—— Product Specifications ——

—— Product Detail ——

Product Overview

AZD3988 is a potent and selective TGR5 (Takeda G-protein coupled receptor 5) agonist developed by AstraZeneca. TGR5 is a membrane-bound receptor widely expressed in various tissues including liver, intestine, and immune cells. This receptor plays a crucial role in regulating glucose metabolism, lipid metabolism, and inflammatory responses. AZD3988 represents a novel therapeutic approach for metabolic disorders and inflammatory conditions. The compound has been investigated for its potential in treating type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), and inflammatory bowel disease. With a purity of 98%, this pharmaceutical intermediate meets the stringent quality requirements for drug development and clinical research applications. AZD3988 belongs to a class of compounds that activate TGR5 signaling pathways, leading to improved insulin sensitivity and reduced inflammation.

Synthesis Process

The synthesis of AZD3988 involves a multi-step organic synthesis process. The key steps include the construction of the core heterocyclic scaffold through a Suzuki coupling reaction, followed by functional group transformations to introduce the necessary substituents. The process utilizes palladium-catalyzed cross-coupling reactions for carbon-carbon bond formation. Protecting group strategies are employed to ensure chemoselectivity. The final step involves deprotection and purification by column chromatography to achieve the target compound with high purity. All starting materials are carefully selected to meet pharmaceutical quality standards, and the synthesis is conducted under controlled conditions to ensure reproducibility and quality consistency.

Quality Specifications

AZD3988 is manufactured to meet pharmaceutical grade specifications with a minimum purity of 98% as determined by HPLC. The product undergoes comprehensive quality control testing including HPLC purity analysis, NMR spectroscopy for structural confirmation, mass spectrometry for molecular weight verification, and moisture content analysis. Impurity profiling is performed to identify and quantify individual impurities. Residual solvents are controlled within acceptable limits according to ICH guidelines. Each batch comes with a Certificate of Analysis documenting all test results. The product is tested for microbial limits and heavy metals to ensure safety for pharmaceutical applications.

Packaging & Storage

AZD3988 should be stored in a cool, dry place away from direct sunlight and moisture. The recommended storage temperature is 2-8°C. Keep the container tightly sealed when not in use. Handle under inert atmosphere if possible to prevent degradation. Transport in accordance with dangerous goods regulations. The product has a shelf life of 24 months when stored under recommended conditions. Proper PPE including gloves, goggles, and lab coat should be worn when handling this compound.

— C ompany Profile ——

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

—— Q&A ——

Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

Q4: What is your MOQ? Is there a discount?
A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.

Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.