Efinaconazole (2R,3S) Epoxide High Purity Intermediate CAS 127000-90-2 NT

Efinaconazole (2R,3S) Epoxide (CAS 127000-90-2) is a key chiral intermediate in the synthesis of Efinaconazole, a novel triazole antifungal drug indicated for the topical treatment of onychomycosis (fungal nail infection). This compound contains an oxirane ring and a triazole moiety, which are essential structural features for the biological activity of the final API. It functions as a 14α-demethylase inhibitor, effectively blocking ergosterol biosynthesis in fungal cell membranes.

This high-purity epoxide intermediate is widely used in pharmaceutical R&D, analytical method development, and quality control applications, including ANDA filing and commercial production of Efinaconazole.

Key Features:

• High Purity: ≥ 98% (HPLC), meeting rigorous quality standards

• Key Chiral Intermediate: Essential for the synthesis of Efinaconazole API

• Analytical Grade: Suitable for use as a reference standard and impurity identification

• Regulatory Support: Can be provided with detailed characterization data compliant with regulatory guidelines

• 
  

Applications:

• Pharmaceutical Industry: As a key intermediate in the synthesis of Efinaconazole API

• Analytical R&D: For method development, method validation (AMV), and quality controlled (QC) applications

• Regulatory Filing: Used as a reference standard in ANDA and DMF submissions

Packaging: ___ (1g, 5g, 10g, 25kg per package, as per customer's request)

Storage: Store in a cool, dry, well-ventilated area, away from direct sunlight and moisture. Recommended storage temperature: 2-8°C (Refrigerator) for long-term storage