Putrescine Dihydrochloride (1,4-Diaminobutane Dihydrochloride) CAS 300-57-2 98% White Crystalline Powder | Aliphatic Diamine Dihydrochloride / Build

1. Product Overview

Putrescine dihydrochloride (CAS 300-57-2), systematically named butane-1,4-diamine dihydrochloride (C₄H₁₂N₂·2HCl, MW 161.07 g/mol), is the stable hydrochloride salt of the aliphatic diamine putrescine. The two primary amine groups are protonated and balanced by chloride ions, rendering the solid non-hygroscopic and easy to handle. Upon dissolution in water or mild base, the free diamine is released in situ and can participate in acylation, Schiff base formation, or condensation reactions. Used as a C₄ diamine spacer in polymer and small-molecule synthesis research.

2. Key Features and Benefits

• Stable Dihydrochloride Salt: Non-hygroscopic crystalline solid; easier to weigh and store than the free diamine (which is volatile and oxidized).

• Two Primary Amines: Enable stepwise or symmetrical bis-acylation, imine formation, and Michael addition after basification.

• C₄ Spacer: Introduces a flexible four-carbon chain with terminal NH₂ groups in molecular architecture studies.

• High Purity: Supplied ≥98% (Titration/HPLC), suitable for polycondensation and crosslinker synthesis.

3. Major Applications

• Organic / Polymer Synthesis: Used in polycondensation with diacids/diacyl chlorides to form polyamides or polyurethanes incorporating a C₄ diamine unit.

• Crosslinker / Spacer Research: Bis-functionalized to generate glutaraldehyde-crosslinked networks or fluorescent probe tethers after deprotonation.

• Heterocycle Formation: Condensation with 1,3-dicarbonyls or diesters under high-T to afford seven-membered diazacycloheptane derivatives (methodology studies).

• Protecting Group / Derivatization: Amines protected as phthalimides (Gabriel) or Boc derivatives for orthogonal deprotection sequences.

• Analytical Reference: Standard for ion chromatography or HPLC method development quantifying aliphatic diamines.

4. Technical Specifications

Item Description
Product Name Putrescine Dihydrochloride (1,4-Diaminobutane Dihydrochloride)
Synonyms Butane-1,4-diamine dihydrochloride; 1,4-Butanediamine dihydrochloride
CAS Number 300-57-2
Molecular Formula C₄H₁₂N₂·2HCl
Molecular Weight 161.07 g/mol
MDL Number MFCD00012862
PubChem CID 10142913
Assay (Purity) ≥98% (Titration / HPLC)
Appearance White to off-white crystalline powder
Melting Point 295–300 °C (decomposes, Literature)
Solubility Freely soluble in water (>100 mg/mL); slightly soluble in methanol; insoluble in ether, chloroform, hydrocarbons.
pH (1% aq.) ~4.5–5.5
Calculated LogP (free base) ~0.05
Polar Surface Area (free base) 52.0 Ų
Hydrogen Bond Donors (free base) 2 (NH₂ ×2)
Hydrogen Bond Acceptors (free base) 2 (N ×2)
SMILES NCCCCN.Cl.Cl
InChI Key KIDHWZIDEKGBKF-UHFFFAOYSA-N — verify via database
Storage RT or 2–8 °C, sealed, protect from moisture; stable ≥24 months
HS Code 2921.29.90 / 3822.90.00

5. Storage and Handling

Store in a tightly sealed container at room temperature or 2–8 °C, protected from moisture. The dihydrochloride salt is stable and minimally hygroscopic. Dissolve in water or methanol; for free diamine generation add equimolar K₂CO₃ or NaOH and extract with an organic solvent if needed. Handle with standard PPE. Avoid mixing with strong oxidizers.

6. Safety Summary

• GHS Classification: GHS07 – Warning

• Signal Word: Warning

• Hazard Statements: H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation)

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