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Methyl vanillate3943-74-6

Name: Methyl vanillate3943-74-6
Brand: OORENT
SKU: pr2607093322
Price: 22 USD
Availability: InStock

3 Inquiries

Unit Price:

$22-23/MT FOB

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CAS No.:

3943-74-6

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

OORENT

Packaging:

vial

Price valid (until):

2026-08-09

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Detail

Methyl vanillate Basic information

Product Name:	Methyl vanillate
Synonyms:	Methyl vanillate 99%;4-Hydroxy-3-methoxybenzoic Acid Methyl Ester Methyl 4-Hydroxy-3-methoxybenzoate Vanillic Acid Methyl Ester;4-HYDROXY-3-METHOXYBENZOIC ACID METHYL ESTER;Methylevanillate;METHYL 4-HYDROXY-3-METHOXYBENZOATE;METHYL VANILLATE;METHYL 3-METHOXY-4-HYDROXYBENZOATE;RARECHEM AL BF 0101
CAS:	3943-74-6
MF:	C9H10O4
MW:	182.17
EINECS:	223-525-9
Product Categories:	FINE Chemical & INTERMEDIATES;Aromatic Esters;Building Blocks;C8 to C9;Carbonyl Compounds;Chemical Synthesis;Esters;Organic Building Blocks;Inhibitors
Mol File:	3943-74-6.mol

Methyl vanillate Chemical Properties

Melting point	64-67 °C (lit.)
Boiling point	285-287 °C (lit.)
density	1.2481 (rough estimate)
refractive index	1.4500 (estimate)
Fp	285-287°C
storage temp.	Sealed in dry,Room Temperature
solubility	Soluble in chloroform and methanol.
pka	8.36±0.18(Predicted)
form	Powder and Granules
color	Pale yellow to beige
Odor	at 100.00 %. warm spicy vanilla guaiacol phenolic carnation
Odor Type	vanilla
biological source	synthetic
BRN	1369113
Cosmetics Ingredients Functions	PERFUMING
InChI	1S/C9H10O4/c1-12-8-5-6(9(11)13-2)3-4-7(8)10/h3-5,10H,1-2H3
InChIKey	BVWTXUYLKBHMOX-UHFFFAOYSA-N
SMILES	COC(=O)c1ccc(O)c(OC)c1
LogP	2.231 (est)
CAS DataBase Reference	3943-74-6(CAS DataBase Reference)
NIST Chemistry Reference	Benzoic acid, 4-hydroxy-3-methoxy-, methyl ester(3943-74-6)
EPA Substance Registry System	Benzoic acid, 4-hydroxy-3-methoxy-, methyl ester (3943-74-6)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-24/25
WGK Germany	3
RTECS	DH2430000
TSCA	TSCA listed
HS Code	29189900
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

MSDS Information

Provider	Language
Methyl 4-hydroxy-3-methoxybenzoate	English
ACROS	English
SigmaAldrich	English
ALFA	English

Methyl vanillate Usage And Synthesis

Chemical Properties	pale yellow to beige powder and granules
Uses	Methyl Vanillate maintains antimicrobial properties due to the phenylpropanoid moiety in the structure.
Uses	Methyl vanillate is used to investigate the volatile compounds of heather honeys from Calluna vulgaris and Erica arborea.
Definition	ChEBI: Methyl vanillate is a benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite. It is a benzoate ester, a member of phenols and an aromatic ether. It is functionally related to a vanillic acid.
General Description	Methyl vanillate is a volatile compound present in cloudberries (Rubus Chamaemorus.). Methyl vanillate can be synthesized from vanillic acid. Methyl vanillate has been identified in foods such as cow's milk and beer.
Biological Activity	Methyl vanillate, one of the ingredients in Hovenia dulcis Thunb, is a Wnt/β-catenin pathway activator. A benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite.
References	[1] PU-HYEON CHA. Hovenia dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice.[J]. PLoS ONE, 2014: e85546. DOI:10.1371/journal.pone.0085546. [2] ADRIANO DE SOUZA PESSOA . The dimerization of methyl vanillate improves its effect against breast cancer cells via pro-oxidant effect[J]. Chemico-Biological Interactions, 2022, 361: Article 109962. DOI:10.1016/j.cbi.2022.109962. [3] CHRONG-SHYUA CHU P. D R C Liao. A formal synthesis of (+/-)-reserpine from methyl vanillate[J]. Chemical Communications, 1996, 1 1: 1537-1538. DOI:10.1039/CC9960001537. [4] JUAN TIAN. Ethyl acetate as a co-solvent and sacrificial ester in the aluminum triiodide promoted chemoselective demethylation of methyl vanillate[J]. Tetrahedron Letters, 2017, 58 36: Pages 3522-3524. DOI:10.1016/j.tetlet.2017.07.089.

Methyl vanillate Preparation Products And Raw materials

Raw materials	Syringaldehyde-->Methyl syringate-->Methanol-->Vanillin
Preparation Products	Methyl 3,4-dihydroxybenzoate-->Methyl 4-(benzyloxy)-5-methoxy-2-nitrobenzoate-->AGMWEOLWLPKJFM-UHFFFAOYSA-N-->UNC-0642-->Methyl 4-chloro-3-methoxy-5-nitrobenzenecarboxylate-->4-BENZYLOXY-5-METHOXY-2-NITRO-BENZOIC ACID-->4-Chloro-6-methoxy-7-(3-piperidin-1-yl-propoxy)-quinazoline-->Protocatechuic acid-->Benzoic acid, 3-methoxy-4-propoxy-, methyl ester

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Basic Info

Product Name:

Methyl vanillate

Other Name:

Benzoic acid,4-hydroxy-3-methoxy-,methyl ester;Vanillic acid,methyl ester;Methyl 3-methoxy-4-hydroxybenzoate;Methyl vanillate;Methyl 4-hydroxy-3-methoxybenzoate;4-Hydroxy-3-methoxybenzoic acid methyl ester;NSC 74385;1220026-96-9

CAS No.:

3943-74-6

Molecular Formula:

C9H10O4

InChIKeys:

InChIKey=BVWTXUYLKBHMOX-UHFFFAOYSA-N

Molecular Weight:

182.175

Exact Mass:

182.17

EC Number:

223-525-9

UNII:

2HXG8QSO3D

NSC Number:

74385

DSSTox ID:

DTXSID5074345

HScode:

2918990090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

55.8

XLogP3:

1.8

Appearance:

pale yellow to beige powder and granules

Density:

1.2±0.1 g/cm3

Melting Point:

64 °C

Boiling Point:

286 °C

Flash Point:

120.2±15.8 °C

Refractive Index:

1.534

Storage Conditions:

Store in a cool, dry place. Keep container closed when not in use.

See More Methyl vanillate Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Methyl vanillate Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

3 Inquiries

Country	Product	Purchase Quantity	Date Posted
United Kingdom	Methyl vanilate	10 G	Jul 9, 2026
United States	Methyl Vanillate	10 MT	Jan 2, 2025
United States	Methyl Vanillate	5 G	Jul 7, 2026

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