Infigratinib CAS NO 872511-34-7 99% high purity DIDEU white crystalline powder

Infiglatinib (BGJ398) is an ATP competitive pan FGFR inhibitor developed jointly by BridgeBio Biopharmaceuticals and Liantuo Biotech. It was approved by the FDA on May 28, 2021, for the treatment of advanced or metastatic cholangiocarcinoma patients with FGFR2 mutations in Chemicalbook therapy. Adding this drug, the FDA has approved three drugs, the other two being Pemigatinib [FDA/NMPA] and Futibatinib [FDA].

The mechanism of action of Infiglatinib is through highly selective inhibition of the activity of FGFR1, FGFR2, FGFR3, and FGFR4, acting at the biochemical and cellular levels in Chemicalbook. The activation of the FGFR pathway is associated with the proliferation of malignant cancer cells, therefore, inhibition of FGFR specific kinases can effectively reduce the proliferation of tumor cells

BGJ398 is an effective and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinases. Bioactive BGJ398 (NVP-BGJ398) is an effective and selective FGFR inhibitor that acts on FGFR1/Chemicalbook2/3 with an IC50 of 0.9nM/1.4nM/1nM. Its selectivity towards FGFR is over 40 times higher than that towards FGFR4 and VEGFR2, and it has almost no inhibitory activity against Abl, Fyn, Kit, Lck, Lyn, and Yes.

English synonyms
3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea;BGJ398;BGJ398(NVP-BGJ398);NVP-BGJ3983-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea;Urea,N'-(2,6-dChemicalbookichloro-3,5-dimethoxyphenyl)-N-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-N-methyl-,methanesulfonate;Urea,N'-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-N-methyl-;NVP-BGJ398,>=98%;NVP-BGJ398(Infigratinib)

Advantage
1)Widely used for rinsing stains
2)Active at 20 ° C
3)Has antibacterial properties
4)Strong deodorization effect
5)Small amount of addition
6)Not causing allergies
7)Easy to use
8)For human safety
9)Safe for fibers and colors
10)No VOC release
11)Chlorine free
12)No Seveso

matters needing attention

Safe storage: 4-Butylresorcinol should be stored in a dry, well ventilated environment, away from heat sources, fire sources, and open flames.

Personal protection: Appropriate personal protective equipment such as gloves, goggles, and protective clothing should be worn during operation.

Environmental impact: When handling 4-n-butylresorcinol, it should be avoided from entering the environment to prevent adverse effects on the environment and health.

Our Services

a) Free sample can be supplied.
b) Guide our clients by professional knowledge and teach them how to use our product after sales.
c) Accept SGS, BV any other third-party inspection before loading.
d) High quality best price Guaranteed.

Why do you choose Dideu Industries as your partner?
A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.
B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.
C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.
D) Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.

Packaging and Shipping

Our normal packaging is 25kgs/Drum and 200kgs/Drum.
The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

Our company has various payment methods.

For example: bank transfer, LC at sight,and so on.