—— Product Specifications ——
—— Product Detail ——
1. Product Overview
2-Isopropoxybenzamide (2-Isopropoxybenzamide) is a typical benzamide derivative, usually appearing as a white to off-white crystalline powder with stable properties at room temperature. With a purity of ≥98%, this product is a research-grade special intermediate for organic synthesis and an important structural building block in the field of fine chemicals.
The molecule contains both an amide bond and an isopropoxy substituent, providing excellent reactivity and structural modification potential. It is widely used in new drug R&D, synthesis of organic functional molecules and fundamental research in materials chemistry. Not for clinical diagnosis, food additives or household daily use.
2. Synthetic Process
The classic synthetic route of 2-isopropoxybenzamide uses 2-hydroxybenzamide as the starting material, with key steps as follows:
- Nucleophilic substitution reaction between 2-hydroxybenzamide and 2-bromopropane under the action of an alkaline acid-binding agent (such as potassium carbonate, sodium carbonate) to introduce the isopropoxy group;
- The reaction is refluxed in a polar aprotic solvent (such as DMF, acetone) to promote ether bond formation;
- After completion of the reaction, the mixture is cooled, extracted and washed with water to remove salts, and the organic phase is concentrated to obtain the crude product;
- High-purity target product is finally obtained through purification by recrystallization (ethanol/water system) or column chromatography.
The whole process features mild conditions, short route and good atom economy, suitable for laboratory scale-up and kilogram-level industrial preparation.
3. Mechanism of Action
As an organic synthesis building block, 2-isopropoxybenzamide itself has no direct pharmacological activity, and its value lies in the participation of its structural units in subsequent reactions:
- The amide bond (-CONH₂) can undergo hydrolysis, reduction, condensation, cyclization and other reactions to construct core skeletons such as pyrimidine, quinazoline and benzoheterocycles;
- The isopropoxy group on the benzene ring is an electron-donating substituent, which can regulate the molecular electron cloud density and improve the selectivity of subsequent electrophilic substitution reactions;
- In drug molecular design, it is often introduced into target molecules as a benzamide pharmacophore fragment for the construction of receptor antagonists, enzyme inhibitors and other candidate compounds;
- It can also act as a ligand unit to participate in the synthesis of metal complexes for catalytic systems or functional material research.
4. Quality Specifications
- Appearance: White to off-white crystalline powder
- Purity: ≥98% (HPLC area normalization method)
- Moisture: ≤0.5%
- Melting Point: Complies with standard characteristic range
- Residue on Ignition: ≤0.2%
- Heavy Metals: ≤20 ppm
- Volatile Impurities: Comply with research-grade internal control standards
- Identification: Consistent structure confirmed by HPLC, ¹H-NMR
5. Packaging and Storage
- Packaging: Sealed and light-proof packaging is adopted. Conventional specifications include 1g, 5g, 25g, 100g, 500g, 1kg, etc., and can be customized according to scientific research or industrial needs.
- Storage: Sealed, dry, cool and ventilated place, away from direct sunlight, high temperature and humid environment.
- Transportation: Transport as general chemical products, away from strong oxidants, strong acids and alkalis, prevent leakage and moisture.
- Validity Period: Shelf life is not less than 2 years under specified storage conditions.
—— C ompany Profile ——
Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.
Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.
We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.
To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.
Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.
—— Q&A ——
Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.
Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.
Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.
Q4: What is your MOQ? Is there a discount?
A: For high value products, our MOQ starts from 1g and generally starts from 10g. For other low price products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.
Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.
