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Phosphate -1310746-10-1

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$890-899/MT FOB

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CAS No.:

1310746-10-1

Grade:

Pharmaceutical Grade

Content:

99%

Port:

CHINA

Packaging:

Price valid (until):

2026-08-14

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38 ASHFORD ROAD LLC

Company Type:

Trader

Location:

United States

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Main Products:

peptides

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Items	Specifications
NVP BGJ398 phosphate
Description: IC50 Value: 0.9 nM (FGFR1); 1.4 nM (FGFR2); 1 nM (FGFR2) [1] NVP-BGJ398 is a novel selective, pan-specific FGFR inhibitor currently in Phase I clinical trials for cancer therapy. in vitro: NVP-BGJ398 is a novel and selective fibroblast growth factor receptor (FGFR) inhibitor. NVP-BGJ398 inhibit FGFR1, FGFR2, FGFR3 with IC50 of 0.9 nM, 1.4 nM and 1 nM. NVP-BGJ398 inhibited FGFR1, FGFR2, and FGFR3 with single digit nmol/L IC50 in biochemical and cellular autophosphorylation assays and FGFR4 with 38- to 60-fold lower potency. NVP-BGJ398 significantly inhibits proliferation of cancer cell lines bearing FGF/FGFR genetic alterations across various cancer types.Among the 35 cell lines selected from the high-throughput assays, 28 were confirmed as sensitive to NVP-BGJ398 with IC50s ranging from 0.001 to 500 nM. Cancer cell lines harboring FGF19 copy number gain at the 11q13 amplicon are sensitive to NVP-BGJ398 only when concomitant expression of beta-klotho occurs [1]. Cell lines with activating FGFR2 mutations (S252W, N550K) were more sensitive to dovitinib or NVP-BGJ398 when compared with their FGFR2 wild-type counterparts (P = 0.073 and P = 0.021, respectively). Both agents inhibited FGFR2 signaling, induced cell-cycle arrest, and significantly increased apoptosis in FGFR2-mutant lines. In vitro, dovitinib and NVP-BGJ398 were both potent at inhibiting cell growth of FGFR2-mutant endometrial cancer cells, but the activity of dovitinib was less restricted to FGFR2-mutant lines when compared with NVP-BGJ398 [2]. in vivo: In tumor tissues from primary tumor model GAM033 treated with 15 mg/kg NVP-BGJ398, NVP-BGJ398 shows inhibition to FGFR and ERK1/2 [1].NVP-BGJ398 significantly inhibited the growth of FGFR2-mutated endometrial cancer xenograft models [2]. Toxicity: N/A Clinical trial: Phase 1

Basic Info

Product Name:

Infigratinib phosphate

CAS No.:

1310746-10-1

Categories:

Bulk Drug Intermediates

Seller Information

Business Type:
Trader

Main Products:
peptides

Location:
126 AUTUMN ROAD ,LAKEWOOD NEW JERSEY

Payment Terms:
TT against copy of documents,100% TT in advance

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2023

Certifications:
certifacate for peptieds

Inquiry History

6 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	NVP BGJ398 Phosphate	1 KG	Jul 15, 2026
United States	NVP BGJ398 phosphate	3 G	Jul 15, 2026
United States	Infigratinib	9 G	Jul 18, 2026
United States	Infigratinib phosphate powder	6 G	Jun 9, 2026
United States	NVP-BGJ398 phosphate	18 G	Jul 14, 2026
United States	NVP BGJ398 phosphate	4 G	Mar 11, 2026

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Phosphate -1310746-10-1

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