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Calcium pantothenate

Calcium pantothenate structure

CAS No:
137-08-6
Formula:
C9H17NO5.¹/2Ca
Chemical Name:
Calcium pantothenate
Synonyms:
β-Alanine,N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]-,calcium salt (2:1);Pantothenic acid,calcium salt (2:1),D-;β-Alanine,N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-,calcium salt (2:1),(R)-;Calcium,bis(pantothenato)-;Calcium D-(+)-N-(α,γ-dihydroxy-β,β-dimethylbutyryl)-β-alaninate;Calpanate;Dextro calcium pantothenate;N-(2,4-Dihydroxy-3,3-dimethylbutyryl)-β-alanine calcium;Pancal;Panthoject;Pantholin;Pantothenate calcium;(+)-Pantothenic acid calcium salt;Calcium pantothenate;Pantothenic acid calcium salt;Vitamin B5 calcium salt;Calcium D-pantothenate;Calcium D-(+)-pantothenate;Pantothenic acid hemicalcium salt;Calpan;NSC 36292;Panthothenic acid hemicalcium salt;D-Pantothenic acid hemicalcium salt;138932-10-2;533-61-9;7693-16-5
Categories:
Cosmetic Ingredient > Hair Conditioning

Description

D-Pantothenic acid hemicalcium salt, a kind of water solublevitamin, can reduce the patulin content of the apple juice.IC50 value:Target:In vitro: In human dermal fibroblasts from three different donors, D-Pantothenic acid hemicalcium salt accelerates the wound healing process by increasing the number of migrating cells, their distance and hence their speed. In addition, cell division is increased and the protein synthesis changed [1].In vivo:

Calcium pantothenate Basic Attributes

Molecular Weight：

476.53200

Exact Mass：

476.16800

EC Number：

205-278-9

DSSTox ID：

DTXSID8040438

HScode：

2936240000

Characteristics

PSA：

191.72000

XLogP3：

-1.45900

Appearance：

White or almost white Powder

Density：

1.266g/cm3

Melting Point：

195-196 °C (decomp)

Boiling Point：

551.5ºC at 760 mmHg

Flash Point：

287.3ºC

Refractive Index：

27 ° (C=5, H2O)

Storage Conditions：

2-8ºC

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R20/21/22

safety instructions：

S24/25

RTECS Number：

RU4375000

Marks：

Stability/Shelf Life：

Stable, but may be moisture or air sensitive. Incompatible with strong acids, strong bases.

Calcium pantothenate Use and Manufacturing

Methods of Manufacturing

The solid of Example 5 was added to a 10-L jacketed mechanically stirred glass reactor, 5 L of ethanol was added, and the mixture was thoroughly stirred by mechanical stirring (200 rpm).69.2 g of metal calcium (molar ratio of β-aminopropionic acid and metal calcium was 2:1.02) was added thereto, and the temperature of the reaction vessel was controlled to 75 ° C by a constant temperature water bath, and the reaction was refluxed for 6 hours, and the reaction liquid was filtered.444.5 g of D-pantolactone was added to the filtrate, and the mixture was thoroughly stirred by mechanical stirring (200 rpm), and the temperature of the reaction vessel was controlled to 75 ° C by a constant temperature water bath, and the reaction was refluxed for 16 hours.During the period, the consumption of D-lactone was monitored by HPLC to follow the progress of the reaction. After the reaction was completed, the reaction solution was filtered, and the filtrate was concentrated and dried to obtain 0.776 kg of calcium D-pantothenate, and the yield was 96percent.The measured calcium content was 8.6percent and the specific rotation was +26.2.3-Aminopropionic acid (4.45 g, 0.05 mol), calcium oxide (1.68 g, 0.03 mol) were added to a 100 mL ball mill, Sodium chloride (12.26 g), Then add two iron balls with a diameter of 30 mm.Perform a mechanical ball mill for 30 min (frequency 30 Hz) The reaction mixture is reacted. to(6.50 g, 0.05 mol), sodium chloride (13 g), ball mill Rate 30 Hz, after 30 min, add the previous step after the ball mill solid powder. Ball mill frequency 30 Hz, time 30 min, take The reaction mixture was removed and the product was dissolved in methanol (85 mL), filtered and concentrated to crystallize. The product was filtered and dried to give a white powder Vitamin B5 (8.45 g, yield 71percent).

Uses

A member of the B complex vitamins; essential vitamin for the biosynthesis of coenzyme A in mammalian cells. Occurs ubiquitously in all animal and plant tissue. The richest common source is liver, but jelly of the queen bee contains 6 times as much as liver. Rice bran and molasses are other good sources.

Manufacturing Info：

.beta.-Alanine, N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]-, calcium salt (2:1): ACTIVE

Use Classification：

EPA Safer Chemical Functional Use Classes -> Skin Conditioning Agents|Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern|Cosmetics -> Antistatic; Hair conditioning

Computed Properties

Molecular Weight:494.5
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:14
Exact Mass:494.1788508
Monoisotopic Mass:494.1788508
Topological Polar Surface Area:220
Heavy Atom Count:32
Complexity:534
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:4
Compound Is Canonicalized:Yes

Material

Potassium carbonate

Sulfuric acid

Isobutyraldehyde

Price Analysis

Make your Calcium pantothenate purchase based on the price and market insights! ECHEMI provides professional market insights with prices for you to make a better choice. Learn more on Calcium pantothenate prices .

Drug Function and Efficacy

It constitutes a variety of coenzymes, participates in the metabolism, utilization and synthesis of a variety of substances, promotes bone growth, maintains the structural integrity of epithelial tissue, and maintains normal growth and development

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Multivitamin tablets
Ingredients	12 vitamins: Vitamin A (4000 IU) 1.2 mg; Vitamin B1 1.6 mg; Vitamin B2 1.8 mg; Vitamin B6 2.6 mg; Vitamin B12 4.0 mg; Vitamin C 0.1 g; Vitamin D3 (500 IU) 12.5 micrograms; Vitamin E 15 mg; Biotin 0.2 mg; Folic acid 0.8 mg; Nicotinamide 19 mg; Calcium pantothenate 10 mg. 7 minerals and trace elements: Calcium 0.125 g; Magnesium 0.1 g; Phosphorus 0.125 g; Copper 1 mg; Iron 60 mg; Manganese 1 mg; Zinc 7.5 mg;
Indication	1. It should not be used with tetracycline drugs. If necessary, the two drugs should be taken at least two hours apart. 2. It should not be used with other drugs containing vitamin A and vitamin D. 3. This product should not be used with carbamazepine, phenytoin, primidone and barbiturates. 4. If used with other drugs at the same time, drug interactions may occur. Please consult your doctor or pharmacist for details.
Specifications	60s

Vitamin B complex tablets
Ingredients	This product is a compound preparation. Each tablet contains the following main ingredients: Vitamin B13 mg, Vitamin B21.5 mg, Vitamin B60.2 mg, Nicotinamide 10 mg, Calcium Pantothenate 1 mg
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Compound

Five vitamin oral solution
Ingredients	This product contains 0.3 mg of vitamin B1, 0.06 mg of vitamin B2, 0.09 mg of vitamin B6, 0.3 mg of niacinamide, and 0.03 mg of calcium pantothenate per milliliter. The auxiliary materials are orange peel tincture, citric acid, ethanol, sucrose, and sodium benzoate.
Indication	If you are taking other medicines, please consult your doctor or pharmacist before using this product.
Specifications	Compound

See More Related Drugs

Registered Holders

BASF SE

Denmark
Active
XINFA Pharmaceutical Co., Ltd.

China
Active
DSM Vitamins Trading (SHANGHAI) Co., Ltd.

China
Active

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