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Home > Pharmaceutical Intermediates > Blood Glucose Regulators > Monobenzone for Sale > Monobenzone| Pharmaceutical Grade | 99.99% Purity | CAS 103-16-2
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Monobenzone| Pharmaceutical Grade | 99.99% Purity | CAS 103-16-2

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Unit Price: Get Latest Price
CAS No.:

103-16-2

Grade:

Pharmaceutical Grade

Content:

99.99%

Port:

shanghai

Brand:

Orient

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-08-13

Company Type:
Trader
Location:
China
Qualification:
Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

  • Product Description

  • Seller Information

  • Inquiry History

  • Description





    Basic Properties

    Melting Point: 119-120 °C (lit.)
    Boiling Point: 297.96 °C (rough estimate)
    Density: 1.26 g/cm³
    Refractive Index: 1.5906 (estimate)
    Storage Condition: Store below +30°C.
    Solubility: Slightly soluble in chloroform, DMSO and methanol; slightly soluble in water
    pKa: 10.29±0.15 (Predicted)
    Physical Form: Powder, crystal or block
    Color: Off-white to beige to brown
    Biological Source: Rabbit
    Merck Number: 14,6248
    BRN Number: 1958305
    InChI: 1S/C13H12O2/c14-12-6-8-13(9-7-12)15-10-11-4-2-1-3-5-11/h1-9,14H,10H2
    InChIKey: VYQNWZOUAUKGHI-UHFFFAOYSA-N
    SMILES: Oc1ccc(OCc2ccccc2)cc1
    LogP: 2.651 (est)
    CAS Registry Number: 103-16-2

    Chemical Overview

    Monobenzone, also named 4-Benzyloxyphenol, is a colorless solid compound belonging to the hydroquinone monobenzyl ether category. It is soluble in alcohol, benzene and ether, and practically insoluble in water. It is commonly used as a pharmaceutical intermediate with stable conventional chemical properties.

    Synthesis Method

    Monobenzone is synthesized with hydroquinone, sodium hydroxide and benzyl chloride as raw materials, and N,N-dimethylformamide (DMF) as solvent under microwave irradiation. The optimal synthesis conditions are confirmed via single-factor experiments.
    Optimum Process Parameters: The molar ratio of benzyl chloride, hydroquinone and sodium hydroxide is 1:1.4:1.4, with 15 mL of DMF solvent, microwave irradiation power of 320 W and irradiation time of 60 s. The product yield reaches 63.79% under this condition.
    Experimental Operation Steps: Add 2.63 g (0.028 mol) of hydroquinone and 1.12 g (0.028 mol) of sodium hydroxide into a 100 mL conical flask with 8 mL of water. After sodium hydroxide is completely dissolved and mixed evenly, add 15 mL of DMF and 2.52 g (0.02 mol) of benzyl chloride. Conduct reaction under 320 W microwave irradiation for 60 seconds, then cool the mixture to room temperature.
    Adjust the solution to alkaline with 10% sodium hydroxide solution, then perform suction filtration. Wash the filter cake (recoverable hydroquinone dibenzyl ether) with 10% sodium hydroxide solution until the filtrate is colorless. Acidify the filtrate with hydrochloric acid to precipitate monobenzone completely. After suction filtration and ice water washing, purify the product via alcohol-water recrystallization and activated carbon decolorization to obtain white solid finished product.

    Chemical Properties

    The product appears as off-white crystalline powder with stable basic chemical properties under normal temperature and pressure.

    Main Application

    It is a fine chemical product mainly used as pharmaceutical intermediate for organic synthesis and pharmaceutical manufacturing industry.

    Safety & Hazard Information

    Toxicity Grade: Moderate toxicity
    Acute Toxicity: Intraperitoneal LD50 (rat): 4500 mg/kg
    Irritation Data: Slight skin irritation on guinea pigs (5% concentration, 48-hour exposure)
    Flammability Hazard: Combustible; releases irritating smoke and gas during combustion
    Storage & Transportation Requirements: Store in ventilated, low-temperature and dry warehouse; keep away from food raw materials and separate storage is required
    Fire Extinguishing Agent: Dry powder, foam, sand, carbon dioxide, water mist


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    ECHEMI Editorial Reference
    Solid
    Solid
    Monobenzone is the monobenzyl ether of hydroquinone. It is used as a topical drug for medical depigmentation. It has a role as a melanin synthesis inhibitor, a dermatologic drug and an allergen. It derives from a hydroquinone.|Monobenzone is the monobenzyl ether of hydroquinone used medically for depigmentation. Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water. It exerts a depigmenting effect on skin of mammals by increasing the excretion of melanin from the melanocytes. It may also cause destruction of melanocytes and permanent depigmentation.|Monobenzone is a Depigmenting Agent. The mechanism of action of monobenzone is as a Melanin Synthesis Inhibitor. The physiologic effect of monobenzone is by means of Depigmenting Activity.|Monobenzone is a monobenzyl ether of hydroquinone with topical depigmentation activity. Although the exact mechanism of action of depigmentation is unknown, the metabolites of monobenzone appear to have a cytotoxic effect on melanocytes. Furthermore, the depigmentation effect might be mediated through the inhibition of tyrosinase, which is essential in the synthesis of melanin pigments, thereby causing permanent depigmentation of the skin.

    Certificates

    Basic Info
    Product Name:

    Monobenzone

    Other Name:

    Phenol,4-(phenylmethoxy)-;Phenol,p-(benzyloxy)-;4-(Phenylmethoxy)phenol;Alba-Dome;Benoquin;Hydroquinone benzyl ether;Hydroquinone monobenzyl ether;p-Hydroxyphenyl benzyl ether;Monobenzone;Monobenzyl ether hydroquinone;Monobenzyl hydroquinone;AgeRite Alba;Superlite (antioxidant);p-(Benzyloxy)phenol;4-(Benzyloxy)phenol;Benzyl p-hydroxyphenyl ether;Monobenzon;Benzoquin;Carmifal;Depigman;Dermochinona;Leucodinine;Pigmex;Superlite;Agerite;NSC 2132;NSC 33918

    CAS No.:

    103-16-2

    Molecular Formula:

    C13H12O2

    InChIKeys:

    InChIKey=VYQNWZOUAUKGHI-UHFFFAOYSA-N

    Molecular Weight:

    200.237

    Exact Mass:

    200.23

    EC Number:

    203-083-3

    UNII:

    9L2KA76MG5

    NSC Number:

    758211|33918|2132

    DSSTox ID:

    DTXSID2020717

    NCI Thesaurus Code:

    C992

    Color/Form:

    LUSTROUS LEAFLETS FROM WATER|WHITE CRYSTALLINE POWDER

    ATC Code:

    D - Dermatologicals

    HScode:

    29095090

    Characteristics
    PSA:

    29.5

    XLogP3:

    3.4

    Appearance:

    Solid

    Density:

    1.26 g/cm3

    Melting Point:

    122.5 °C

    Boiling Point:

    359.1ºC at 760mmHg

    Flash Point:

    213.4ºC

    Water Solubility:

    3.92e-02 g/L

    Storage Conditions:

    Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.

    Odor:

    ODORLESS

    Hazard Identification

    Classification of the substance or mixture

    Eye irritation, Category 2

    Skin sensitization, Category 1

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Warning

    Hazard statement(s)

    H319 Causes serious eye irritation

    H317 May cause an allergic skin reaction

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P272 Contaminated work clothing should not be allowed out of the workplace.

    Response

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P333+P317 If skin irritation or rash occurs: Get medical help.

    P321 Specific treatment (see ... on this label).

    P362+P364 Take off contaminated clothing and wash it before reuse.

    Storage

    none

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    pharmaceutical intermediates,peptides,electronic chemicals

    Location:

    Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

    Payment Terms:

    100% TT in advance

    Average lead Time:

    10

    Total Annual Revenue:

    $10 million-$25 million

    Total Employees:

    51-100

    Year of Establishment:

    2024

    A reliable supplier is like insurance.

    We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals,food additives, and other fine chemical products.
    Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

    Website: orientchem.cc
    Email: scarlett@orientchem.cc
    WhatsApp: +86 17753254221

  • Inquiry History
    53 Inquiries
    Country Product Purchase Quantity Date Posted
    Canada

    Cosmetic Raw Material 4-Benzyloxyphenol CAS 103-16-2 Monobenzone Powder

    10 KG Sep 17, 2025
    Pakistan

    monobenzone

    100 G Aug 26, 2026
    Saudi Arabia

    Monobenzone

    500 G Jun 22, 2026
    Pakistan

    monobenzone powder

    1 KG Mar 23, 2026
    United Arab Emirates

    monobenzone powder

    1 KG Feb 2, 2026
    Pakistan

    monobenzone

    1 KG Jan 19, 2026
    Pakistan

    Monobenzone

    2 KG Dec 17, 2025
    Saudi Arabia

    Monobenzone

    1 KG Nov 17, 2025
    United States

    Monobenzone

    100 G Jul 13, 2025
    Saudi Arabia

    Inquiry for Hydroquinone Monobenzyl Ether 99%

    1 KG Jul 2, 2025
    Canada

    Monobenzone powder

    1 KG Jun 25, 2025
    United States

    Monobenzone

    2 KG May 30, 2025
    Pakistan

    Monobenzone

    500 G Apr 24, 2025
    United States

    Cosmetic Raw Material 99% Purity Monobenzone Powder

    200 G Mar 18, 2025
    Saudi Arabia

    Hydroquinone Monobenzone

    1 MT Dec 27, 2024
    Brazil

    monobenzona

    500 KG Feb 18, 2024
    Thailand

    Monobenzone 99% white powder Monobenzone

    1 KG Oct 11, 2023
    Denmark

    Monobenzone

    25 KG Jul 13, 2026
    Turkey

    Monobenzone

    1 KG Jun 8, 2026
    United States

    Monobenzone

    10 MT May 30, 2026
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