m3), much higher than the occupational guidelines.

Methanol (methyl alcohol; wood alcohol) is used extensively as a solvent for lacquers, paints, varnishes, cements, inks, dyes, plastics, and various industrial coatings. Large quantities are used in the production of formaldehyde and other chemical derivatives such as acetic acid, methyl halides and terephthalate, methyl methacrylate, and. Methanol is also used as a gasoline additive, as a component of lacquer thinners, in antifreeze preparations of the “nonpermanent” type, and in canned heating preparations of jellied alcohol. It is also used in duplicating fluid, in paint removers, and as a cleaning agent. The potential for methanol as a future alternative for gasoline indicates that the use of this chemical will most likely increase rather than decrease. At room temperature, methanol is a colorless liquid with a pungent odor. It is relatively volatile, with a vapor pressure of 96 mmHg and a vapor density of 1.11. It is miscible with water and soluble with other organic solvents. It is found in nature as a fermentation product of wood and as a constituent of some fruits and vegetables.

Uses
Methanol is an important chemical raw material for fine chemicals. Its carbonylation at 3.5 MPa and 180-200° C in the presence of catalyst can produce acetic acid and further produce . It reacts with syngas to prepare vinyl acetate in the presence of catalyst; reacts with isobutylene to produce tert-butyl methyl ether; prepare dimethyl oxalate through oxidization and carbonylation, and a further hydrogenation to produce ethylene glycol; reacts with toluene under catalyst and simultaneous oxidization to produce phenylethyl alcohol. It can be used as a good solvent, as a pesticide raw material, as an antifreeze agent, as a fuel and fuel additive (this is receiving increasing attention in environmental protection field). It is the main raw material in the preparation of formaldehyde, the raw material in and spices production, a solvent in dyes and paint industries, the raw material in preparation of methanol single cell protein and synthesis of methyl ester.
Industry
Applications
Role/Benefit
Laboratory
HPLC, UV/VIS spectroscopy, and LCMS
Low UV cutoff
Chemical manufacture
Production of formaldehyde and its derivates
Main feedstock
Production of hydrocarbon chains and even aromatic systems
Main feedstock
Production of methyl tert-butyl ether
Methylation reagent
Production of dimethyl terephthalic acid, methyl methacrylate and acrylic acid methyl ester
Main feedstock
Plastics
Production of polymers
Main feedstock
Farm chemical
Production of insecticide and acaricide
Main feedstock
Production of sulfonamides, amycin, etc
Main feedstock
Fuel for vehicles
Pure methanol fuel
Pure methanol does not produce an opaque cloud of smoke in the event of an accident
Methanol gasoline
Blended directly into gasoline to produce a high-octane, efficient fuel with lower emissions than conventional gasoline
Chemical analysis
Determination of boron
Analysis agent
Determination of trace moisture in alcohols, saturated hydrocarbons, benzene, pyridine
Analysis agent
Others
Separation of calcium sulfate and magnesium sulfate
Separation reagent
Separation of strontium bromide and barium bromide
Separation reagent
Anti-freezing agent
Effective component
Methanol poisoning and First Aid Measures
Pathogenesis
First, methanol has a cumulative effect and is oxidized in the body into more toxic formaldehyde and formic acid. Methanol and its oxides directly damage the tissues, causing cerebral edema, meningeal hemorrhage, optic nerve and retinal atrophy, pulmonary congestion and edema, and hepatic and renal turbid swelling.
Second, methanol and its oxides cause blood circulation disorder, coenzyme system obstacles in vivo, resulting in lack of oxygen supply to the brain cortical cells, metabolic disorders, and related neurological and psychiatric symptoms.
Third, methanol oxidation products combine with the iron in the cytochrome oxidase, which inhibits the intracellular oxidation process thus causing metabolic disorders, acidosis along with organic acid accumulation in the body, and nerve cells impair.
Treatment
• Keep away from the methanol dispersion area, excrete methanol from the body.
Antidote: Ethanol is an antidote to methanol poisoning. Ethanol can prevent methanol’s oxidation and promote its emission. Prepare 5% ethanol solution using 10% glucose solution, and drip slowly .
• Maintain electrolyte balance: maintain respiratory and circulatory function, provide with a large number of Vitamin B.
Treatment of acidosis: Administrate timely sodium bicarbonate solution or sodium lactate solution based on blood gas analysis, carbon dioxide binding force measurement and clinical performance.
• Prevent cerebral edemas actively, reduce intracranial pressure, improve fundus blood circulation, and prevent optic neuropathy if needed.
• cytochrome C, polar fluid to restore cytochrome oxidase function.
• Control mental state by applying , perphenazine and the like.
Symptoms and treatments:
Acute pain
Convulsions, amimystrine,
Coma
ophylline
Reactivities of Methanol
Methanol is the simplest aliphatic alcohol. It contains only one carbon atom. Unlike higher alcohols, it cannot form an olefin through dehydration. However, it can undergo other typical reactions of aliphatic alcohols involving cleavage of a C-H bond or O-H bond and displacement of the -OH group. Table 1 summarizes the reactions of methanol, which are classified in terms of their mechanisms. Examples of the reactions and products are given.
Homolytic dissociation energies of the C-O and O-H bonds in methanol are relatively high. Catalysts are often used to activate the bonds and to increase the selectivity to desired products.

Production
Methanol is prepared by pressure heating with carbon monoxide and hydrogen in the presence of a catalyst:

If the conditions are strictly controlled, the yield can reach 100% and the purity can reach 99%. Methane is mixed with oxygen (9:1, V/V) and methanol is obtained through a copper tube under heating and pressure:

Methanol gasoline
Methanol gasoline refers to the M series mixture fuel made of addition of methanol to the gasoline and formulated using methanol fuel solvent. Among them, M15 (add 15% methanol in gasoline) clean methanol gasoline is used as vehicle fuel, respectively, used in a variety of gasoline engines. It can be applied to substitute the finished gasoline without changing the existing engine structure, and can also be mixed with refined oil. The methanol mixed fuel has excellent thermal efficiency, power, start-up and being economical. It is also characterized by lowering the emissions, saving oil and being safe and convenient. Methanol gasoline types of M35, M15, M20, M50, N85 and M100 with different blend ratios have been developed around the world according to the conditions of different countries. At present, the commercial methanol is mainly M85 (85% methanol + 15% gasoline) and M100 with M100 performance being better than M85 and having greater environmental advantages.
Description
Methanol is flammable and irritant, suitable as industrial denaturant for ethanol. Avoid inhalation, skin contact and oral intake during operation.
Chemical Properties
Methanol is a clear, water-white liquid with a mild odor at ambient temperatures.The air odor threshold for methanol has been reported as 100 ppm . Others have reported that 2000 or 5900 ppm methanol is barely detectable .
Physical properties
Clear, colorless liquid with a characteristic alcoholic odor. Odor threshold concentrations ranged from 8.5 ppbv (Nagata and Takeuchi, 1990) to 100.0 ppmv (Leonardos et al., 1969). Experimentally determined detection and recognition odor threshold concentrations were 5.5 mg/m3 (4.2 ppmv) and 69 mg/m3 (53 ppmv), respectively (Hellman and Small, 1974).
History
It was first isolated in 1661 by the Irish chemist Robert Boyle (1627–1691) who prepared it by the destructive distillation of boxwood, giving it the name spirit of box, and the name wood alcohol is still used for methyl alcohol. Methyl alcohol is also called pyroxylic spirit; pyroxylic is a general term meaning distilled from wood and indicates that methyl alcohol is formed during pyrolysis of wood. The common name was derived in the mid-1800s. The name methyl denotes the single carbon alkane methane in which a hydrogen atom has been removed to give the methyl radical. The word alcohol is derived from Arabic al kuhul.
Uses
Methanol has numerous uses. Its main use is in the production of formaldehyde, whichconsumes approximately 40% of methanol supplies. Methanolis a common organic solvent found in many products including deicers (windshield wiperfl uid), antifreezes, correction fl uid, fuel additives, paints, and other coatings. A number ofindustrial chemicals use methanol in their production. Among these are methyl methacrylateand dimethyl terephthalate. Methanol is used to convert methylacrylamide sulfate to methylmethacrylate and ammonium hydrogen sulfate (NH4HSO4):
Methanol is used in making the ester dimethyl terephthalate from mixtures ofxylene of toluene. Dimethyl terephthalate is used in the manufacture of polyesters and plastics.
Methanol is used as a fuel additive. The common gasoline additive HEET is pure methanoland is used as a gas-line antifreeze and water remover. Methanol is used as a fuel in camp stoves and small heating devices. It is used to fuel the small engines used in models (airplanes,boats). In the early history of automobiles,methanol was a common fuel. The availability of cheap gasoline replaced methanol in the1920s, but it is receiving renewed interest as an alternative fuel as the demand and cost of oilincrease and oil supplies become uncertain. Methanol can be produced from coal and biomass.Methanol has a higher octane rating and generally lower pollutant emissions compared togasoline. The relatively low flame temperature means that fewer nitrogen oxides are producedby methanol than by ethanol. One large disadvantage of methanol is that it has a lower energydensity than gasoline. Using equivalent volumes of gasoline and methanol, methanol givesabout half the mileage of gasoline. Another problem with methanol is its low vapor pressure,resulting in starting problems on cold days. This problem can be mitigated by using a blendof 85% methanol and 15% gasoline. This mixture is called M85 and is similar to E85 ethanol(see Ethyl Alcohol).
Uses
Methanol is used in the production offormaldehyde, acetic acid, methyl tert-butylether, and many chemical intermediates; asan octane improver (in oxinol); and as apossible alternative to diesel fuel; being anexcellent polar solvent, it is widely used as acommon laboratory chemical and as a methylating reagent.
Uses
high purity grade for ICP-MS detection
Uses
. Methyl alcoholis miscible in all proportions with water,ethyl alcohol, and ether. It burns with a light blue flame producing water and carbon dioxide. This vapor forms an explosive mixture(6.0 to 36.5% by volume) with air. Methyl alcohol is an important inexpensive raw material that is synthetically produced for the organic chemical industry. Nearly half of the methyl alcohol manufactured is used in the production of formaldehyde. Other uses of methyl alcohol are as an antifreeze and fuel for automobiles and as an intermediate in the production of synthetic protein.
Uses
Industrial solvent. Raw material for making formaldehyde and methyl esters of organic and inorganic acids. Antifreeze for automotive radiators and air brakes; ingredient of gasoline and diesel oil antifreezes. Octane booster in gasoline. As fuel for picnic stoves and soldering torches. Extractant for animal and vegetable oils. To denature ethanol. Softening agent for pyroxylin plastics. Solvent and solvent adjuvant for polymers. Solvent in the manufacture of cholesterol, streptomycin, vitamins, hormones, and other pharmaceuticals.
Definition
ChEBI: Methanol is the primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group. It has a role as an amphiprotic solvent, a fuel, a human metabolite, an Escherichia coli metabolite, a mouse metabolite and a Mycoplasma genitalium metabolite. It is an alkyl alcohol, a one-carbon compound, a volatile organic compound and a primary alcohol. It is a conjugate acid of a methoxide.
Production Methods
Modern industrial-scale methanol production is exclusively based on synthesis from pressurized mixtures of hydrogen, carbon monoxide, and carbon dioxide gases in the presence of catalysts. Based on production volume, methanol has become one of the largest commodity chemicals produced in the world.
Reactions
Methyl alcohol is a versatile material, reacting (1) with sodium metal, forming sodium methylate, sodium methoxide CH3ONa plus hydrogen gas, (2) with phosphorus chloride, bromide, iodide, forming methyl chloride, bromide, iodide, respectively, (3) with H2SO4 concentrated, forming dimethyl ether (CH3)2O, (4) with organic acids, warmed in the presence of H2SO4, forming esters, e.g., methyl acetate CH3COOCH3, [CAS: 79-20-9], methyl salicylate C6H4(OH)·COOCH3, possessing characteristic odors, (5) with magnesium methyl iodide in anhydrous ether (Grignard’s solution), forming methane as in the case of primary alcohols, (6) with calcium chloride, forming a solid addition compound 4CH3OH·CaCl2, which is decomposed by H2O, (7) with oxygen, in the presence of heated smooth copper or silver forming formaldehyde. The density of pure methyl alcohol is 0.792 at 20 °C compared with H2O at 4 °C (the corresponding figure for ethyl alcohol is 0.789), and the percentage of methyl alcohol present in a methyl alcohol-water solution may be determined from the density of the sample.
World Health Organization (WHO)
Methanol continues to be used as an industrial solvent.
General Description
A colorless fairly volatile liquid with a faintly sweet pungent odor like that of ethyl alcohol. Completely mixes with water. The vapors are slightly heavier than air and may travel some distance to a source of ignition and flash back. Any accumulation of vapors in confined spaces, such as buildings or sewers, may explode if ignited. Used to make chemicals, to remove water from automotive and aviation fuels, as a solvent for paints and plastics, and as an ingredient in a wide variety of products.
Reactivity Profile
Methanol reacts violently with acetyl bromide [Merck 11th ed. 1989]. Mixtures with concentrated sulfuric acid and concentrated can cause explosions. Reacts with hypochlorous acid either in water solution or mixed water/carbon tetrachloride solution to give methyl hypochlorite, which decomposes in the cold and may explode on exposure to sunlight or heat. Gives the same product with chlorine. Can react explosively with isocyanates under basic conditions. The presence of an inert solvent mitigates this reaction [Wischmeyer 1969]. A violent exothermic reaction occurred between methyl alcohol and bromine in a mixing cylinder [MCA Case History 1863. 1972]. A flask of anhydrous lead perchlorate dissolved in Methanol exploded when Methanol was disturbed [J. Am. Chem. Soc. 52:2391. 1930]. P4O6 reacts violently with Methanol. (Thorpe, T. E. et al., J. Chem. Soc., 1890, 57, 569-573). Ethanol or Methanol can ignite on contact with a platinum-black catalyst. (Urben 1794).
Fire Hazard
Behavior in Fire: Containers may explode.
Flammability and Explosibility
Methanol is a flammable liquid (NFPA rating = 3) that burns with an invisible flame in daylight; its vapor can travel a considerable distance to an ignition source and "flash back." Methanol-water mixtures will burn unless very dilute. Carbon dioxide or dry chemical extinguishers should be used for methanol fires.
reaction suitability
reaction type: volumetric
Chemical Reactivity
Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization:Not pertinent; Inhibitor of Polymerization: Not pertinent.
Potential Exposure
Drug,Mutagen; Reproductive Effector; Human Data; PrimaryIrritant. Methyl alcohol is used as a starting material inorganic synthesis of chemicals, such as formaldehyde,methacrylates, methyl halides, ethylene glycol, and pesticides, and as an industrial solvent for inks, resins, adhesives, and dyes. It is an ingredient in paint and varnish removers, cleaning and dewaxing preparations, spirit duplicating fluids, embalming fluids, antifreeze mixtures, and enamels, and is used in the manufacture of photographic film, plastics, celluloid, textile soaps, wood stains, coated fabrics, shatterproof glass, paper coating, waterproofing formulations, artificial leather, and synthetic indigo and other dyes. It has also been used as an extractant in many other processes, an antidetonant fuel-injection fluid for aircraft, a rubber accelerator, and a denaturant for ethyl alcohol.
First aid
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
Source
Methanol occurs naturally in small-flowered oregano (5 to 45 ppm) (Baser et al., 1991), Guveyoto shoots (700 ppb) (Baser et al., 1992), orange juice (0.8 to 80 ppm), onion bulbs, pineapples, black currant, spearmint, apples, jimsonweed leaves, soybean plants, wild parsnip, blackwood, soursop, cauliflower, caraway, petitgrain, bay leaves, tomatoes, parsley leaves, and geraniums (Duke, 1992).
Methanol may enter the environment from methanol spills because it is used in formaldehyde solutions to prevent polymerization (Worthing and Hance, 1991).
Environmental fate
Biological. In a 5-d experiment, [14C]methanol applied to soil water suspensions under aerobic and anaerobic conditions gave 14CO2 yields of 53.4 and 46.3%, respectively (Scheunert et al., 1987). Heukelekian and Rand (1955) reported a 5-d BOD value of 0.85 g/g which is 56.7% of the ThOD value of 1.50 g/g. Using the BOD technique to measure biodegradation, the mean 5-d BOD value (mM BOD/mM methanol) and ThOD were 0.93 and 62.0%, respectively (Vaishnav et al., 1987).
Photolytic. Photooxidation of methanol in an oxygen-rich atmosphere (20%) in the presence of chlorine atoms yielded formaldehyde and hydroxyperoxyl radicals. The reaction is initiated via hydrogen abstraction by OH radicals or chlorine atoms yielding a hydroxymethyl radical. Chlorine, formaldehyde, carbon monoxide, and formic acid were detected (Whitbeck, 1983). Reported rate constants for the reaction of methanol and OH radicals in the atmosphere: 5.7 x 10-11 cm3/mol·sec at 300 K (Hendry and Kenley, 1979), 5.7 x 10-8 L/mol·sec (second-order) at 292 K (Campbell et al., 1976), 1.00 x 10-12 cm3/molecule·sec at 292 K (Meier et al., 1985), 7.6 x 10-13 cm3/molecule·sec at 298 K (Ravishankara and Davis, 1978), 6.61 x 10-13 cm3/molecule·sec at room temperature (Wallington et al., 1988a). Based on an atmospheric OH concentration of 1.0 x 106 molecule/cm3, the reported half-life of methanol is 8.6 d (Grosjean, 1997).
Chemical/Physical. In a smog chamber, methanol reacted with nitrogen dioxide to give methyl nitrite and nitric acid (Takagi et al., 1986). The formation of these products was facilitated when this experiment was accompanied by UV light (Akimoto and Takagi, 1986). Methanol will not hydrolyze because it does not have a hydrolyzable functional group (Kollig, 1993).
At an influent concentration of 1,000 mg/L, treatment with GAC resulted in an effluent concentration of 964 mg/L. The adsorbability of the carbon used was 7 mg/g carbon (Guisti et al., 1974).
Hydroxyl radicals react with methanol in aqueous solution at a reaction rate of 1.60 x 10-12 cm3/moleculesec (Wallington et al., 1988).
Complete combustion in air produces carbon dioxide and water. The stoichiometric equation for this oxidation reaction is:
2CH4O + 3O2 → 2CO2 + 4H2O
storage
Methanol should be used only in areas free of ignition sources, and quantities greater than 1 liter should be stored in tightly sealed metal containers in areas separate from oxidizers.
Shipping
UN1230 Methanol, Hazard Class: 3; Labels: 3-Flammable liquid, 6.1-Poisonous material. (International)
Purification Methods
Almost all methanol is now obtained synthetically. Likely impurities are water, acetone, formaldehyde, ethanol, methyl formate and traces of dimethyl ether, methylal, methyl acetate, acetaldehyde, carbon dioxide and ammonia. Most of the water (down to about 0.01%) can be removed by fractional distillation. Drying with CaO is unnecessary and wasteful. Anhydrous methanol can be obtained from "absolute" material by passage through Linde type 4A molecular sieves, or by drying with CaH2, CaSO4, or with just a little more sodium than required to react with the water present, in all cases the methanol is then distilled. Two treatments with sodium reduces the water content to about 5 x 10-5%. [Friedman et al. J Am Chem Soc 83 4050 1961.] Lund and Bjerrum [Chem Ber 64 210 1931] warmed clean dry magnesium turnings (5g) and iodine (0.5g) with 50-75mL of "absolute" methanol in a flask until the iodine disappeared and all the magnesium was converted to the methoxide. Up to 1L of methanol was added and, after refluxing for 2-3hours, it was distilled off, excluding moisture from the system. Redistillation from tribromobenzoic acid removes basic impurities and traces of magnesium oxides, and leaves conductivity-quality material. The method of Hartley and Raikes [J Chem Soc 127 524 1925] gives a slightly better product. This consists of an initial fractional distillation, followed by distillation from aluminium methoxide, and then ammonia and other volatile impurities are removed by refluxing for 6hours with freshly dehydrated CuSO4 (2g/L) while dry air is passed through: the methanol is finally distilled. (The aluminium methoxide is prepared by warming with aluminium amalgam (3g/L) until all the aluminium has reacted. The amalgam is obtained by warming pieces of sheet aluminium with a solution of HgCl2 in dry methanol.) This treatment also removes aldehydes. If acetone is present in the methanol, it is usually removed prior to drying. Bates, Mullaly and Hartley [J Chem Soc 401 1923] dissolved 25g of iodine in 1L of methanol and then poured the solution, with constant stirring, into 500mL of M NaOH. Addition of 150mL of water precipitated iodoform. The solution was allowed to stand overnight, filtered, then boiled under reflux until the odour of iodoform disappeared, and fractionally distilled. (This treatment also removes formaldehyde.) Morton and Mark [Ind Eng Chem (Anal Edn) 6 151 1934] refluxed methanol (1L) with furfural (50mL) and 10% NaOH solution (120mL) for 6-12hours, the refluxing resin carries down with it the acetone and other carbonyl-containing impurities. The alcohol was then fractionally distilled. Evers and Knox [J Am Chem Soc 73 1739 1951], after refluxing 4.5L of methanol for 24hours with 50g of magnesium, distilled off 4L of it, which they then refluxed with AgNO3 for 24hours in the absence of moisture or CO2. The methanol was again distilled, shaken for 24hours with activated alumina before being filtered through a glass sinter and distilled under nitrogen in an all-glass still. Material suitable for conductivity work was obtained. Variations of the above methods have also been used. For example, a sodium hydroxide solution containing iodine has been added to methanol and, after standing for 1day, the solution has been poured slowly into about a quarter of its volume of 10% AgNO3, shaken for several hours, then distilled. Sulfanilic acid has been used instead of tribromobenzoic acid in Lund and Bjerrum's method. A solution of 15g of magnesium in 500mL of methanol has been heated under reflux, under nitrogen, with hydroquinone (30g), before degassing and distilling the methanol, which was subsequently stored with magnesium (2g) and hydroquinone (4g per 100mL). Refluxing for about 12hours removes the bulk of the formaldehyde from methanol: further purification has been obtained by subsequent distillation, refluxing for 12hours with dinitrophenylhydrazine (5g) and H2SO4 (2g/L), and again fractionally distilling. [Beilstein 1 IV 1227.]
Incompatibilities
Methanol reacts violently with strong oxidizers, causing a fire and explosion hazard.
Toxics Screening Level
The Initial Threshold Screening Level (ITSL) is 20,000μg/m3 with 4-hour averaging time.
Waste Disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration
Methanol Preparation Products And Raw materials
Raw materials
Sodium hydroxide-->Hydrogen-->Carbon dioxide-->Oxygen-->CARBON MONOXIDE-->tert-Butyl methyl ether-->Lactic acid-->METALLURGICAL COKE-->HEAVY CUT RESIDUE OIL-->METHANE-->2 DIESEL FUEL-->Residuum-->L(+)-Lactic acid
Preparation Products
H-DL-PRO-OME HCL-->2-Amino-4-methoxypyridine-->1,5-NAPHTHALENEDISULFONIC ACID DISODIUM SALT, DIHYDRATE, 98-->3,5-Dimethoxybenzyl alcohol-->METHYL 3-AMINOBENZOATE-->3-Methacryloxypropyltrimethoxysilane-->3'-DIMETHYLAMINOACETOPHENONE-->5-METHYL-2-HEXANOL-->TETRAHYDRO-3-FUROIC ACID-->2-Quinolinemethanamine-->NICOTINIC ACID HYDRAZIDE-->5-Bromo-4,6-dihydroxypyrimidine-->1-(1,3-DIHYDRO-1-OXOISOBENZOFURAN-3-YL)UREA-->(1H-IMIDAZOL-2-YL)-METHANOL-->2-OXO-6-PHENYL-4-(TRIFLUOROMETHYL)-1,2-DIHYDRO-3-PYRIDINECARBONITRILE-->Ethyl 3-(benzylamino)propanoate-->METHYL TRICOSANOATE-->5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE-->Methyl 4-aminobutyrate hydrochloride-->N,N'-BISBENZYLIDENEBENZIDINE-->4-Hydroxy-5-fluorpyrimidine-->TRIETHYLENE GLYCOL MONOMETHYL ETHER-->1-Chloropinacolone-->Dipropylene glycol monomethyl ether-->3-(METHOXYCARBONYL)PYRIDINE-2-CARBOXYLIC ACID-->4-(METHOXYCARBONYL)NICOTINIC ACID-->Methyl 3,4-dimethylbenzoate-->4-Bromobenzyl alcohol-->4-MORPHOLINECARBOXAMIDINE-->2-Thiophenecarboxylic acid hydrazide-->MONO-METHYL GLUTARATE-->METHYL STEARATE-->2-Methoxy-3-isobutyl pyrazine-->Diphenyldimethoxysilane-->methylated albumin-->FEMA 2062-->3-Chloropropyltrimethoxysilane-->3-Glycidoxypropyltrimethoxysilane-->Vinyltrimethoxysilane-->Potassium methoxide
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