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Mechanism of Action (Core: MC1R Activation)

Unlike MOTS-c, which regulates energy metabolism through AMPK activation, MT-1 primarily acts on the melanogenesis pathway to stimulate melanin production.

1. Activation of the MC1R Receptor

MT-1 binds to the melanocortin 1 receptor (MC1R) located on the surface of melanocytes in the skin, leading to:

·Activation of the cAMP signaling pathway
·Upregulation of tyrosinase expression and activity
·Enhanced synthesis of eumelanin (dark protective melanin)
·Increased melanin deposition in the skin

Results:

·Gradual darkening of skin tone
·Reduced susceptibility to sunburn
·Enhanced protection against ultraviolet (UV) radiation

2. Enhancement of Natural Photoprotection

Eumelanin provides several protective benefits, including:

·Absorption of ultraviolet radiation
·Scavenging of free radicals
·Reduction of UV-induced DNA damage

As a result, MT-1 not only promotes skin pigmentation but also improves the skin's natural tolerance to sunlight.

3. DNA Repair and Anti-Inflammatory Effects

Studies suggest that activation of MC1R may:

·Enhance cellular DNA repair mechanisms
·Reduce oxidative stress
·Suppress certain inflammatory responses

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