 Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > 5-N,6-N-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine for Sale > N,N'-bis(2-fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine CAS:210302-17-3

N,N'-bis(2-fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine CAS:210302-17-3 buy - large image1

N,N'-bis(2-fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine CAS:210302-17-3 buy - image1

N,N'-bis(2-fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine CAS:210302-17-3 buy - image2

N,N'-bis(2-fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine CAS:210302-17-3 buy - image3

N,N'-bis(2-fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine CAS:210302-17-3 buy - image4

N,N'-bis(2-fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine CAS:210302-17-3

Name: N,N'-bis(2-fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine CAS:210302-17-3
Brand: Orient
SKU: pr2512221095
Price: 4 USD
Availability: InStock

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CAS No.:

210302-17-3

Grade:

Industrail Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

25L, 200L, 1000L, customized

Price valid (until):

2026-01-22

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Name:	BAM15
Synonyms:	;N,N'-bis(2-fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine;CS-2890;[1,2,5]Oxadiazolo[3,4-b]pyrazine-5,6-diamine, N5,N6-bis(2-fluorophenyl)-;BAM15 >=98% (HPLC);BAM 15 (N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine);inhibit,BAM-15,Inhibitor,BAM 15,BAM15,Mitochondrial Metabolism;, 10 mM in DMSO
CAS:	210302-17-3
MF:	C16H10F2N6O
MW:	340.29
EINECS:	201-118-7
Product Categories:	API
Mol File:	210302-17-3.mol

BAM15 Chemical Properties

Boiling point	421.7±55.0 °C(Predicted)
density	1.548±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (35 mg/ml)
form	powder
pka	-2.40±0.50(Predicted)
color	white to beige
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChI	InChI=1S/C16H10F2N6O/c17-9-5-1-3-7-11(9)19-13-14(20-12-8-4-2-6-10(12)18)22-16-15(21-13)23-25-24-16/h1-8H,(H,19,21,23)(H,20,22,24)
InChIKey	OEGJBRZAJRPPHL-UHFFFAOYSA-N
SMILES	C12=NON=C1N=C(NC1=CC=CC=C1F)C(NC1=CC=CC=C1F)=N2

Safety Information

MSDS Information

BAM15 Usage And Synthesis

Description	B (210302-17-3) is a mitochondrial protonophore uncoupler with fewer off-target effects (EC50 = 270 nM in L6 myoblast mitochondria.)1,2 Compared to FCCP, an uncoupler of equal potency, stimulates a higher maximum rate of mitochondrial respiration and does not depolarize the plasma membrane.2 Stimulates energy expenditure, protects against obesity and improves glycemic control in rodent models.3 Reverses diet-induced obesity and insulin resistance in mice.4 Attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue.5
Uses	BAM 15, is a mitochondrial protonophore uncoupler that does not depolarize the plasma membrane and protects mice from acute renal ischemic-reperfusion injury.
Biochem/physiol Actions	increases mitochondrial respiration rate and is also found to be less cytotoxic compared to other protonophore uncouplers such as carbonyl cyanide p-trifluoromethoxyphenylhydrazone. Hindered oncogenic MAPK (mitogen-activated protein kinase ) signaling leads to BAM15 induced mitochondrial apoptotic pathway activation.
Enzyme inhibitor	This novel mitochondrial uncoupler (FW = 340.29 g/mol), also named (2- fluorophenyl)-{6-[(2-fluorophenyl)amino]-(1,2,5-oxadiazolo[3,4-e]pyrazin- 5-yl)}amine, exhibits a broad effective range of H+ gradient-dissipating action without affecting plasma membrane electrophysiology. With FCCP as an equipotent positive control, BAM15 was found to be fully able to increase mitochondrial respiration in the presence of oligomycin over a broader concentration range than FCCP in both myoblasts and hepatocytes. BAM15 and FCCP had similar effects on mitochondrial depolarization in L6 myoblasts treated with concentrations of each uncoupler at 1 and 10 μM, as measured by tetramethylrhodamine (TMRM) fluorescence. Neither FCCP nor donates electrons to the Electron Transport Chain. Although some non-protonophoric uncouplers increase proton transport into the matrix via interaction with the mitochondrial inner membrane adenine nucleotide translocase (ANT), neither nor FCCP requires the ANT to increase mitochondrial respiration.
storage	Store at -20°C
References	[1] BRANDON M. KENWOOD . Structure–activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers[J]. Bioorganic & Medicinal Chemistry Letters, 2015, 25 21: Pages 4858-4861. DOI:10.1016/j.bmcl.2015.06.040 [2] BRANDON M. KENWOOD . Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane[J]. Molecular Metabolism, 2014, 3 2: Pages 114-123. DOI:10.1016/j.molmet.2013.11.005 [3] CHRISTOPHER L AXELROD. BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control.[J]. EMBO Molecular Medicine, 2020, 12 7: e12088. DOI:10.15252/emmm.202012088 [4] STEPHANIE J ALEXOPOULOS. Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice.[J]. ACS Combinatorial Science, 2020: 2397. DOI:10.1038/s41467-020-16298-2 [5] MINGJUN TANG. BAM15 attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue.[J]. Stem Cell Research & Therapy, 2019: 64. DOI:10.1186/s13287-019-1151-y

First aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak. Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

5-N,6-N-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine

Other Name:

BAM 15;210302-17-3;BAM15;N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine;5-N,6-N-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine;n5,n6-bis(2-fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine;(2-fluorophenyl){6-[(2-fluorophenyl)amino](1,2,5-oxadiazolo[3,4-e]pyrazin-5-yl )}amine;N-[6-(2-Fluoroanilino)[1,2,5]oxadiazolo[3,4-b]pyrazin-5-yl]-N-(2-fluorophenyl)amine;Oprea1_627044;CHEMBL3627755

CAS No.:

210302-17-3

Molecular Formula:

C16H10F2N6O

InChIKeys:

OEGJBRZAJRPPHL-UHFFFAOYSA-N

Molecular Weight:

340.29

Exact Mass:

340.08841529

Categories:

Bulk Drug Intermediates

Characteristics

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

10 Inquiries

Country	Product	Purchase Quantity	Date Posted
United Kingdom	Bam-15 Raw Powder BAM 15 CAS 210302-17-3	1 KG	Dec 20, 2025
Australia	BAM-15 Weight Loss Supplement 98% Powder 210302-17-3 Senwayer	50 G	Oct 31, 2023
United States	BAM-15 Weight Loss Supplement 98% Powder 210302-17-3 Senwayer	1 KG	Sep 23, 2023
United States	BAM-15	1	Mar 10, 2024
Netherlands	BAM 15	20 G	Mar 30, 2026
Austria	BAM-15 powder	50 G	Mar 16, 2026
United States	BAM-15	10 G	Mar 18, 2026
Latvia	BAM 15	100 G	Jul 21, 2025
United Kingdom	Bam-15 Raw Powder BAM 15 CAS 210302-17-3	100 G	Oct 14, 2025
Portugal	Ru-58841	100 G	Apr 23, 2026

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N,N'-bis(2-fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine CAS:210302-17-3

Product Description

Seller Information

Inquiry History

First aid measures

Accidental release measures

Personal precautions, protective equipment and emergency procedures

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