—— Product Specifications ——
| Parameter | Specification | Details |
| Product Name | Eribulin mesylate intermediate | Methyl 2-((2R,4aS,6S,7R,8S,8aS)-7,8-bis((tert-butyldimethylsilyl)oxy)-6-((S,E)-1-((tert-butyldimethylsilyl)oxy)-3-iodoallyl)octahydropyrano[3,2-b]pyran-2-yl)acetate |
| CAS Number | 157322-83-3 | 157322-83-3 |
| Molecular Formula | C₃₂H₆₃IO₇Si₃ | 32 carbons, 63 hydrogens, 1 iodine, 7 oxygens, 3 silicons |
| Molecular Weight | 771.01 g/mol | — |
| Appearance | White to off-white solid | Visual inspection |
| Purity | ≥95.0% | Determined by HPLC |
| Storage | Cool, dry place, store long-term | Sealed containers, protect from moisture |
| Packaging | 10mg, 50mg, 100mg, bulk | Amber glass vials |
| Application | Research use only | Pharmaceutical intermediate for API synthesis |
—— Product Detail ——
Product Overview
Eribulin mesylate intermediate (CAS 157322-83-3) is a highly advanced, fully protected intermediate in the industrial synthesis of eribulin mesylate (Halaven®), a synthetic microtubule inhibitor approved for the treatment of metastatic breast cancer. This compound embodies the entire C14–C35 architectural domain of eribulin, featuring three tert-butyldimethylsilyl (TBS) protecting groups and a stereodefined E-vinyl iodide moiety. With the molecular formula C₃₂H₆₃IO₇Si₃ and a molecular weight of 771.01 g/mol, it represents one of the most synthetically complex and high-value intermediates in the eribulin supply chain
Synthetic Process
This intermediate is synthesized through an iterative fragment coupling strategy, serving as a key building block in the convergent Nozaki–Hiyama–Kishi (NHK) fragment coupling approach. The compound features three TBS protecting groups that safeguard reactive hydroxyl functionalities throughout the multi-step synthesis, and a stereodefined E-vinyl iodide moiety essential for the final macrocyclization to the active pharmaceutical ingredient (API).
Mechanism of Action
As a synthetic intermediate, this compound is not pharmacologically active itself. It serves as a crucial building block that enables the construction of eribulin mesylate, a potent microtubule dynamics inhibitor. Eribulin binds to the growing ends of microtubules, suppressing microtubule growth and leading to G2/M cell cycle arrest and apoptosis in cancer cells.
Quality Specifications
-
-
Purity: ≥95.0% determined by HPLC
-
Identity confirmed by NMR and mass spectrometry
-
Each batch accompanied by comprehensive Certificate of Analysis (COA)
-
Store in a cool, dry place protected from moisture
Packaging & Shipping
-
-
Research quantities: 10mg, 50mg, 100mg amber glass vials
-
Bulk quantities available upon request
-
Custom packaging available upon request
-
Not classified as hazardous material for transport
-
-
— Company profiles ——
Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.
Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.
We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.
To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.
Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.
—— Q&A ——
Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.
Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.
Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.
Q4: What is your MOQ? Is there a discount?
A: For high value products, our MOQ starts from 1g and generally starts from 10g. For other low price products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.
Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.
