—— Product Specifications ——

—— Product Detail ——

• • • • • • • • • • • • • • • • • Product Overview

                                  1-Aminocyclopropanecarboxylic acid (ACC) is a naturally occurring, non-proteinogenic amino acid with the molecular formula C₄H₇NO₂ and a molecular weight of 101.10 g/mol. This white to off-white crystalline powder is the immediate biosynthetic precursor of ethylene in plants, making it one of the most important small molecules in plant physiology research.

                                  The compound features a highly strained cyclopropane ring fused to an amino acid moiety, creating a rigid, conformationally constrained structure that restricts backbone flexibility. Beyond its biological significance in the ethylene biosynthesis pathway, ACC serves as a valuable building block in organic synthesis for the introduction of cyclopropane-containing amino acid residues into peptides and peptidomimetics, imparting conformational rigidity and enhancing biological stability.

                                  Synthetic Process

                                  1-Aminocyclopropanecarboxylic acid is synthesized through the following routes:

                                  • Michael addition-cyclization: Acrylonitrile is reacted with diazoacetate esters in the presence of a metal catalyst to form cyclopropane intermediates, which are subsequently converted to the amino acid.

                                  • Bucherer-Bergs reaction: Cyclopropanone or suitable cyclopropyl precursors are converted via the hydantoin route to yield ACC.

                                  • Enzymatic synthesis: Specific enzymes such as ACC synthase are used for the biosynthesis of ACC in plants; chemically, the compound is also produced via ring-closing strategies.

                                  • Purification: The crude product is purified by recrystallization from water or water-ethanol mixtures.

                                  Mechanism of Action / Application Principles

                                  • Plant Physiology Research: Serves as the key substrate for ACC oxidase (ACO), the enzyme that catalyzes the final step in ethylene biosynthesis. Used extensively in studies of plant growth, development, ripening, senescence, and stress responses.

                                  • Ethylene Biosynthesis Studies: The conversion of ACC to ethylene is a critical step in the ethylene biosynthesis pathway and a target for plant growth regulators.

                                  • Conformationally Constrained Amino Acid: The cyclopropane ring locks the amino acid backbone into a fixed conformation, useful for stabilizing specific peptide secondary structures.

                                  • Peptide Synthesis: Serves as a building block for introducing cyclopropane-containing residues into peptides and peptidomimetics.

— C ompany Profile ——

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

—— Q&A ——

Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

Q4: What is your MOQ? Is there a discount?
A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.

Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.