—— Product Specifications ——

—— Product Detail ——

Product Overview

GPR132 antagonist 1 (NOX-6-18) is a highly selective antagonist targeting the G protein-coupled receptor 132 (GPR132), also known as G2A receptor. GPR132 is expressed in various tissues including immune cells, neurons, and cancer cells, playing important roles in cell proliferation, migration, and immune response regulation. This compound is specifically designed for scientific research and pharmaceutical development applications. With a purity of 98% or higher, it provides reliable performance in experimental settings. NOX-6-18 has shown significant potential in studying GPR132-mediated signaling pathways and may contribute to the development of novel therapeutic agents for inflammatory diseases, cancer, and metabolic disorders.

Synthesis Process

The synthesis of GPR132 antagonist 1 (NOX-6-18) involves a multi-step organic synthesis process. The process typically starts from commercially available building blocks, followed by amide coupling reactions, Suzuki-Miyaura cross-coupling, and final purification through preparative HPLC. The synthetic route is optimized to ensure high yield and purity while minimizing impurities. Key steps include the formation of the core heterocyclic structure and the introduction of specific functional groups that confer antagonist activity. Quality control is implemented at each stage to ensure consistency and purity.

Quality Specifications

This product meets the following specifications: purity ≥98% (HPLC), moisture content <1%, residual solvents comply with ICH guidelines, and heavy metals <10ppm. Each batch is accompanied by a Certificate of Analysis (COA) including HPLC, NMR, and Mass Spectrometry data. The product is tested for identity, purity, and stability before release. Storage conditions and expiration date are clearly indicated on product labels and accompanying documentation.

Packaging & Storage

The product is packaged in high-quality amber glass vials or foil-sealed plastic containers to protect from light and moisture. Primary packaging includes desiccant packs to maintain dryness. Storage recommendations: store at -20°C in a dry, dark environment. Keep container tightly closed when not in use. For long-term storage, maintain at -80°C under inert atmosphere. Avoid repeated freeze-thaw cycles. Handle under inert atmosphere when opening to prevent moisture absorption.

—— C ompany Profile ——

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

—— Q&A ——

Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

Q4: What is your MOQ? Is there a discount?
A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.

Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.