High Purity Epithalon Telomere Signal Freeze-Dried Lab Research Solid Reagent

  Product Detail  

Brief Overview

Core Research Application & Functional Features

1. Permitted Research Scope Only

• hTERT gene expression and telomerase activity cell culture quantitative tests
• Telomere length maintenance and replicative senescence mechanism comparative trials of somatic cell lines
• Pineal gland endocrine secretion and circadian rhythm regulatory pathway observation experiments
• Oxidative stress balance, antioxidant enzyme activation and cell survival cycle research
• Immune cell proliferative capacity and immune aging related biochemical academic projects
• Concentration gradient contrast experiments on cellular division limit (Hayflick limit) regulation
• Neuroendocrine aging, premature senescence cell model and epigenetic modification research
• Antioxidative damage and chromosome stability comparative lab observation of long-cycle cell culture

2. Unique Research Advantages

1. Specific Telomere Regulatory Signal Activation
   
   
   The short linear molecular structure can penetrate cell membrane and interact with nuclear transcriptional regulatory elements, stably upregulate hTERT related downstream signal pathways inside test carriers. It provides single-variable clear data for telomere biology and senescence related lab tests, avoiding multi-factor interference to experimental results, ideal for controlled comparative cell culture models.
2. Superior Freeze-Dried Long-Term Activity Stability
   
   
   Low-temperature vacuum dehydration locks complete linear molecular frame without amino acid chain fracture or decomposition during storage and transportation. It effectively solves the activity attenuation defect of liquid medium samples, greatly reducing frequent re-preparation workload for long-period lab inventory management and long-cycle cell passaging experiments.
3. Wide Compatibility With Standard Cell Culture Systems
   
   
   This solid can fully blend with lab bacteriostatic purified water and PBS buffer liquid, compatible with most conventional mammalian fibroblast, lymphocyte, pineal tissue slice and epithelial cell test systems, without introducing extra interfering impurities to cell culture environment.
4. Distinct Concentration Gradient Experimental Response
   
   
   Adjustable working concentration fits diversified lab design; telomerase activity, telomere length and antioxidant indicators show regular gradient changes under different addition dosages, convenient for quantitative data statistics and academic paper result analysis of biogerontology research.
5. Ultra-Low Impurity Interference Profile
   
   
   Multi-stage precise purification workflow minimizes truncated amino acid fragments, deamidation residues and incomplete synthesis by-products inside finished solid. It will not generate extra noise signals in spectrophotometry, fluorescence detection and telomere length quantitative testing equipment, ensuring high-definition output of biochemical test data.
6. Uniform Batch-to-Batch Consistency
   
   
   Standardized Fmoc solid-phase synthesis, purification and freeze-drying production workflow ensures identical purity, dissolving performance and telomere regulatory signal activity across all production lots. No test result deviation caused by inconsistent raw material quality, fully fit for parallel comparison experiments and repeated result verification of senescence research groups.

Complete Standard Specification Parameters

Basic Product Identification Info

• Full Product Name: Epithalon Telomere Regulatory Signal Molecular Solid
• Alias: Pineal Gland Derived Senescence Research Reagent
• CAS Reference Number: 307297-39-8
• Amino Acid Sequence: L-Ala-L-Glu-L-Asp-Gly (AEDG)
• Molecular Formula: C₁₄H₂₂N₄O₉
• Theoretical Molecular Weight: 390.35 Da
• Theoretical Isoelectric Point: 3.16
• Visual Form: Uniform white freeze-dried solid, free of clumps, discoloration, tiny foreign particles or visible impurities
• Odor Characteristic: Completely odorless
• Dissolving Performance: Fully blendable with lab bacteriostatic purified water and PBS buffer liquid; cannot mix with alcohol-based lab liquid medium; solubility ≥250mg/mL in aqueous medium
• Post-dissolving Liquid State: Clear colorless transparent solution without suspended particles, turbidity or precipitate after full dissolution
• pH Value of 1mg/mL Mixed Liquid: 3.0 ~ 5.5
• Residual Moisture Content Test Index: ≤ 2.0% (tested via Karl Fischer titration method per batch)
• Endotoxin Level: < 0.1 EU/mg, fully comply with global universal safety standards for cell and animal lab research
• Heavy Element Residue Control Limit: Lead ≤10ppm, Arsenic ≤2ppm, Cadmium ≤1ppm, Mercury ≤1ppm
• Microbe Control Standard: Total aerobic microbes <10 CFU/mg, yeast and mold <5 CFU/mg; zero harmful pathogenic bacteria detected in all batches
• Molecular Frame Integrity: Spectrum matching test carried out for every batch to confirm complete intact amino acid chain without fracture or deamidation modification defects

Available Sealed Vial Sizes (No bulk kilogram supply)

• EPI-10: 10mg freeze-dried telomere signal solid per vacuum-sealed neutral glass vial
• EPI-50: 50mg freeze-dried telomere signal solid per vacuum-sealed neutral glass vial

Strict Production & Inspection Quality Control Standards

1. Core High Purity Benchmark
   
   
   Guaranteed HPLC chromatographic purity of finished telomere signal solid ≥99.0%. Complete spectrum chromatogram records are attached to each batch test report. Single unknown individual impurity ≤ 0.3%, total combined unknown impurities ≤ 1.0%. Testing adopts C18 reverse-phase chromatographic column with 220nm UV wavelength detection for precise purity numerical measurement, separately verifying amino acid chain integrity and absence of deamidation by-products.
2. Mandatory Full Batch Testing Items

• Spectrum molecular weight matching test, ensuring measured molecular weight error within ±5 Da compared with theoretical standard value
• Full linear amino acid chain structural verification to confirm complete matching with standard Epithalon molecular configuration
• Trace residual substance testing following ICH Q3C standardized limits
• Constant temperature & humidity accelerated stability test for shelf life effectiveness validation
• Telomerase regulatory biological activity detection to lock stable and consistent lab research performance
• 100% manual visual full inspection of all finished sealed vials before shipment to screen out defective goods
• Complete batch full traceability management system covering raw material incoming records, Fmoc synthesis production operation logs, full-item inspection data and outgoing delivery archive files

Standard Step-by-Step Dissolving Operation Guidance

Recommended Matching Liquid Medium: Lab dedicated bacteriostatic purified water

1. Slowly pour bacteriostatic purified water along the inner wall of the glass vial to avoid massive foaming generation
2. Fully tighten the vial cap, rotate and swirl gently in circular motion until all freeze-dried solid material dissolves completely
3. Do not shake the vial violently; fierce agitation will break short linear amino acid chain structure and weaken stable telomere regulatory signal activity

Storage Environment & Valid Usage Period Rules

Unopened Original Vacuum-Sealed Vials

• Long-term storage environmental condition: Keep fully sealed vials stored at -20°C ~ -80°C, completely shielded from direct light and high moisture
• Valid storage duration under constant -20°C freezing environment: 12 months
• Valid storage duration under constant -80°C ultra-low temperature environment: 36 months
• Short transit stability tolerance: Maintain stable telomere regulatory signal activity for up to 7 days under ambient temperature below 25°C
• Forbidden storage behavior: Frequent repeated temperature fluctuation, long-time direct sunlight exposure

Liquid Mixed With Bacteriostatic Purified Water

• Storage condition after dissolution: Place inside refrigerator under 2°C ~ 8°C refrigeration environment, fully shaded
• Suggested full usage time limit: Consume all mixed liquid within 14 days after preparation completion
• Strict prohibition: Do not freeze diluted mixed liquid; repeated freezing and thawing cycles will permanently damage short amino acid chain molecular stability and lose telomere research signal activity

Shipping & Receiving Handling Reminders

1. Small trial vial orders can be delivered via standard international express for short-distance cross-border transit
2. Large quantity multi-vial orders are strongly suggested to choose temperature-insulated protective packaging to maintain stable molecular state during long-distance overseas transportation
3. Complete supporting shipping documents will be delivered together with all parcels, including unified technical data sheets and batch exclusive test records for customs inspection and internal lab filing use

Lab Operation Safety Reminders

1. Wear disposable nitrile protective gloves, transparent safety goggles and dust-proof lab masks during powder weighing and dissolving operating procedures
2. Avoid direct skin contact, eye contact and inhalation of dry freeze-dried telomere signal solid powder
3. In case of accidental contact with skin or eye tissue, flush the affected area thoroughly with plenty of clean running water immediately
4. Dispose of residual solid powder and waste mixed liquid strictly following internal waste management rules of your laboratory; do not pour residual liquid directly into domestic drainage pipelines or general household waste bins

Important Usage Restriction Statement

Free Supporting Technical Documents Provided For All Orders

1. Batch exclusive test report with full HPLC spectrum purity test data records
2. Full-version unified technical data sheet covering all specifications, dissolving operation steps and standard storage rules
3. Complete molecular structure schematic diagram and amino acid chain structural verification file
4. Full inspection records of heavy element, endotoxin and microbe testing indexes
5. Original raw data of long-term molecular stability accelerated testing
   
   
   Customized lab dedicated experiment operation guidance documents can be provided upon customer request for institutional internal research archive sorting and lab safety training use.
6.