HexaMethyldisilane | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | Lyophilized Powder | CAS 1450-14-2

Hexamethyldisilane Basic information
Product Name:
Hexamethyldisilane
Synonyms:
HEXAMETHYLDISILANE;HMD;DISILANE M6;(CH3)6Si2;1,1,1,2,2,2-Hexamethyldisilane;CH7280;disilane,hexamethyl-;Hecamethyldisilane
CAS:
1450-14-2
MF:
C6H18Si2
MW:
146.38
EINECS:
215-911-0
Product Categories:
organosilicon compounds;Pharmaceutical Intermediates;Blocking Agents;Protective Agents;Chemical Synthesis;Organometallic Reagents;Standards for NMR;Silylating Agents;Special Silanes;DisilanesVapor Deposition Precursors;Organometallic Reagents;Organosilicon;Precursors by Metal;Disilanes;Analytical Chemistry;NMR Spectrometry;Si (Classes of Silicon Compounds);Silicon Compounds (for Synthesis);Si-Si Compounds;Synthetic Organic Chemistry;K00001;bc0001
Mol File:
1450-14-2.mol

Hexamethyldisilane Chemical Properties
Melting point 
9-12 °C (lit.)
Boiling point 
112-114 °C (lit.)
density 
0.715 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.422(lit.)
Fp 
29 °F
storage temp. 
Store at <= 20°C.
solubility 
sol common organic solvents; insol H2O.
form 
liquid
color 
colorless
Specific Gravity
0.729
Water Solubility 
Insoluble in water. Soluble in alcohol, ether and acetone.
Hydrolytic Sensitivity
1: no significant reaction with aqueous systems
BRN 
1633463
Stability:
Volatile
InChI
1S/C6H18Si2/c1-7(2,3)8(4,5)6/h1-6H3
InChIKey
NEXSMEBSBIABKL-UHFFFAOYSA-N
SMILES
C[Si](C)(C)[Si](C)(C)C
CAS DataBase Reference
1450-14-2(CAS DataBase Reference)
NIST Chemistry Reference
Disilane, hexamethyl-(1450-14-2)
EPA Substance Registry System
Disilane, hexamethyl- (1450-14-2)
Safety Information
Hazard Codes 
F,Xi
Risk Statements 
11-36/37-43-36/37/38
Safety Statements 
16-23-45-9-33-26-7/9
RIDADR 
UN 1993 3/PG 2
WGK Germany 
2
RTECS 
JM9170000
TSCA 
TSCA listed
HazardClass 
3
PackingGroup 
II
HS Code 
29310095
Storage Class
3 - Flammable liquids
Hazard Classifications
Eye Irrit. 2
Flam. Liq. 2
Skin Sens. 1
STOT SE 3
Toxicity
LD50 orally in Rabbit: 2160 mg/kg LD50 dermal Rabbit 2160 mg/kg

MSDS Information
Provider
Language
Hexamethyldisilane
English
ACROS
English
SigmaAldrich
English
ALFA
English
Hexamethyldisilane Usage And Synthesis
Chemical Properties
Colorless clear liquid
Uses
Hexamethyldisilane acts as a silylating reagent for allylic acetates, aryl halides and diketones. It is a source material for vapor deposition during silicon carbide growth. It is also used in electronic and semiconducter industries.
Application
Hexamethyldisilane is an important silane protective agent, which can synthesize sodium trimethylsilane, potassium trimethylsilane and lithium trimethylsilane.
Preparation of iodotrimethylsilane.
Used as trimethylsilane anion reagent.
silylating or reducing reagent in combination with a Pd catalyst or a nucleophile.
Replaces aromatic nitriles with TMS groups in presence of [RhCl(cod)]2.
Precursor for CVD of silicon carbide.
Brings about the homocoupling of arenesulfonyl chlorides in the presence of Pd2(dba)3.
Used as a solvent for the direct borylation of fluoroaromatics.
Reacts with alkynes to form siloles.
Undergoes the silylation of acid chlorides to give acylsilanes.
Preparation
Hexamethyldisilane is produced by the reaction of methyl Grignard reagent with methylchlorodisilanes. This reaction is normally conducted in the presence of an ether such as diethyl ether, ethyl propyl ether, THF and the like.
Fire Hazard
Hexamethyldisilazane (HMDZ) is a highly flammable liquid and vapour.
HMDZ liquid is lighter than water and may float on water, spreading material during fire fighting. Leaking material or fire runoff to sewer may create fire or explosion hazard.
HMDZ vapours are heavier than air and can accumulate to form explosive concentrations. The vapours may also spread a considerable distance to a source of ignition, and flash back towards the source.
HMDZ reacts with water to form ammonia.
HMDZ is a non-conductor and, therefore, can accumulate static electrical charges when processed, handled or dispensed. HMDZ's flash point is 52 to 53°F, closed cup, for "pure" material.
Purification Methods
The most likely impurity is trimethylchlorosilane (cf boiling point). Wash it with H2O, cold conc H2SO4, H2O again, then aqueous NaHCO3, dry over CaSO4 and fractionate at atmospheric pressure. [Brown & Fowles J Chem Soc 2811 1958.] A grossly impure sample (25% impurities) was purified by repeated spinning band distillation. This lowered the impurity level to 500ppm. The main impurity was identified as 1-hydroxypentamethyldisilane. [Beilstein 4 IV 4277.]
Hexamethyldisilane Preparation Products And Raw materials
Raw materials
Silane, trimethyl[4-(trimethylsilyl)butoxy]--->BUTOXYTRIMETHYLSILANE-->NONAMETHYLTRISILAZANE-->Hexamethyldisilazane
Preparation Products
2-THIENYLTRIMETHYLSILANE-->1-(Trimethylsiloxy)cyclopentene-->tert-Butoxytrimethylsilane-->Trimethyl(phenoxy)silane-->PHENYLTRIMETHYLSILANE