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Guanosine 5'-monophosphate disodium salt5550-12-9

Name: Guanosine 5'-monophosphate disodium salt5550-12-9
Brand: OORENT
SKU: pr2607141571
Price: 33 USD
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CAS No.:

5550-12-9

Grade:

Industrial Grade

Content:

99%

Port:

shanghai

Brand:

OORENT

Packaging:

vial

Price valid (until):

2026-08-14

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Qingdao Orient Chemical Co.,LTD

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Description

Product Detail

Guanosine 5'-monophosphate disodium salt Basic information

Identification test Content analysis Toxicity Usage limit Chemical properties Uses Preparation

Product Name:	Guanosine 5'-monophosphate disodium salt
Synonyms:	GMP-5;Guanosine-5'-monophosphate disodium salt ,99%;GUANOSINE-5'-MONOPHOSPHATE DISODIUM SALT extrapure;Disodium 5'-inosinic acid;5μ-GMP-Na2, 5μ-Guanylic acid hydrate disodium salt;Guanosine 5μ-monophosphate hydrate disodium salt;5’-gmpdisodiumsalt;SODIUM GUANYLATE
CAS:	5550-12-9
MF:	C10H15N5NaO8P
MW:	387.22
EINECS:	226-914-1
Product Categories:	Nucleic acids;Pharmaceutical Intermediates;Biochemistry;Nucleosides, Nucleotides & Related Reagents;Nucleotides and their analogs;Pharmaceutical;Nucleotide
Mol File:	5550-12-9.mol

Guanosine 5'-monophosphate disodium salt Chemical Properties

Melting point	300°C
FEMA	3668 \| DISODIUM 5-GUANYLATE
storage temp.	2-8°C
solubility	H2O: soluble50mg/mL, clear, colorless to faintly yellow
form	Crystalline Powder
color	White
Odor	odorless
biological source	yeast
Water Solubility	>50 g/L
BRN	3586801
Cosmetics Ingredients Functions	SKIN CONDITIONING - EMOLLIENT HUMECTANT SKIN CONDITIONING
InChIKey	VNIAITIBSZCQNA-NGPBCCOENA-N
SMILES	O=C1NC(N)=NC2N([C@H]3[C@@H]([C@H](O)[C@@H](COP(O)(O)=O)O3)O)C=NC1=2.[NaH] \|&1:8,9,10,12,r\|
LogP	-0.42
CAS DataBase Reference	5550-12-9(CAS DataBase Reference)
EPA Substance Registry System	5'-Guanylic acid, disodium salt (5550-12-9)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	22-24/25-36/37/39-27-26
WGK Germany	2
RTECS	MF9290000
TSCA	TSCA listed
HS Code	29349990
Storage Class	11 - Combustible Solids
Toxicity	LD50 oral in rat: > 17300mg/kg

MSDS Information

Provider	Language
SigmaAldrich	English

Guanosine 5'-monophosphate disodium salt Usage And Synthesis

Identification test	UV absorbance: A 1/50000 sample solution was prepared with 0.01 mol/L hydrochloric acid solution, which had a maximum absorbance at a wavelength of 256 nm ± 2 nm. A250/A260 ratio is at the range of 0.95 to 1.03, and A280/A260 ratio is at the range of 0.63 to 0.71. Ribose test exhibits positive result. Take 3 mL of 0.03% sample solution, add 0.2 mL of the ethanol solution of 10% dihydroxy toluene, and 3 mL 0.1% ammonium ferric sulfate hydrochloric acid (TS-100), heat in water bath for 10 min, the color of the solution should be green. Organic phosphate test is positive. Take 5 mL of 1% sample solution plus 2 mL of magnesium oxide mixture solution (TS-133), there should be no precipitation occurred. Further add 7 mL of nitric acid and boil for 10min, neutralize with sodium hydroxide solution (TS-224) and should exhibit phosphate reaction (IT-26). The sodium salt test was positive (IT-28). Solubility: it is soluble in water, slightly soluble in ethanol but almost insoluble in acetone and ether (OT-42).
Content analysis	Accurately weigh 500 mg of sample and dissolve with 0.01 mol/L hydrochloric acid, and add the volume up to 1000 ml. Take 10 mL of this solution, and then add 0.01mol/L hydrochloric acid to a final volume of 250 ml and mix. Use 0.01mol/L hydrochloric acid as a control, place it in 1 cm cuvette and measure the absorbance A under the wavelength of 260nm and then calculated as follows: Amount (%) = A/289.8 × 250,000/Sample amount (mg) × 100/(100-Moisture (%)) × 100
Toxicity	ADI is not subject to special provision (FAO/WHO, 2001). LD50:10 mg/kg (rat, oral). After chronic test feeding of 0.1% to 1% feed for 6 months, weight and tissue get no abnormal changes. It can be safely used in food products (FDA, §172.530, 2000). EEC-HACSG provides that it should not be used for infant food.
Usage limit	GB 2760-96: all kinds of food, take GMP limit. FAO WHO: luncheon meat, ham, bacon, etc., 500 mg kg (in guanosine), broth and soup, GMP. Standard for Maximum Allowable amount and maximal allowable residue of Food Additives Name of additive Food allowed to use it as additive Function of additive Maximal allowable amount（g/kg） Maximal allowable amount（g/kg） 5'-guanylate disodium Food Food purpose flavor The perfume ingredients used in formulating fragrances shall not exceed the maximal allowable amount documented in GB 2760 5'-guanylate disodium Food Flavoring agent Apply appropriate amount based on the demand of production except in cases where there is specific rule
Chemical properties	It appears as colorless to white crystalline or crystalline powder, usually containing 7 molecules of crystal water, being odorless, having unique flavor similar to mushrooms. Melting point is not obvious. It undergoes browning under 240 ℃ and decomposition under 250 ℃. It is stable against acid, alkali, salt and heat. It has strong moisture absorption property and is easily soluble in water (25 ℃, 25%). The pH value of its 5% aqueous solution is 7.0 to 8.5, being slightly soluble in ethanol, acetone and ether. Mouse: oral LD50: 10g/kg, ADI does not require special rule(FAO/WHO, 1994).
Uses	Guanylate sodium is allowed flavoring agent allowed at home and abroad, often used together with MSG and sodium inosinate. When mixed for usage, it has multiplication effect on the taste. It can be used for all types of food and should be subject to appropriate use according to production needs. It is mainly used as condiments, being a new generation food by freshener. It is a kind of flavor agent with mushrooms flavor. It is often used in conjunction with sodium glutamate (adding amount is 1%~5%), there is a very significant increase in freshener effect.
Preparation	The production methods of guanylic acid mainly include enzymatic hydrolysis and fermentation method. In the fermentation method, there are two-step method and combination method with biosynthesis and chemical synthesis, two kinds which are of industrial significance. (1) Ribonucleic acid (RNA) hydrolysis method. See the production method of 5'-inosinic acid disodium. (2) Two-step method. Take glucose as the carbon source and ferment with the Bacillus subtilis mutant to obtain the guanosine. The production level was 10.5 g/L. Then guanosine, in pyridine solution, is acidified with phosphorus oxychloride phosphate to obtain guanylate. (3) Biosynthesis and chemical synthesis. At pH=7, apply Bacillus megaterium (No. 336) for fermentation of glucose (8%) for 90 h at pH = 7, producing 15 g/L 5-amino-4-carboxamide nucleoside (AICAr); then extract by ion exchange, followed by concentration and drying to be dissolved in methanol containing NaOH. Add carbon disulfide for co-heating so that it is converted into 2-thioglycoside; It is finally oxidized with hydrogen peroxide; add excess ammonia and heat to obtain guanosine which is further converted to guanylate through phosphorylation.
Properties and Applications	Disodium guanylate contains approximately seven molecules of water of crystallization. It has a characteristic taste. Disodium guanylate (GMP) is often used in combination with disodium inosinate (IMP) and monosodium glutamate (MSG). These substances are some of the taste principle components in both animal and vegetable foods, and they contribute to a fundamental taste sensation called "savory." The taste intensity differs with the concentration. Although taste quality of IMP or GMP in the presence of MSG is almost similar, GMP provides smoother “fullness” and “thickness” than IMP. The synergistic effect between nucleotides and MSG in cooking has long been empirically established.
Chemical Properties	White crystalline powder
Occurrence	Reported found in mushroom (shiitake, enokidake, matsutake, syoro, hatsutake), pork, chicken and whale
Uses	These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Uses	Flavor potentiator in foods.Sodium Guanylate is a salt replacement flavor enhancer. Food additive.
Uses	Guanosine 5'-monophosphate disodium salt is a flavor enhancer which is a crystalline powder, colorless or white, and has characteristic taste. It is soluble in water, sparingly soluble in alcohol, and practically insoluble in ether. It is obtained by chemical synthesis. It is also termed sodium 5-guanylate and disodium guanosine-5-monophosphate.
Definition	ChEBI: An organic sodium salt that is the disodium salt of GMP.
Preparation	This flavor enhancer is derived from fungal sources.
Taste threshold values	0.0125 g/dL (in water)
General Description	Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Disodium Guanylate is a flavor enhancer, obtained via chemical synthesis. It is used in combination with monosodium glutamate and disodium inosinate and helps in contributing to a fundamental taste sensation called savory in both animal and vegetable foods.
Biochem/physiol Actions	Guanosine 5'-monophosphate disodium salt (GMP) is a ribonucleoside monophospate which upon phosphorylation to GTP becomes incorporated into ribonucleic acids (RNAs) by various RNA polymerase(s). Guanosine-5′-monophosphate (GMP) can be used to study modulation of glutamatergic neurotransmission.

Guanosine 5'-monophosphate disodium salt Preparation Products And Raw materials

Raw materials	Carbon disulfide-->D(+)-Glucose-->Ribonucleic acid-->5'-Guanylic acid-->Guanosine
Preparation Products	Disodium 5'-Inosinate-->Inosine-->CALCIUM5'-RIBONUCLEOTIDES-->Calcium 5'-ribonucleotide

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Basic Info

Product Name:

Guanosine 5'-monophosphate disodium salt

Other Name:

GMP-5;Guanosine-5'-monophosphate disodium salt ,99%;GUANOSINE-5'-MONOPHOSPHATE DISODIUM SALT extrapure;Disodium 5'-inosinic acid;5μ-GMP-Na2, 5μ-Guanylic acid hydrate disodium salt;Guanosine 5μ-monophosphate hydrate disodium salt;5’-gmpdisodiumsalt;DISODIUM GUANOSINE-5'-MONOPHOSPHATE

CAS No.:

5550-12-9

Molecular Formula:

C10H15N5NaO8P

InChIKeys:

VNIAITIBSZCQNA-NGPBCCOENA-N

Molecular Weight:

387.22

Exact Mass:

407.021881

BRN:

3586801

EC Number:

226-914-1

TSCA:

TSCA listed

DSSTox ID:

DTXSID9044245

Color/Form:

White

HScode:

29349990

Categories:

Food Flavorings

Characteristics

PSA:

221.51000

XLogP3:

-1.11210

Appearance:

White Crystalline Powder

Melting Point:

300°C

Boiling Point:

890.2ºC at 760 mmHg

Flash Point:

492.2ºC

Water Solubility:

>50 g/L

Storage Conditions:

2-8°C

Toxicity:

ADI is not subject to special provision (FAO/WHO, 2001).LD50:10 mg/kg (rat, oral). After chronic test feeding of 0.1% to 1% feed for 6 months, weight and tissue get no abnormal changes.It can be safely used in food products (FDA, §172.530, 2000).EEC-HACSG provides that it should not be used for infant food.

Odor:

odorless

PH:

Between 7,0 and 8,5 (5 % solution)

Collision Cross Section:

171.7 Å² [M-H]-

Critical Temperature & Pressure:

2-8°C

See More Guanosine 5'-monophosphate disodium salt Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Guanosine 5'-monophosphate disodium salt Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

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Country	Product	Purchase Quantity	Date Posted
United States	Guanosine 5'-monophosphate disodium salt	2 KG	Jul 14, 2026

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Guanosine 5'-monophosphate disodium salt5550-12-9

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