N-Methylpiperidine | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 626-67-5

N-Methylpiperidine Basic information
Product Name: N-Methylpiperidine
Synonyms: 1-METHYLPIPERIDINE;N-METHYLPIPERIDINE;NMPPR;N-MEPIP;N-methylpepiridine;1-methyl-piperidin;lk20;Piperidine,1-methyl-
CAS: 626-67-5
MF: C6H13N
MW: 99.17
EINECS: 210-959-9
Product Categories: Piperidine;Building Blocks;Heterocyclic Building Blocks;Piperidines;Alphabetical Listings;Flavors and Fragrances;M-N
Mol File: 626-67-5.mol
Shop N-Methylpiperidine626-67-5-Detailed Image 1

N-Methylpiperidine Chemical Properties
Melting point -50 °C
Boiling point 106-107 °C (lit.)
density 0.816 g/mL at 25 °C (lit.)
vapor pressure 35.7hPa at 20℃
refractive index n20/D 1.438
Fp 38 °F
storage temp. −20°C
solubility Chloroform (Sparingly), Methanol (Slightly)
pka 10.08(at 25℃)
form Liquid
color Clear colorless
PH 12 (100g/l, H2O, 20℃)
biological source synthetic
explosive limit 1.1-9.9%(V)
Water Solubility miscible
BRN 1073
Henry's Law Constant 2.4×10-1 mol/(m3Pa) at 25℃, Abraham et al. (1994)
Dielectric constant 2.5899999999999999
InChI 1S/C6H13N/c1-7-5-3-2-4-6-7/h2-6H2,1H3
InChIKey PAMIQIKDUOTOBW-UHFFFAOYSA-N
SMILES CN1CCCCC1
LogP 1.15 at 25℃
CAS DataBase Reference 626-67-5(CAS DataBase Reference)
NIST Chemistry Reference Piperidine, 1-methyl-(626-67-5)
EPA Substance Registry System Piperidine, 1-methyl- (626-67-5)

Safety Information
Hazard Codes C,F,T
Risk Statements 11-34-20/22-39/23/24/25-23/24/25-67-22-10-37
Safety Statements 7-16-26-36/37/39-45-9-33
RIDADR UN 2399
WGK Germany 3
RTECS TN1225000
F 3-10
TSCA TSCA listed
HazardClass 3
PackingGroup II
HS Code 29333999
Storage Class 3 - Flammable liquids
Hazard Classifications Acute Tox. 3 Inhalation
Acute Tox. 4 Dermal
Acute Tox. 4 Oral
Aquatic Chronic 3
Eye Dam. 1
Flam. Liq. 2
Skin Corr. 1B
Toxicity LD50 intraperitoneal in mouse: 400mg/kg
MSDS Information
Provider Language
N-Methylpiperidine English
SigmaAldrich English
ACROS English
ALFA English

N-Methylpiperidine Usage And Synthesis
Description This simple piperidine derivative has been obtained from Girgensohnia diptera Bge. It is optically inactive and furnishes a crystalline picrate, m.p. 15 I-2°C and a picrolonate, m.p. 226°C.
Chemical Properties CLEAR COLOURLESS LIQUID
Uses Reactant for: ·sp3 C-H Bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines ·One-pot synthesis of Z-cinnamic acids Reactant for synthesis of: ·Unsymmetrical ureas ·Antibacterial imidazolium, pyrrolidinium, and piperidinium salts ·C1-C16 segment of goniodomin A via palladium-catalyzed organostannane thioester coupling ·Multi-targeted inhibitors of insulin-like growth factor-1 receptor and members of ErbB-family receptor kinases
Uses 1-Methylpiperidine is a reactant for sp3 C-H Bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines, One-pot synthesis of Z-cinnamic acids. It is used in the synthesis of Unsymmetrical ureas, Antibacterial imidazolium, pyrrolidinium, and piperidinium salts, C1-C16 segment of goniodomin A via palladium-catalyzed organostannane thioester coupling.
Uses Reactant for:
sp3 C-H Bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines
One-pot synthesis of Z-cinnamic acids

Reactant for synthesis of:
Unsymmetrical ureas
Antibacterial imidazolium, pyrrolidinium, and piperidinium salts
C1-C16 segment of goniodomin A via palladium-catalyzed organostannane thioester coupling
Multi-targeted inhibitors of insulin-like growth factor-1 receptor and members of ErbB-family receptor kinases
General Description A colorless liquid with the odor of pepper. Density 0.816 g / cm3 and flash point 38°F. May irritate skin and eyes. Vapors heavier than air. Used as a solvent and to make other chemicals.
Air & Water Reactions Highly flammable. Soluble in water.
Reactivity Profile N-Methylpiperidine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Health Hazard May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire Hazard Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Flammability and Explosibility Highly flammable
Safety Profile Poison by intraperitoneal and subcutaneous routes. A very dangerous fire hazard when exposed to heat or flame. When heated to decomposition it emits toxic fumes of NOx.
Toxics Screening Level The Initial Threshold Screening Level (ITSL) for n-methylpiperidine is 8 μg/m3 based on an annual averaging time.
References Jurashevskii, Stepanov,J. Gen. Chem. USSR, 9,2203 (1939)

N-Methylpiperidine Preparation Products And Raw materials
Raw materials isopropyl DL-methionate hydrochloride-->N'-methylpentane-1,5-diamine-->1-METHYL-2-PIPERIDONE-->1-METHYL-1,2,3,6-TETRAHYDROPYRIDINE-->1-Methylpyridinium chloride-->5-Amino-1-pentanol-->N-Formylpiperidine
Preparation Products Mepiquat chloride-->1-Propylpiperidine-->Mepiquat-->PIPERIDIN-1-YL-ACETIC ACID-->1-Ethylpiperidine-->1-Butyl-1-methylpiperidinium Bromide-->1-Butylpyrrolidine-->1-BUTYL-PIPERIDINE-->1-(2-CHLORO-4-NITRO-PHENYL)-PIPERIDINE