IGD

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I. IGD Tripeptide (Ile-Gly-Asp, fibronectin active motif)
Mechanism of action
It is naturally present in fibronectin and differs from RGD peptide. It specifically activates fibroblast migration signals and only acts in the collagen matrix environment, without the broad binding characteristic of integrins.
Strongly promotes fibroblast migration (core function)
In vitro skin cell experiments can quickly activate the mobility of dermal fibroblasts and accelerate the aggregation of cells towards the damaged area; activity intensity ranking: IGD S > IGD Q > IGD basic tripeptide, which is the core raw material for chronic wound repair research (PubMed).
Optimize collagen matrix adhesion and remodeling
Enhance the adhesion ability of cells to natural type I collagen, stimulate cells to secrete collagen and fibronectin, and build a complete extracellular matrix; only effective on native collagen, and has no significant effect on denatured collagen.
Accelerate the healing of epidermal wounds in vitro model effect
In scratch experiments, shorten the cell closing cycle. Conduct mechanism research on difficult-to-heal wounds (metabolic damage type wounds), improve the problem of slow cell crawling.
Mild anti-inflammatory, reduce wound oxidative stress
Down-regulate local reactive oxygen species and inflammatory factors in the wound, reduce cell apoptosis in the damaged area, and maintain the activity of repairing cells.
Basic research for soft tissue repair application
Used for in vitro screening of skin abrasions, mucosal damage, and connective tissue injuries; does not stimulate abnormal cells to over-proliferate, and has better safety than most growth-promoting peptides. Limitation
Only effective at the cellular level, no compliant externally-applied finished product; cannot penetrate intact healthy epidermis, only acts on the surface cells of damaged skin.
II. IGD (Trade Item Number, IGF-1 DES 1-3, truncated IGF peptide)
Basic principle
Remove the 3 amino acids at the front end of IGF-1 and modify the peptide, not binding to IGF binding proteins (IGFBPs), freely activating the IGF-1 receptor, with stronger pathway activity and faster onset, only as laboratory research reagents.
Muscle cell anabolic metabolism, repairing muscle fibers
Activate the mTOR pathway to enhance muscle protein synthesis, inhibit muscle breakdown; stimulate the proliferation of muscle satellite stem cells, repair damaged muscle cells, used in in vitro experiments for muscle atrophy, aging sarcopenia.
Enhance the anti-apoptotic ability of systemic cells
Stabilize mitochondrial membrane potential, block programmed cell death induced by oxidation, hypoxia, and toxins; protective effects exist in cardiac, neural, liver, kidney, and cartilage cells.
Bone and cartilage cell maintenance
Promote the proliferation of osteoblasts and bone matrix mineralization, inhibit osteoclast bone resorption; enhance the secretion of type II collagen and glycosaminoglycan, reduce the loss of cartilage cells caused by inflammation.
Sugar metabolism, improving insulin cell sensitivity
Promote the expression of glucose transport proteins in the cell membrane, accelerate sugar intake and utilization; improve insulin resistance induced by high sugar and high fat in cells, balance lipid metabolism, reduce triglyceride accumulation in cells.
Skin dermal anti-aging in vitro effect
Stimulate fibroblasts to secrete type I/III collagen, resist damage from ultraviolet free radicals; accelerate the renewal of keratinocytes, reduce collagen degradation and cell damage related to wrinkles caused by photoaging.
Multi-organ antioxidant protection
Protect vascular endothelium, liver cells, renal tubular cells, alleviate oxidative inflammatory damage, inhibit the activation of organ fibrosis signals.

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GHS label elements, including precautionary statements

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Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.