—— Product Specifications ——

—— Product Detail ——

Product Overview

1-Cbz-3-(Aminomethyl)-3-hydroxypyrrolidine is a protected amino alcohol compound featuring both a Cbz (benzyloxycarbonyl) protecting group on the nitrogen atom and a hydroxyl group at the 3-position of the pyrrolidine ring. This unique structure makes it a valuable building block in modern organic synthesis, particularly in the preparation of peptidomimetics and constrained amino acid derivatives. The combination of an amino methyl group and a tertiary hydroxyl group at the same carbon center provides specific reactivity profiles for selective chemical transformations. This compound is widely utilized in the synthesis of pharmaceutical candidates, especially those targeting neurological disorders and metabolic diseases. The Cbz protecting group can be conveniently removed under mild hydrogenolysis conditions, allowing for further elaboration of the molecule. As a specialized fine chemical, it serves as a critical intermediate in the development of novel therapeutic agents and research chemicals.

Synthesis Process

The synthesis of 1-Cbz-3-(Aminomethyl)-3-hydroxypyrrolidine typically involves the cyclization of a suitably functionalized precursor followed by protection with benzyl chloroformate. The key step involves the construction of the 3,3-disubstituted pyrrolidine ring system through intramolecular cyclization. The amino group is introduced via nucleophilic substitution or reductive amination, while the hydroxyl functionality is introduced through appropriate oxidation or addition reactions. After cyclization, the nitrogen atom is protected with a Cbz group using benzyl chloroformate under basic conditions. The final product is purified through column chromatography to achieve pharmaceutical-grade purity. Quality control is performed using HPLC, NMR spectroscopy, and mass spectrometry to ensure structural integrity and purity.

Quality Specifications

Our 1-Cbz-3-(Aminomethyl)-3-hydroxypyrrolidine meets stringent pharmaceutical grade specifications with a minimum purity of 95% as determined by HPLC. The product is characterized by specific optical rotation within the expected range. Residual solvents comply with ICH guidelines, and heavy metal content is limited to below 10 ppm. Water content is maintained below 1.0% to ensure chemical stability. Each batch comes with a Certificate of Analysis (COA) including HPLC, 1H-NMR, 13C-NMR, and mass spectrometry data. The product is tested for related substances with total impurities not exceeding 5.0%.

Packaging & Storage

1-Cbz-3-(Aminomethyl)-3-hydroxypyrrolidine should be stored in a cool, dry, and well-ventilated area away from direct sunlight and heat sources. Recommended storage temperature is 2-8°C. The product should be kept in tightly sealed original containers. For laboratory use, amber glass bottles or plastic containers are recommended. For bulk quantities, nitrogen-filled containers or vacuum-sealed packaging is advised to prevent moisture absorption and oxidation. Shelf life under proper storage conditions is 24 months. Handle with appropriate personal protective equipment including gloves, safety goggles, and lab coat.

—— C ompany Profile ——

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

—— Q&A ——

Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

Q4: What is your MOQ? Is there a discount?
A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.

Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.