Chlorfenapyr

407.61300

407.61

602-782-4

NWI20P05EB

DTXSID9032533

Light tan or light yellow powdered solid|White solid

37.95000

5.45548

off-white to light brown powder with an halide odor

1.53 g/cm3

100.5 °C

443.5ºC at 760 mmHg

222ºC

1.559

Solubities in water at 25 deg C. Solvent Solubility Deionized water 0.12 mg/ml Water, pH 4 0.13 mg/L Water, pH 7 0.14 mg/L Water, pH 10 0.12 mg/L

0-6ºC

4.6E-08mmHg at 25°C

LD50 (single dose) in male, female rats (mg/kg): 223, 459 orally; in rabbits: >2000 dermally (Lovell); LC50 in Japanese carp: 0.5 ppm (Lovell)

Not explosive

Characteristic of halides and ketones

pH = 7.16; 1% aqueous slurry at 24 °C

Henry's Law constant = 5.73X10-9 atm-cu m/mol at 25 °C (est)

190.4 Ų [M+HCOO]-

Hydroxyl radical reaction rate constant = 1.35X10-11 cu cm/molec-sec at 25 °C (est)

UN 2811

3

R22; R23; R50/53

S13-S36/37-S45-S60-S61

T

P261-P273-P304 + P340 + P312-P391-P403 + P233-P501

H302-H331-H410

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.|Do not contaminate water, food, or feed by disposal.|Safe Disposal of Pesticides. The best way to dispose of small amounts of excess pesticides is to use them - apply them - according to the directions on the label. If you cannot use them, ask your neighbors whether they have a similar pest control problem and can use them. If all of the remaining pesticide cannot be properly used, check with your local solid waste management authority, environmental agency, or health department to find out whether your community has a household hazardous waste collection program or a similar program for getting rid of unwanted, leftover pesticides. These authorities can also inform you of any local requirements for pesticide waste disposal.|Safe Disposal of Pesticides. An empty pesticide container can be as hazardous as a full one because of residues left inside. Never reuse such a container. When empty, a pesticide container should be rinsed carefully three times and the rinsewater thoroughly drained back onto the sprayer or the container previously used to mix the pesticide. Use the rinsewater as a pesticide, following label directions. Replace the cap or closure securely. Dispose of the container according to label instructions. Do not puncture or burn a pressurized container like an aerosol - it could explode. Do cut or puncture other empty pesticide containers made of metal or plastic to prevent someone from reusing them. Wrap the empty container and put it in the trash after you have rinsed it.

|Danger|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P273, P301+P312, P304+P340, P311, P321, P330, P391, P403+P233, P405, and P501|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|Aggregated GHS information provided by 224 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P260, P261, P264, P270, P271, P301+P312, P304+P340, P305+P351+P338, P309+P311, P311, P314, P321, P330, P337+P313, P403+P233, P405, and P501

Chemical-resistant apron when cleaning equipment, mixing, or loading. Chemical resistant gloves.

Not explosive

Use water, alcohol foam, dry chemical, or carbon dioxide to extinguish fires.

If a spill occurs, clean it up promptly. Don't wash it away. Instead, sprinkle the spill with sawdust, vermiculite, or kitty litter. Sweep it into a plastic garbage bag, and dispose of it as directed on the pesticide product label.|After Applying a Pesticide, Indoors or Outdoors. To remove pesticide residues, use a bucket to rinse tools or equipment three times, including any containers or utensils that you used when mixing the pesticide. Then pour the rinsewater into the pesticide sprayer and reuse the solution by applying it according to the pesticide product label directions. After applying any pesticide wash your hands and any other parts of your body that may have come in contact with the pesticide..To prevent tracking pesticides inside, remove or rinse your boots or shoes before entering your home. Wash any clothes that have been exposed to a lot of pesticide separately from your regular wash.

Do not get in eyes, on skin, or clothing. Avoid breathing vapor or mist. Harmful if inhaled. Wash thoroughly after handling with soap and water.|Wear the items of protective clothing the label requires: for example, non-absorbent gloves (not leather or fabric), rubber footwear (not canvas or leather), a hat, goggles, or a dust-mist filter. If no specific clothing is listed, gloves, long-sleeved shirts and long pants, and closed shoes are recommended. You can buy protective clothing and equipment at hardware stores or building supply stores.|Indoor Applications. If the label directions permit, leave all windows open and fans operating after the application is completed. If the pesticide product is only effective in an unventilated (sealed) room or house, do not stay there. Put all pets outdoors, and take yourself any your family away from treated areas for at least the length of time prescribed on the label. Apply most surface sprays only to limited areas such as cracks; don't treat entire floors, walls, or ceilings. Don't let pesticides get on any surfaces that are used for food preparation. Wash any surfaces that may have pesticide residue before placing food on them.|Outdoor Applications. Never apply pesticides outdoors on a windy day (winds higher than 10 mph). Position yourself so that a light breeze does not blow pesticide spray or dust into your face.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Poisonous solid, organic, NOS; Toxic solid, organic, NOS (Chlorfenapyr)/|/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. /Poisonous solid, organic, NOS; Toxic solid, organic, NOS (Chlorfenapyr)/|/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Poisonous solid, organic, NOS; Toxic solid, organic, NOS (Chlorfenapyr)/|/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Poisonous solid, organic, NOS; Toxic solid, organic, NOS (Chlorfenapyr)/|For more DOT Emergency Guidelines (Complete) data for CHLORFENAPYR (8 total), please visit the HSDB record page.

Chlorfenapyr is a moderate but reversible eye irritant, but not a skin irritant.

Inhibition of /microsomal/ oxidative activation /of chlorfenapyr/ ... in insects in vivo with piperonyl butoxide antagonizes the toxicity of chlorfenapyr.

LD50 Rat (male) oral 441 mg/kg /from table/|LD50 Rat (female) oral 1152 mg/kg /from table/|LD50 Mouse (male) oral 45 mg/kg /from table/|LD50 Mouse (female) oral 78 mg/kg /from table/|For more Non-Human Toxicity Values (Complete) data for CHLORFENAPYR (8 total), please visit the HSDB record page.

/BIRDS and MAMMALS/ The acute toxicity of chlorfenapyr to birds is high to very high. The subchronic toxicity to birds is also very high (eg, in mallard ducks, chlorfenapyr at 2.5 ppm in the diet reduced adult body weights and decr egg-laying and hatch rates by about 40 to 60%) ... Although /lab/ results suggest that there is a considerable potential for the use of chlorfenapyr to cause acute and reproductive toxicity in wild birds, there appear to be no reports of detectable impacts on birds or other wildlife when these have been closely monitored in areas where chlorfenapyr has been used.|/AQUATIC SPECIES/ Chlorfenapyr is also very highly toxic to fish and aquatic invertebrates /with LC50 for fish ranged 7.4 to 500 ppb/24 to 96 hr/ ...|/BIRDS and MAMMALS/ Clinical signs of intoxication /in acute studies/ common to all three species included whole body and wing beat convulsions, lethargy and loose green or chalky excreta. In addition, dyspnea (labored breathing) and opisthotonos (head stretched over back) were reported for the mallard. Lethargy was reported in the highest red-winged blackbird dose group. Post-mortem exam showed no treatment related abnormalities other than firm pectoral muscles. A reduction in body weight, as compared to the control animals, occurred in the northern bobwhite at dose levels above 32 mg/kg during the first 3 days of the study. No body weight reduction was noted in the mallards or red-winged blackbirds. A reduction in food consumption, as compared to the control animals, occurred in the northern bobwhite at dose levels above 16 mg/kg during the first 3 days of the study. A similar response was observed in the mallard at treatments higher than 4 mg/kg. These results indicate that chlorfenapyr is very highly toxic to waterfowl and passerine species and highly toxic to upland gamebirds on an acute oral basis.|/BIRDS and MAMMALS/ AC 303,268, a soil photolytic degradate, was shown to kill nearly as quickly as the parent compound and was more toxic to northern bobwhite. Deaths prior to day 4 accounted for 88% of the total mortality observed in mallards and northern bobwhite. Weight loss coincided with decreased food consumption at day 3 at treatment groups 40 mg/kg and higher in the mallard and at 25 mg/kg and higher in the northern bobwhite. Signs of intoxication common to both species included shallow rapid breathing, reduced reaction time, and loss of coordination. Necropsy showed small pale yellow spleens and stained vents. /AC 303,268; soil degradate/|For more Ecotoxicity Excerpts (Complete) data for CHLORFENAPYR (9 total), please visit the HSDB record page.

Chlorfenapyr's production may result in its release to the environment through various waste streams; it's use as an insecticide and an acaricide(1) will result in its direct release to the environment(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 10,000(SRC), determined from a log Kow of 4.83(2) and a regression-derived equation(3), indicates that chlorfenapyr is expected to be immobile in soil(SRC). Volatilization of chlorfenapyr from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.7X10-9 atm-cu m/mole(SRC), using a fragment constant estimation method(4). Chlorfenapyr is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 7.4X10-8 mm Hg(SRC), determined from a fragment constant method(5). A biodegradation half-life range of 230-250 days in soil(6) suggest that biodegradation is not an important environmental fate process in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10,000(SRC), determined from a log Kow of 4.83(2) and a regression-derived equation(3), indicates that chlorfenapyr is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 5.7X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). BCFs of 83-114 given for bluegill sunfish(5), suggest the potential for bioconcentration in aquatic organisms is moderate to high(SRC). Photolysis is expected to be the principal fate of chlorfenapyr in water(5). A biodegradation half-life of 250 days in sediment(5) suggest that biodegradation is not an important environmental fate process in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), chlorfenapyr, which has an estimated vapor pressure of 7.4X10-8 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase chlorfenapyr is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1.2 days(SRC), calculated from its rate constant of 1.4X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase chlorfenapyr may be removed from the air by wet or dry deposition(SRC). Chlorfenapyr photodegrades in sterile fresh water with a half-life of 5-7 days(4), suggesting that photolysis in air may be important(SRC).

The rate constant for the vapor-phase reaction of chlorfenapyr with photochemically-produced hydroxyl radicals has been estimated as 1.4X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 1.2 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Hydrolysis of chlorfenapyr is not expected to be environmentally relevant given a half-life of >30 days(2). Chlorfenapyr photodegrades in sterile fresh water with a half-life of 5-7 days(2).

BCFs of 83-114 are given for bluegill sunfish with a duration half-life of 3-4 days(1). According to a classification scheme(2), this BCF range suggests the potential for bioconcentration in aquatic organisms is moderate to high(SRC).

The Koc of chlorfenapyr is estimated as 10,000(SRC), using a log Kow of 4.83(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that chlorfenapyr is expected to be immobile in soil.

The Henry's Law constant for chlorfenapyr is estimated as 5.7X10-9 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that chlorfenapyr is expected to be essentially nonvolatile from water surfaces(2). Chlorfenapyr's Henry's Law constant indicates that volatilization from moist soil surfaces is not expected(SRC). Chlorfenapyr is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 7.4X10-8 mm Hg(SRC), determined from a fragment constant method(3).

Chlorfenapyr was detected in 10 of 129 sweet peppers tested, at concentrations of <0.5 ug/g, sampled from Hyogo Prefecture, Japan(1).

Occupational exposure to chlorfenapyr may occur through dermal contact with this compound at workplaces where chlorfenapyr is produced or used. The general population may be exposed to chlorfenapyr via ingestion of food and dermal contact with this compound near fields where chlorfenapyr is applied. (SRC)

An oral dose of chlorfenapyr was poorly absorbed in rats and over 80% was eliminated in the feces ...|Radioactive chlorfenapyr was administered to rats by oral gavage at dose levels of 20 mg/kg/day as a single dose or following a 14-day pre-treatment with non-radioactive chlorfenapyr, or at 200 mg/kg as a single dose. Based on the metabolites identified, the major deposition route of orally administered chlorfenapyr is fecal excretion of unaltered parent compound. The two rings of the molecule are not cleaved. Metabolites are excreted primarily in urine; accumulation in tissues is minimal.

Chlorfenapyr shows virtually no uncoupling activity but removal of the N-ethoxymethyl group through microsomal oxidation releases the corresponding free pyrrole (AC 303,268) which is a lipophilic weak acid with very strong uncoupling activity ... AC 302,268 has an acute toxicity higher than that of chlorfenapyr in both vertebrates and insects (eg, the acute oral LD50 for the rat is 29 mg/kg). Upon injection into insects it cause an almost immediate and massive stimulation of respiration whereas the parent chlorfenapyr does so only after a significant delay. All these observations support the idea that chlorfenapyr is a proinsecticide and requires metabolic conversion to the active uncoupler, AC 303,268, before it exert a toxic action.|[2-Pyrrole-14C]CL 303,630 or [Phenyl-(U)-14C]CL 303,630 (radiochemical,purity: 99-100%, S.A. 134.7 uCi/mg and 411.4 uCi/mg, respectively) and nonlabeled CL 303,630 (...98.8% purity) were suspended in 0.5% (w/w) CMC solution and administered via gavage to 5 rats/sex as single doses of 20.7 or 206.7 mg/kg and as multiple oral doses: pretreat 5 rats/sex daily with nonlabeled CL 303,630 for 14 days prior to pulsing with 20.5 mg/kg [2-Pyrrole-14C]CL 303,630 or [Phenyl-(U)-14C]CL 303,630. Regardless of treatment regimen, 14C CL 303,630 was eliminated mainly by the fecal route. By 48 hours, 70.4-91.4% and 3.9-9.7% of the administered radioactivity was detected in feces and urine, respectively. Blood and tissue concentrations were higher in females than in males indicating that there are substantial sex-related differences. The excreted fecal residue was mainly unchanged parent compound plus minor N-dealkylated, debrominated, and hydroxylated oxidation products. Absorbed CL 303,630 was extensively metabolized in tissues and urine by N-dealkylation, debromination, ring hydroxylation, and conjugation.|AC 303,268, and its further degradation products, is a common metabolites of chlorfenapyr found in studies with vertebrates ... Urinary metabolites /from an oral dose admin in rats/ included products of N-alkoxy side chain oxidation and removal (eg, AC 303,268) and ring hydroxylation products and their conjugates. Similar results were obtained with goats and hens. In fish and soil, debromination is observed as an additional metabolic route.

Chlorfenapyr shows virtually no uncoupling activity but removal of the N-ethoxymethyl group through microsomal oxidation releases the corresponding free pyrrole (AC 303,268) which is a lipophilic weak acid with very strong uncoupling activity ...|Chlorfenapyr is a member of a new class of chemicals- the pyrroles. The compound is a pro-insecticide, i.e. the biological activity depends on its activation to another chemical. Oxidative removal of the N-ethoxymethyl group of chlorfenapyr by mixed function oxidases forms the compound CL 303268. CL 303268 uncouples oxidative phosphorylation at the mitochondria, resulting in disruption of production of ATP, cellular death, and ultimately organism mortality.

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

/SIGNS AND SYMPTOMS/ Chlorfenapyr is a moderate but reversible eye irritant, but not a skin irritant.|/ALTERNATIVE and IN VITRO TESTS/ The estrogenic activities of 32 pesticides in agricultural products were evaluated using the E-CALUX assay system developed by Xenobiotic Detection Systems Inc (North Carolina, USA). This system utilizes human ovarian carcinoma cells (BG1) stably transfected with an estrogen-responsive luciferase reporter gene plasmid. ... Chlorfenapyr had anti-estrogenic activity. ...

AC 303630

Trade names include Alert, Citrex, Intrepid, Phantom, Pirate, Stalker, and Sunfire.|Trade Name: Pylon Miticide-Insecticide 21.4% chlorfenapyr|Suspension concentrate.

The WHO Recommended Classification of Pesticides by Hazard identifies Chlorfenapyr (technical grade) as Class II: moderately hazardous; Main Use: insecticide, miticide.|Chlorfenapyr ... was developed by structural modification of a microbial natural product, dioxapyrrolomycin ...

Product by glc. Residues by hplc

Agrochemicals -> Acaricides, Insecticides