3-bromo-5-fluoroquinoline 97% CAS 1416439-00-3 Pharmaceutical Intermediate Quinoline Derivative pharmaceutical intermediate, bromo-fluoro compound, he

Product Overview

3-bromo-5-fluoroquinoline is a halogenated quinoline derivative with molecular formula C9H5BrFN and molecular weight of 226.05 g/mol. This compound features both bromine and fluorine substituents on the quinoline ring at positions 3 and 5 respectively. It serves as an important pharmaceutical intermediate in the synthesis of various bioactive molecules, particularly in the development of anti-infective agents, anti-inflammatory drugs, and anticancer therapeutics. The unique combination of bromo and fluoro substituents provides enhanced lipophilicity and metabolic stability to the resulting pharmaceutical compounds. This product is supplied with a purity of 97% and is suitable for research and development applications in pharmaceutical chemistry and organic synthesis laboratories.

Synthesis Process

The synthesis of 3-bromo-5-fluoroquinoline typically involves multi-step procedures starting from 5-fluoroquinoline or its derivatives. The bromination reaction is conducted at the 3-position of the quinoline ring using brominating agents such as N-bromosuccinimide (NBS) in appropriate organic solvents like DMF or acetonitrile under controlled temperature conditions. Alternatively, the compound can be prepared through cyclization reactions of appropriately substituted aniline derivatives with subsequent halogenation steps. The fluorination may be introduced via nucleophilic aromatic substitution or through direct fluorination methods. After the reaction, purification is achieved through column chromatography to obtain the target compound with the specified purity of 97%.

Quality Specifications

This product meets the following quality specifications: Purity (HPLC): 97% minimum; Appearance: Off-white to pale yellow powder; Loss on drying: NMT 1.0%; Residual solvents: Meets ICH guidelines; Heavy metals: NMT 10 ppm; Purity is determined by high-performance liquid chromatography (HPLC) at appropriate wavelengths. Each batch is accompanied by a certificate of analysis documenting all test results and is traceable to specific production batches.

Packaging & Storage

3-bromo-5-fluoroquinoline is packaged in amber glass bottles or plastic containers with secure closures to protect from light. Standard packaging sizes include 1g, 5g, 10g, and 25g quantities. The product should be stored in a cool, dry, and well-ventilated area away from direct sunlight and heat sources. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly closed when not in use. Handle with appropriate personal protective equipment including gloves, goggles, and lab coat. For research use only.