N-Acetyl-3,5-diiodo-L-tyrosine CAS 1027-28-7 97% White Crystalline Powder for Pharmaceutical Intermediate & Research Use

1. Product Overview

N-Acetyl-3,5-diiodo-L-tyrosine (CAS No. 1027-28-7) is a halogenated amino acid derivative with the molecular formula C₁₁H₁₁I₂NO₄ and a molecular weight of 475.02 g/mol. It appears as a white to off-white crystalline powder and is highly valued in pharmaceutical research and fine chemical synthesis. This compound is a key intermediate in the synthesis of thyroid hormone analogs and serves as an important building block in medicinal chemistry.

Key Identifiers:

• CAS Number: 1027-28-7

• EINECS Number: 213-837-3

• MDL Number: MFCD00020004

• Molecular Formula: C₁₁H₁₁I₂NO₄

• Molecular Weight: 475.02 g/mol

2. Key Features and Advantages

• High Purity: Available at ≥97% purity, suitable for demanding research and pharmaceutical applications.

• Well-Characterized Structure: The compound features a fully acetylated L-tyrosine backbone with two iodine atoms at the 3- and 5-positions, ensuring consistent reactivity and performance.

• Excellent Stability: Stable under recommended storage conditions (−20°C), with reliable shelf life for long-term research projects.

• Versatile Reactivity: The presence of iodine substituents enables participation in various nucleophilic substitution reactions, making it a flexible intermediate in organic synthesis.

• Strict Quality Control: Each batch is tested to meet rigorous specifications, ensuring reproducibility across experiments.

3. Main Applications

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of thyroid hormone analogs, particularly triiodothyronine (T3) related compounds.

• Biochemical Research: Widely used in modeling systems to study thyroid hormone biosynthesis and enzymology.

• Enzyme Inhibition Studies: Applied in research investigating the inhibition of pepsin-catalyzed hydrolysis, helping to elucidate enzyme active site substrate-binding regions.

• Organic Synthesis: Functions as a valuable intermediate in the preparation of complex iodinated compounds and peptide-based molecules.

• Reference Standard: Used as a reference material in analytical chemistry and pharmaceutical quality control.

4. Technical Specifications

5. Storage and Handling

• Storage Conditions: Store in a cool, dry place at −20°C. Keep the container tightly sealed to prevent moisture absorption and oxidation.

• Shelf Life: When stored under recommended conditions, the product maintains its quality for extended periods.

• Handling Precautions: Handle in a well-ventilated area or fume hood. Avoid generating dust. Use appropriate personal protective equipment including gloves, safety goggles, and a lab coat.

• Packaging: Available in various sizes (1g / 5g / 25g / 100g / 1kg) with vacuum-sealed or nitrogen-flushed packaging to ensure product integrity during shipping and storage.

6. Safety Overview

• Hazard Classification: Not classified as hazardous under GHS regulations.

• Safety Statements: S22 – Do not breathe dust; S24/25 – Avoid contact with skin and eyes.

• WGK Germany: Class 3 (highly hazardous to waters).

• First Aid Measures:

• Inhalation: Move to fresh air. Seek medical attention if discomfort persists.

• Skin Contact: Remove contaminated clothing. Rinse skin thoroughly with water.

• Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present. Seek medical advice if irritation continues.

• Ingestion: Rinse mouth. Do not induce vomiting. Seek medical attention if symptoms develop.

• Firefighting: Use dry powder, foam, water spray, or carbon dioxide. Firefighters should wear self-contained breathing apparatus and full protective gear.

• Disposal: Dispose of in accordance with local, regional, and national regulations for chemical waste.