Calcium Pantothenate (Vitamin B5 Calcium Salt)

CAS Registry Number: 137-08-6

Overview

Calcium pantothenate is the calcium salt of D-pantothenic acid (Vitamin B5). It is a stable, solid form of the vitamin commonly used in supplements and fortified foods . Its chemical formula is C₁₈H₃₂CaN₂O₁₀, with a molecular weight of 476.54 g/mol .

Key Properties

• Appearance: White to off-white crystalline powder 

• Melting Point: Approximately 190°C (decomposes) 

• Solubility: Soluble in water 

• Specific Rotation: +25.5° to +27.5° 

• Storage: Stable at room temperature short-term; long-term storage recommended at 2–8°C in airtight, light-protected containers 

Physiological Role

Calcium pantothenate serves as a precursor in the biosynthesis of coenzyme A (CoA), an essential cofactor involved in the citric acid cycle and fatty acid metabolism . It plays a critical role in the metabolism of proteins, carbohydrates, and fats .

Applications

Dietary Supplement

Widely used as a source of Vitamin B5 in multivitamins, dietary supplements, and fortified foods .

Food Additive

Affirmed as GRAS (Generally Recognized as Safe) by the U.S. FDA for use as a nutrient supplement in foods, including infant formula, with no limitation other than current good manufacturing practice .

Pharmaceutical and Research

• Used in pharmaceutical preparations 

• Employed in research for studies involving coenzyme A synthesis and cellular metabolism 

Safety and Handling

• Hazards: May cause transient irritation to eyes, skin, and respiratory tract 

• Stability: Hygroscopic; sensitive to air, light, and moisture 

• Incompatibilities: Incompatible with strong oxidizing agents