—— Product Specifications ——

—— Product Detail ——

• • • • • • • • • • • • • • • • Product Overview

                                1-Aminocyclohexanecarboxylic acid is a cyclic, non-proteinogenic amino acid with the molecular formula C₇H₁₃NO₂ and a molecular weight of 143.19 g/mol. This white to off-white crystalline powder features an amino group and a carboxylic acid group attached to the same carbon atom of a cyclohexane ring, creating a sterically hindered, conformationally constrained amino acid structure. This unique structure imparts significant rigidity to peptides and other molecules incorporating this building block, making it valuable for structure-activity relationship studies and the development of peptidomimetics. The compound is also known as 1-amino-1-carboxycyclohexane or cyclohexane-1-amino-1-carboxylic acid.

                                Synthetic Process

                                1-Aminocyclohexanecarboxylic acid is synthesized through the following routes:

                                • Bucherer-Bergs reaction: Cyclohexanone is reacted with ammonium carbonate and potassium cyanide to form the corresponding hydantoin, which is subsequently hydrolyzed under basic conditions to yield the amino acid.

                                • Strecker synthesis: Cyclohexanone is converted to the aminonitrile via reaction with ammonium chloride and sodium cyanide, followed by acid hydrolysis to yield the amino acid.

                                • Purification: The crude product is purified by recrystallization from water or water-ethanol mixtures.

                                Mechanism of Action / Application Principles

                                • Conformationally Constrained Amino Acid: The cyclohexane ring restricts the conformational flexibility of the amino acid backbone, allowing for the stabilization of specific peptide conformations (such as beta-turns and helices) in peptidomimetic design.

                                • Peptide Synthesis: Serves as a building block for introducing constrained residues into peptide sequences, enhancing stability and bioactivity.

                                • Drug Discovery: Used in the development of enzyme inhibitors and receptor ligands where conformational restriction improves binding affinity and selectivity.

                                • Structure-Activity Relationship Studies: Valuable tool for probing the conformational requirements of bioactive peptides and proteins.

— C ompany Profile ——

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

—— Q&A ——

Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

Q4: What is your MOQ? Is there a discount?
A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.

Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.