2,2-Dicyano-1,1-biphenyl-4,4-dicarboxylic acid CAS 1052137-51-5 High Purity 97% MOF COF Ligand Pharmaceutical Intermediate

1. Product Overview

2,2'-Dicyano-[1,1'-biphenyl]-4,4'-dicarboxylic acid (CAS: 1052137-51-5) is a dicyano-substituted biphenyl derivative featuring two carboxylic acid functional groups. With the molecular formula C16H8N2O4 and a molecular weight of 292.25 g/mol, this compound serves as a versatile organic building block. It is widely recognized as a key ligand in the construction of metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), as well as an important intermediate in pharmaceutical research and advanced material development.

2. Key Features and Advantages

• Dual Functional Groups: Incorporates both cyano (-CN) and carboxylic acid (-COOH) moieties, enabling multi-directional coordination chemistry and versatile reactivity in organic synthesis.

• High Purity Available: Offered at purity levels of 97% (HPLC), ensuring reliable and reproducible results in research and industrial applications.

• MOF COF Compatibility: Specifically designed as a linker molecule for reticular synthesis, allowing precise control over framework topology, pore metrics, and functionality.

• Stable Physicochemical Profile: Exhibits a predicted density of 1.53 plus or minus 0.1 g/cm3 and a high predicted boiling point of 610.6 plus or minus 55.0 degrees Celsius, indicating good thermal stability.

• Well-Characterized: Comprehensive analytical data available, including H1 NMR, HPLC, and GC reports to support quality assurance.

3. Main Applications

• Metal Organic Frameworks (MOFs): Acts as a critical organic linker in the synthesis of crystalline MOFs for gas storage, separation, and catalysis applications.

• COF Ligand: Serves as a building block in the preparation of covalent organic frameworks for applications in energy storage, photocatalysis, and molecular sieving.

• Pharmaceutical Research: Functions as a valuable intermediate in drug discovery and medicinal chemistry, contributing to the development of novel therapeutic agents.

• Advanced Material Synthesis: Used in the preparation of functional materials requiring rigid, conjugated biphenyl architectures with tailored porosity and surface properties.

• Academic Research: A widely referenced compound in published literature focusing on reticular chemistry and porous material science.

4. Technical Specifications

5. Storage and Handling

Store in a cool, dry, and well-ventilated area away from direct sunlight and moisture. Keep the container tightly sealed when not in use to prevent contamination and moisture absorption. Recommended storage temperature is 2 to 8 degrees Celsius for long-term preservation, while room temperature storage is acceptable for short-term use. Handle with standard laboratory precautions. Use appropriate personal protective equipment including gloves, safety goggles, and a lab coat. Avoid inhalation of dust and contact with skin or eyes. Refer to the Safety Data Sheet (SDS) for comprehensive handling instructions.

6. Safety Overview

This product is intended for research and industrial use only and is not for direct human consumption or medical application. It may cause irritation to the eyes, skin, and respiratory tract. Handle in accordance with good laboratory practices. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Dispose of in accordance with local, regional, and national regulations for chemical waste. Users are advised to read the full Safety Data Sheet (SDS) prior to use. For any inquiries regarding safety or regulatory compliance, please contact our technical support team.