High Quality High Purity 99% Dihexa Peptide 5mg 10mg CAS 1401708Factory Direct Supply 99% Nootropics 6-Paradol Powder Raw Material CAS 27113-22-0
27113-22-0
Industrial Grade
99%
QINGDAO
ZIKANG
1kg/ Cardboard Drum
2026-08-14
Weight Loss Peptide,Anti Aging Peptide,Nootropic,Pharmaceutical Intermediates,Cosmetic raw material,API
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceSolid|White powder; Spicy herbal aroma
[6]-Paradol is a member of phenols, a ketone and a monomethoxybenzene.
6-Gingerol (6-gingerol) is a member of the curcumin family and is one of the main active components of ginger. It is a compound with a pungent flavor, and its chemical structure is similar to that of capsaicin, but its spiciness is only one hundredth, or even one thousandth, of that of capsaicin, and it has very little irritation.6-gingerol contains a phenolic group and an alicyclic ring in its structure, which makes it polar and hydrophobic, and thus affects its biological activity and pharmacological effects.Basic Info-
Product Name:
1-(4-hydroxy-3-methoxyphenyl)decan-5-one
Other Name:1-(4-hydroxy-3-methoxyphenyl)decan-5-one;1-(3-Methoxy-4-hydroxyphenyl)-3-decanone;1-(4-Hydroxy-3-methoxyphenyl)decan-3-one;5-Paradol;Brn 1984119;Ccris 8519;Einecs 248-228-1;Heptyl 4-hydroxy-3-methoxyphenethyl ketone
CAS No.:27113-22-0
Molecular Formula:C17H26O3
InChIKeys:CZNLTCTYLMYLHL-UHFFFAOYSA-N
Molecular Weight:278.39
Exact Mass:278.39
EC Number:248-228-1
UNII:BO24ID7E9U
DSSTox ID:DTXSID90181574
Color/Form:White to Brown
Categories:
Characteristics-
XLogP3:
4.225 (est)
Density:1.0690 g/cm3
Melting Point:31-32°C
Boiling Point:406.4±30.0 °C(Predicted)
Refractive Index:1.5232 (589.3 nm 20℃)
Water Solubility:3.802 mg/L @ 25 °C (est)|Practically insoluble or insoluble in water|Soluble (in ethanol)
Odor:spicy herbal
PKA:10.02±0.20(Predicted)
Critical Temperature & Pressure:Sealed in dry,Room Temperature
Research-
Class:
Angiotensin IV-derived oligopeptide / HGF-c-Met potentiator
Status:Research compound — Not FDA approved
Mechanism:A synthetic, orally active, blood-brain-barrier-permeable oligopeptide (Hexanoyl-Tyr-Ile-Ahx-NH₂) derived from angiotensin IV. Dihexa binds hepatocyte growth factor (HGF) with high affinity (Kd = 65 pM) and allosterically potentiates HGF activity at its receptor c-Met, promoting dendritic spinogenesis and synaptogenesis. In preclinical models it was reported to be seven orders of magnitude more potent than BDNF at promoting synapse formation. Note: the foundational 2014 paper (McCoy AT, et al. Neurobiol Learn Mem. 2014) was retracted in 2025.
EC50 (HGF Binding KD):65 pM
Activity note:Dihexa is an HGF potentiator, not a direct receptor agonist. It does not activate c-Met alone but markedly augments HGF-induced c-Met activation at low nanomolar HGF concentrations. Functional synaptogenic activity was reported at 10⁻¹°–10⁻⁻ M (original data now subject to retraction).
Source:Original report: McCoy AT, et al. Neurobiol Learn Mem. 2014;115:112-120 (retracted 2025). Benoist CC, et al. J Pharmacol Exp Ther. 2014;351(3):628-637.
Clinical Development:
References-
PubChem:UNII:Literature:
Benoist CC, et al. J Pharmacol Exp Ther. 2014 — HGF/c-Met mechanism; McCoy AT, et al. Neurobiol Learn Mem. 2014 — Synaptogenesis data (Retracted 2025); Athira Pharma: Fosgonimeton (prodrug) pipeline status
Disclaimer:Dihexa is NOT FDA-approved or EMA-approved as a medicine. It is a research compound only. The foundational 2014 paper describing its synaptogenic potency was retracted in 2025. Its phosphate prodrug fosgonimeton failed a Phase 2/3 Alzheimer’s trial (LIFT-AD, 2024). This listing is for industrial and laboratory research use only. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Hazard IdentificationClassification of the substance or mixture
Not classified.
GHS label elements, including precautionary statements
Pictogram(s) No symbol. Signal word No signal word
Hazard statement(s) none
Precautionary statement(s) Prevention none
Response none
Storage none
Disposal none
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Weight Loss Peptide,Anti Aging Peptide,Nootropic,Pharmaceutical Intermediates,Cosmetic raw material,API
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Location:
No. 23 Yanjia street, Daixi Subdistrict, Zouping City, Binzhou City, Shandong Province
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Total Annual Revenue:
$5 million-$10 million
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Total Employees:
11-50
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Year of Establishment:
2026
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
