Eribulin Fragment B Alcohol Eribulin Intermediate CAS 157322-47-9 NT

Eribulin Fragment B Alcohol (CAS 157322-47-9), also known as Eribulin Related Compound 1 or Eribulin intermediate B13, is a key synthetic intermediate in the production of Eribulin Mesylate, a potent non-taxane microtubule dynamics inhibitor used for the treatment of metastatic breast cancer .

Chemical Characteristics:

• Contains a tetrahydrofuran ring with an iodinated hydroxyalkyl side chain

• Features a pivalate ester protecting group

• Multiple chiral centers with defined stereochemistry

• Molecular formula: C₂₁H₃₅IO₄ 

• Molecular weight: 478.40 g/mol 

• Boiling point: 491.8±45.0 °C (Predicted) 

• Density: 1.27±0.1 g/cm³ (Predicted) 

• Solubility: Almost insoluble in water (0.023 g/L at 25 °C) 

• pKa: 14.89±0.20 (Predicted) 

• Storage: -20°C, stored under nitrogen 

Role in Eribulin Synthesis:

Eribulin Mesylate is a synthetic analog of halichondrin B, a natural product originally isolated from the marine sponge Halichondria okadai . It functions by inhibiting microtubule dynamics, leading to cell cycle arrest and apoptosis in cancer cells . This compound is also known as Eribulin Fragment B and serves as a critical building block in the multi-step synthesis of the API, contributing to the construction of the highly complex molecular architecture required for the drug's potent biological activity .

Key Features:

• High Purity: ≥ 98% (HPLC), meeting rigorous quality standards 

• Key Intermediate: Essential for the synthesis of Eribulin Mesylate API

• Well-characterized with available analytical data

• Suitable for pharmaceutical synthesis and research applications

Applications:

• Pharmaceutical R&D: As a key intermediate in the synthesis of Eribulin Mesylate API

• Anticancer Research: Used in studies involving microtubule dynamics and breast cancer therapies

• Regulatory Submissions: Used in ANDA and DMF filings for Eribulin-related drug products

• Organic Synthesis: Complex polyether synthesis and natural product analog construction

Packaging: ___ (e.g.: 1g, 5g, 10g per package, as per customer's request)

Storage: Powder: -20°C for up to 3 years; 4°C for up to 2 years. In solvent: -80°C for 6 months; -20°C for 1 month. Protect from light and moisture. Store under nitrogen.

1. Consignee name: Mr.lucas
2. Phone/what3pp：86 15053178817
3. E mail：lucas@tf-chemi.com